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Thieno[2,3-b]pyridine-2-carboxamidine

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Identification
Molecular formula
C8H7N3S
CAS number
913523-04-7
IUPAC name
thieno[2,3-b]pyridine-2-carboxamidine
State
State

At room temperature, thieno[2,3-b]pyridine-2-carboxamidine is typically found in a solid state, often in the form of a powder.

Melting point (Celsius)
237.00
Melting point (Kelvin)
510.15
Boiling point (Celsius)
410.25
Boiling point (Kelvin)
683.40
General information
Molecular weight
161.23g/mol
Molar mass
161.2010g/mol
Density
1.2800g/cm3
Appearence

Thieno[2,3-b]pyridine-2-carboxamidine typically appears as an off-white to yellowish powder. It may be crystalline in nature depending on its purity and the conditions of crystallization.

Comment on solubility

Solubility of Thieno[2,3-b]pyridine-2-carboxamidine

Thieno[2,3-b]pyridine-2-carboxamidine, with the chemical formula C8H7N3S, exhibits interesting solubility characteristics that influence its application in various fields. Understanding the solubility of this compound can be important for its synthesis, formulation, and usage in biological systems. Here are some key points regarding its solubility:

  • Solvent Compatibility: This compound is expected to be soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and methanol, but may show limited solubility in non-polar solvents.
  • Temperature Dependence: The solubility of thieno[2,3-b]pyridine-2-carboxamidine increases with temperature, making it easier to dissolve in higher temperatures, which can be critical for reactions or pharmaceutical formulations.
  • pH Influence: The solubility can vary significantly with the pH of the solution due to the presence of the amidine functional group; under acidic conditions, it may become more soluble.
  • Crystallinity: The crystalline form of this compound can affect its solubility; amorphous forms generally exhibit higher solubility than crystalline forms.
  • Practical Application: Knowledge of its solubility profile is essential for its use in drug formulations, as it directly affects the bioavailability and pharmacokinetics of the compound.

In summary, while specific solubility data may vary, the key aspects highlighted above are significant in understanding how thieno[2,3-b]pyridine-2-carboxamidine behaves in different environments. Always consider the solvent and environmental factors for optimal utilization of this compound.

Interesting facts

Interesting Facts about Thieno[2,3-b]pyridine-2-carboxamidine

Thieno[2,3-b]pyridine-2-carboxamidine is a fascinating organic compound with intriguing structural characteristics and potential applications in various fields. Here are some notable facts:

  • Structural Uniqueness: This compound features a fused bicyclic structure that includes both a thiophene and a pyridine ring. This fusion is responsible for many of its unique chemical properties and behaviors.
  • Bioactive Properties: Thieno[2,3-b]pyridine derivatives have garnered attention in medicinal chemistry due to their potential as pharmaceutical agents. For instance, they have been studied for their activity against cancer cells and as anti-inflammatory agents.
  • Versatility: The carboxamidine functional group in the compound provides a site for further chemical modifications, allowing chemists to design new derivatives that may enhance desired biological activities or improve specificity.
  • Importance in Research: Researchers are actively investigating the properties of thieno[2,3-b]pyridine-2-carboxamidine and its derivatives to explore potential uses in agrochemicals and materials science, showcasing its versatility beyond medicinal applications.
  • Synthetic Routes: The synthesis of this compound involves several steps, often employing reactions that allow chemists to manipulate various functional groups, thus expanding the knowledge on thieno-heterocycles.

As inquisitive chemists and students delve into the world of thieno[2,3-b]pyridine-2-carboxamidine, they encounter a rich tapestry of opportunities for discovery and innovation. The ongoing research into this compound not only enhances our understanding of thieno-heterocycles but also paves the way for the development of novel therapeutic agents.

In the words of one prominent chemist, "Each compound is like a key; the more we learn about it, the more doors we can unlock in the realms of science."

Synonyms
1c5t
1c5y
SCHEMBL4317987
NS00068897