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Trimeprazine

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Identification
Molecular formula
C18H22N2S
CAS number
84-96-8
IUPAC name
trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium
State
State

At room temperature, Trimeprazine is typically in a solid state. It is commonly used in its tartrate salt form in pharmaceuticals, which is more effective for solubility and administration.

Melting point (Celsius)
188.00
Melting point (Kelvin)
461.15
Boiling point (Celsius)
410.30
Boiling point (Kelvin)
683.50
General information
Molecular weight
372.54g/mol
Molar mass
372.5410g/mol
Density
1.2020g/cm3
Appearence

Trimeprazine typically appears as a white to off-white crystalline powder. It is often presented in its salt form as a tartrate for pharmaceutical applications, which facilitates better solubility.

Comment on solubility

Solubility of Trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium

The solubility of trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium (C18H22N2S) is influenced by several factors due to its complex molecular structure. Here are key points to consider:

  • Polar vs. Non-polar: This compound features a phenothiazine ring, which typically displays limited solubility in polar solvents but can show better solubility in non-polar organic solvents.
  • Ionic Nature: Being a quaternary ammonium compound, it is likely to exhibit increased solubility in polar solvents due to its charged nature, especially in aqueous solutions.
  • Influencing Factors: The solubility may vary with temperature and pH, which can alter the ionization state of the ammonium group, thereby affecting solubility.
  • Practical Applications: Understanding the solubility is crucial for applications in pharmaceuticals, where effective dissolution can impact bioavailability.

In conclusion, while trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium is likely soluble in polar solvents, particularly water, its non-polar characteristics suggest it may also dissolve well in organic solvents. As with many compounds, conducting solubility tests under varying conditions is essential to gain comprehensive insights.

Interesting facts

Interesting Facts about Trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium

Trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium is a fascinating compound with unique properties and applications. Here are some intriguing aspects of this compound:

  • Diverse Applications: This compound is significant in the field of pharmaceuticals, particularly in the development of psychoactive medications. Compounds similar to this one have been studied for their effects on neurotransmitter systems in the brain.
  • Phenothiazine Derivative: Its structure includes a phenothiazine moiety, a component found in various antipsychotic and antihistaminic drugs. The phenothiazine nucleus is known for its ability to interact with dopamine receptors.
  • Charge Properties: The trimethylammonium group renders this compound a quaternary ammonium salt, imparting unique solubility and reactivity characteristics. The positive charge can enhance the interaction with biological targets, making it a candidate for drug development.
  • Synthetic Relevance: The synthesis of this compound can involve various methods, including multistep reactions that can lead to modifications in its therapeutic actions. This aspect is crucial for chemists looking to optimize drug efficacy.
  • Research Potential: Ongoing studies explore the potential of trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium in the domain of neuropharmacology. Researchers are investigating the compound's mechanisms, side effects, and overall therapeutic window.

In summary, trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium is more than just a chemical entity; it represents a cornerstone in the ongoing pursuit of understanding complex biological systems and advancing medication development.

Synonyms
Thiazinamium
thiazinam
2338-21-8
methylpromethazine
EINECS 219-051-7
trimethyl(1-phenothiazin-10-ylpropan-2-yl)azanium
666W2P28N2
THIAZINAMIUM [WHO-DD]
Trimethyl(1-methyl-2-phenothiazin-10-ylethyl)-ammonium
DTXSID001021633
10H-Phenothiazine-10-ethanaminium, N,N,N,alpha-tetramethyl-,
trimethyl(1-(10H-phenothiazin-10-yl)propan-2-yl)azanium
trimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]azanium
UNII-666W2P28N2
SCHEMBL4425937
Trimethyl(1-methyl-2-phenothiazin-10-ylethyl)ammonium
CHEMBL2111135
CDXCCYNINPIWGE-UHFFFAOYSA-N
CHEBI:135268
DTXCID301506642
DB13420
DB-257202
NS00008949
Q7783885
Trimethyl-(1-phenothiazin-10-ylpropan-2-yl)azanium
trimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium
N,N,N-Trimethyl-N-[1-methyl-2-(10-phenothiazinyl)ethyl]-ammonium
10H-PHENOTHIAZINE-10-ETHANAMINIUM, N,N,N,.ALPHA.-TETRAMETHYL-