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Thiophosphoric triamide

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Identification
Molecular formula
C6H15N3PS
CAS number
597-68-2
IUPAC name
tris(aziridin-1-yl)-thioxo-lambda5-phosphane
State
State

Solid

Melting point (Celsius)
78.00
Melting point (Kelvin)
351.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
204.23g/mol
Molar mass
204.2250g/mol
Density
1.5900g/cm3
Appearence

The compound typically appears as a colorless crystalline solid or powder. It may look slightly off-white if impurities are present.

Comment on solubility

Solubility of Tris(aziridin-1-yl)-thioxo-lambda5-phosphane (C6H15N3PS)

When discussing the solubility of tris(aziridin-1-yl)-thioxo-lambda5-phosphane, it is crucial to consider the compound's unique structure and functional groups. As a phosphorus-containing compound, it may display distinct solubility characteristics depending on several factors:

  • Polarity: The presence of nitrogen atoms in the aziridine rings and the thioxo (S) functional group enhances its polar characteristics, which can influence solubility in polar solvents.
  • Solvent Type: Compounds of this nature generally show better solubility in polar solvents such as water or alcohols as opposed to non-polar solvents.
  • Concentration Effects: The solubility may also be concentration-dependent, potentially leading to varied solubility profiles at different concentrations.

In general, phosphorus-based compounds can exhibit a range of solubility due to their diverse chemical properties. As it stands, the solubility of tris(aziridin-1-yl)-thioxo-lambda5-phosphane may be favorable in specific formulations but may require thorough testing to establish exact solubility data. As a general rule, always ensure to evaluate solubility within the specific context of use.

Interesting facts

Interesting Facts about Tris(aziridin-1-yl)-thioxo-lambda5-phosphane

Tris(aziridin-1-yl)-thioxo-lambda5-phosphane is a fascinating compound with various intriguing properties and applications. Here are some noteworthy aspects:

  • Unique Structure: This compound features a phosphorus(III) center attached to three aziridine rings. Aziridines are three-membered cyclic amines, and their incorporation into the structure imparts unique reactive properties.
  • Thioxo Group: The presence of a thioxo group (S=O) in the compound introduces interesting reactivity, making it a useful intermediate in synthetic organic chemistry.
  • Potential Applications: Research indicates that derivatives of aziridine and phosphane compounds can have applications in medicinal chemistry and materials science. They are often investigated for their potential as antibacterial agents and in polymerization processes.
  • Reaction Mechanisms: The reactivity of tris(aziridin-1-yl)-thioxo-lambda5-phosphane can be explored through various reaction mechanisms, providing valuable insights into its chemistry. For example, it can participate in nucleophilic substitution reactions, which are essential in the synthesis of complex organic molecules.
  • Research Frontier: This compound belongs to a class of organophosphorus compounds that are still being studied, with ongoing research focused on understanding their full potential and developing new derivatives with enhanced properties.

In summary, tris(aziridin-1-yl)-thioxo-lambda5-phosphane is more than just a chemical formula; it opens the door to ongoing scientific investigations and innovative applications in various fields of chemistry. Its unique structure and properties make it a compound of interest for both researchers and industry practitioners alike.

