Interesting facts
Interesting Facts about Thiazolidine-2,4-dione
Thiazolidine-2,4-dione, often referred to as a member of the thiazolidine family, is a fascinating compound that has garnered attention in both organic chemistry and medicinal fields. Here are some intriguing aspects:
- Medical Relevance: Thiazolidine-2,4-dione derivatives have been explored for their potential in treating various diseases, particularly type 2 diabetes. They act as insulin sensitizers, helping to improve blood sugar control.
- Structural Features: The structure of thiazolidine-2,4-dione includes a thiazolidine ring, which consists of a five-membered ring containing both nitrogen and sulfur. This unique configuration contributes to its reactivity and biological activity.
- Biochemistry: The compound is known to influence cellular signaling pathways, particularly those involving peroxisome proliferator-activated receptors (PPARs). These receptors play a crucial role in regulating metabolism, making thiazolidine-2,4-dione relevant in studies of obesity and metabolic syndrome.
- Synthesis: The synthesis of thiazolidine-2,4-dione typically involves the cyclization of specific amino acids and thioketones. Researchers continuously seek more efficient synthetic routes to explore its derivatives and analogs.
- Research Applications: Scientists are investigating the broader implications of thiazolidine-2,4-dione in areas like cancer research, due to its potential effects on cell proliferation and apoptosis (programmed cell death).
- Environmental Impact: Some studies have raised concerns about the environmental persistence of thiazolidine compounds, emphasizing the importance of understanding their long-term effects when they enter ecosystems.
Overall, thiazolidine-2,4-dione stands out as a compound with significant implications in health and disease. Its intricate structure and versatile applications make it a compelling subject for ongoing research in the fields of chemistry and medicine.
Synonyms
2,4-THIAZOLIDINEDIONE
2295-31-0
1,3-Thiazolidine-2,4-dione
Thiazolidinedione
thiazolidine-2,4-dione
2,4-Dioxothiazolidine
2,4(3H,5H)-Thiazoledione
MFCD00005478
USAF EK-5496
CHEBI:50992
Thiazolidinedione-2,4
thiazolidin-2,4-dione
AA68LXK93C
NSC6745
NSC-6745
Thiazolidindione
2,4-thiazolidindione
2,4-thiazolidine dione
NSC 6745
EINECS 218-941-2
UNII-AA68LXK93C
BRN 0110700
1,3-Thiazolane-2,4-dione
AI3-61185
thiazolidine-dione
2,4thiazolidinedione
thiazole-2,4-dione
2,4 thiazolidinedione
2,5H)-Thiazoledione
thiazolidine-2,4 dione
WLN: T5SVMV EHJ
SCHEMBL5043
1,3-thiazole-2,4-dione
4-27-00-03144 (Beilstein Handbook Reference)
CHEMBL85398
SCHEMBL8158011
DTXSID5040623
1,3-Thiazolidine-2,4-dione #
BCP26341
AC7504
BDBM50502228
STK159523
2,4-DIOXO-1,3-THIAZOLIDINE
AKOS000119892
AKOS025397012
AC-3453
CS-W019917
DB11898
FT16406
2-THIAZOLIN-4-ONE, 2-HYDROXY-
AS-15441
HY-59272
SY001546
GW3478456
NS00027309
T1990
2,4-Thiazolidinedione, technical grade, 90%
EN300-18067
SR-01000945204
1,3-Thiazolidine-2,4-dione;2,4-Thiazolidinedione
Q1393556
SR-01000945204-1
BRD-K70526448-001-02-0
Z57131032
F1028-0003
9UT
OD3
Solubility of Thiazolidine-2,4-dione
Thiazolidine-2,4-dione (C3H5NO2S), commonly known as a derivative of thiazolidine, exhibits interesting solubility characteristics that are crucial for its applications in various fields.
Key Points on Solubility:
As solubility is a key factor in determining how a compound behaves in biological and chemical processes, understanding thiazolidine-2,4-dione's solubility not only aids in practical applications but also sheds light on its reactivity and interaction with other chemicals.
In summary, while thiazolidine-2,4-dione is generally soluble in polar solvents, specific conditions such as solvent choice, pH, and temperature need to be considered to maximize its solubility for various uses.