Synonyms
thiotepa
52-24-4
THIO-TEPA
Triethylenethiophosphoramide
Thioplex
Thiophosphamide
Tespamin
Thiofozil
Tiofosfamid
Girostan
Tiofosyl
Tri(aziridin-1-yl)phosphine sulfide
Oncotepa
Tespamine
Tiofozil
Stepa
TESPA
Oncotiotepa
Thiotef
Tifosyl
Oncothio-tepa
Tio-tef
Thio-Tep
tepadina
1,1',1''-phosphorothioyltriaziridine
Thio-tepa S
Tris(1-aziridinyl)phosphine sulfide
TIO TEF
Ledertepa
Tiotepa
Thiophosphamidum
NSC-6396
Thiotriethylenephosphoramide
Triethylene thiophosphoramide
Tepylute
Thiotepum
N,N',N''-Triethylenethiophosphoramide
Triaziridinylphosphine sulfide
Triethylenethiophosphorotriamide
Tris(ethylenimino)thiophosphate
Thiotepum [INN-Latin]
Tiotepa [INN-Spanish]
CBC 806495
Phosphorothioic acid triethylenetriamide
Tris(aziridinyl)phosphine sulfide
Phosphine sulfide, tris(1-aziridinyl)-
Tri(ethyleneimino)thiophosphoramide
Aziridine, 1,1',1''-phosphinothioylidynetris-
NCI-C01649
NSC 6396
CCRIS 586
SK 6882
HSDB 3258
NSC6396
Tri-1-aziridinylphosphine sulfide
AI3-24916
EINECS 200-135-7
Tris(1-aziridinyl)phosphine sulphide
N,N',N''-Triethylenethiophosphamide
Tepadina (TN)
Thioplex (TN)
Rethio (TN)
BRN 0145978
905Z5W3GKH
MLS001333083
N,N',N''-Triethylenethiophosphortriamide
DTXSID0021339
WR-45312
Thiotepa [USP:INN:BAN:JAN]
1,1',1''-Phosphinothioylidynetrisaziridine
Tri(1-aziridinyl)phosphine sulfide
N,N',N''-Triethylenephosphorothioic triamide
THIOTEPA [HSDB]
THIOTEPA [IARC]
THIOTEPA [INN]
THIOTEPA [JAN]
THIOTEPA [MI]
THIOTEPA [VANDF]
N,N',N''-Tri-1,2-ethanediylthiophosphoramide
MFCD00145452
THIOTEPA [MART.]
THIOTEPA [USP-RS]
THIOTEPA [WHO-DD]
Thiophosphoramide, N,N',N''-tri-1,2-ethanediyl-
Thiotepa (JAN/USP/INN)
THIOTEPA [EMA EPAR]
AZIRIDINE,1,1',1''-PHOSPHINOTHIOYLIDYNETRIS-
N,N',N''-Tri-1,2-ethanediylphosphorothioic triamide
MLS003389372
THIOTEPA [ORANGE BOOK]
CHEBI:9570
DTXCID201339
Phosphorothioic triamide, N,N',N''-tri-1,2-ethanediyl-
AI 3-24916
THIOTEPA [USP MONOGRAPH]
Phosphorothioic triamide, N,N',N''-triethylene-
4-20-00-00052 (Beilstein Handbook Reference)
NCGC00095042-04
NCGC00095042-06
PHOSPHOROTHIOIC TRI(ETHYLENEAMIDE)
THIOTEPA (IARC)
Thiotepum (INN-Latin)
Tiotepa (INN-Spanish)
tris(aziridin-1-yl)-lambda5-phosphanethione
tris(aziridin-1-yl)-sulfanylidenephosphorane
tris(aziridin-1-yl)-$l^{5}-phosphanethione
THIOTEPA (MART.)
THIOTEPA (USP-RS)
1,1',1''-PHOSPHINOTHIOYLIDYNETRIS(AZIRIDINE)
THIOTEPA (USP MONOGRAPH)
Thiotepa (USP:INN:BAN:JAN)
Thio Tepa
CAS-52-24-4
SMR000058542
tris(aziridin-1-yl)-$l^(5)-phosphanethione
SR-05000001855
UNII-905Z5W3GKH
Oncothiotepa
Thiofosfamide
Rethio
thiotepa?
Thiotepa S
Thiotepa (Thioplex)
Spectrum_001689
WR 45312
Thio-TEPA (Standard)
Thiophosphoramide, N,N',N''-triethylene-
Spectrum2_001557
Spectrum3_001594
Spectrum4_000208
Spectrum5_001641
tris(aziridin-1-yl)-thioxo-$l^{5}-phosphane
CHEMBL671
Thioplex (TN) (Immunex)
Tris(aziridinyl)-phosphine sulfide (thio-tepa)
SCHEMBL4760
Thio-TEPA, 98%, solid
BSPBio_003188
KBioGR_000815
KBioSS_002169
MLS001333084
MLS002207150
MLS006009972
BIDD:GT0127
DivK1c_000817
SPECTRUM1503324
SPBio_001434
Tri1aziridinylphosphine sulfide
tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane
GTPL7622
HMS502I19
KBio1_000817
KBio2_002169
KBio2_004737
KBio2_007305
KBio3_002688
N,N''-Triethylenethiophosphamide
L01AC01
N,N',N"Triethylenethiophosphamide
NINDS_000817
HMS1922A14
HMS2093E05
HMS2232P17
HMS3372D10
HMS3753E09
N,N''-Triethylenethiophosphoramide
Pharmakon1600-01503324
Tris(1aziridinyl)phosphine sulfide
Tris(1aziridinyl)phosphine sulphide
ALBB-034802
BCP04110
N,N',N"Triethylenethiophosphoramide
Tox21_111399
Tox21_400065
BDBM50418086
CCG-39776
HY-17574R
NSC758455
Phosphine sulfide, tris(1aziridinyl)
s1775
Tris(aziridin-1-yl)phosphine sulfide
AKOS005267118
Thiophosphoramide, N,N',N"triethylene
CS-3119
DB04572
FT03758
NSC-758455
WR45312
1,1''-Phosphinothioylidynetrisaziridine
IDI1_000817
N,N', N''-Triethylenethiophosphoramide
N,N',N''Triethylenethiophosphortriamide
Thiophosphoramide,N',N'' -triethylene-
N,N',N'''-Triethylenethiophosphhoramide
NCGC00095042-01
NCGC00095042-02
NCGC00095042-03
NCGC00095042-05
NCGC00095042-07
NCGC00095042-08
NCGC00095042-09
AS-16885
HY-17574
N,N''-Triethylenephosphorothioic triamide
NCI60_013117
1,1',1''-Phosphinothioyldynetrisaziridine
1,1',1''Phosphinothioylidynetrisaziridine
Aziridine,1,1',1'phosphinothioylidynetris
N,N',N''Tri1,2ethanediylthiophosphoramide
SBI-0051814.P002
1,1',1\"-phosphinothioylidynetrisaziridine
1ST164080
Aziridine,1',1''-phosphinothioylidynetris-
N,N''-Tri-1,2-ethanediylthiophosphoramide
N,N',N''Triethylenephosphorothioic triamide
Phosphorothioic triamide,N',N''-triethylene
Thiophosphoramide, N,N',N'' -triethylene-
NS00010011
Phosphorothioic triamide, N,N',N"triethylene
WLN: T3NTJ APS&- AT3NTJ&- AT3NTJ
Thiophosphoramide, N,N',N''tri1,2ethanediyl
1-[Di(1-aziridinyl)phosphorothioyl]aziridine #
C07641
D00583
EN300-120883
Phosphorothioic triamide, N,N',N''-triethylene
Thiophosphoramide,N',N''-tri-1,2-ethanediyl-
AB00052346-06
AB00052346_07
N,N''-Tri-1,2-ethanediylphosphorothioic triamide
N,N',N''Tri1,2ethanediylphosphorothioic triamide
Q416507
Phosphorothioic triamide, N,N',N''tri1,2ethanediyl
SR-05000001855-1
SR-05000001855-5
BRD-K09631521-001-05-7
BRD-K09631521-001-09-9
BRD-K09631521-001-11-5
Phosphorothioic triamide,N',N''-tri-1,2-ethanediyl-
Z1201619320
Thiotepa, United States Pharmacopeia (USP) Reference Standard
Tris(aziridinyl)phosphine sulfide; Triethylenethiophosphoramide
1631739-26-8
200-135-7