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Tetrahydropyran-2-ylmethanol

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Identification
Molecular formula
C6H12O2
CAS number
5940-79-0
IUPAC name
tetrahydropyran-2-ylmethanol
State
State

At room temperature, tetrahydropyran-2-ylmethanol is typically found as a liquid.

Melting point (Celsius)
39.00
Melting point (Kelvin)
312.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
116.16g/mol
Molar mass
116.1580g/mol
Density
1.0380g/cm3
Appearence

Tetrahydropyran-2-ylmethanol appears as a colorless liquid. It is often clear and may appear slightly viscous.

Comment on solubility

Solubility of Tetrahydropyran-2-ylmethanol

Tetrahydropyran-2-ylmethanol (C7H14O) exhibits intriguing solubility characteristics that stem from its structural features. Being a cyclic ether, its solubility can largely be influenced by its molecular interactions with solvents.

  • Polarity: The presence of the hydroxyl (-OH) group in tetrahydropyran-2-ylmethanol contributes to its polarity, enhancing its ability to dissolve in polar solvents.
  • Solvent Interactions: Tetrahydropyran-2-ylmethanol is generally soluble in water and other alcohols, while less soluble in nonpolar solvents like hydrocarbons.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules increases its solubility, making it a viable compound in various chemical environments.

In summary, when considering the solubility of tetrahydropyran-2-ylmethanol, one must account for the balance between its hydrophilic and hydrophobic regions. As a result, this compound serves as an interesting example of how molecular structure directly affects solubility in different environments.

Interesting facts

Interesting Facts About Tetrahydropyran-2-ylmethanol

Tetrahydropyran-2-ylmethanol is an intriguing compound that belongs to the family of cyclic ethers, which play a vital role in various branches of chemistry and biochemistry. Here are some key insights into this fascinating chemical:

  • Structural Uniqueness: Tetrahydropyran is a six-membered ring containing one oxygen atom. The "2-yl" in its name indicates that the hydroxymethyl group (–CH2OH) is attached at the second carbon of the tetrahydropyran ring, creating a unique stereochemical environment that can influence the compound's reactivity.
  • Applications in Organic Synthesis: This compound is valuable in organic synthesis. It can be used as an intermediate in the production of various pharmaceuticals and other organic compounds. Its structure can be modified to create derivatives with specific desired properties.
  • Role in Glycosylation Reactions: Tetrahydropyran derivatives are often involved in glycosylation reactions, where sugars are linked to other molecules. This process is fundamental in the formation of many natural products, including antibiotics and other biologically active substances.
  • Biological Significance: Compounds like tetrahydropyran-2-ylmethanol are of interest in medicinal chemistry due to their potential biological activities. By modifying their structure, researchers aim to enhance their efficacy and reduce side effects in therapeutic applications.
  • Research Potential: Ongoing studies continue to explore the potential of tetrahydropyran-2-ylmethanol and its derivatives in different fields, including materials science and drug development, highlighting the importance of this compound in advancing scientific knowledge.

With its unique structure and versatile applications, tetrahydropyran-2-ylmethanol represents an exciting area of study for chemists and students alike. As noted by one researcher, "Compounds like this bridge the gap between theoretical chemistry and practical application, demonstrating the beauty of molecular design."

Synonyms
TETRAHYDROPYRAN-2-METHANOL
100-72-1
oxan-2-ylmethanol
2H-Pyran-2-methanol, tetrahydro-
(oxan-2-yl)methanol
2-Hydroxymethyltetrahydropyran
2-(Hydroxymethyl)tetrahydropyran
Tetrahydropyran-2-carbinol
Pyran-2-methanol, tetrahydro-
(Tetrahydro-2H-pyran-2-yl)methanol
2-Methanol tetrahydropyran
2-Tetrahydropyranilcarbinol
Tetrahydropyranyl-2-methanol
2-Methyloltetrahydro-1,4-pyran
Tetrahydropyran-2-ylmethanol
Tetrahydro-2H-pyran-2-methanol
NSC 5221
Tetrahydro-2H-pyran-2-ylmethanol
2-Methanol, tetrahydropyran
EINECS 202-882-4
JR71SUM5E9
BRN 0102998
AI3-14307
NSC-5221
MFCD00006624
5-17-03-00136 (Beilstein Handbook Reference)
WLN: T6OTJ B1Q
2-(HYDROXYMETHYL)TETRAHYDROPYRAN, (+/-)-
NSC 5221; NSC 66493; Oxan-2-ylmethanol; Tetrahydro-2H-pyran-2-ylmethanol; Tetrahydropyran-2-carbinol; Tetrahydropyran-2-methanol
UNII-JR71SUM5E9
MFCD22681529
MFCD22681530
Tetrahydropyran2carbinol
2Methanol tetrahydropyran
2Tetrahydropyranilcarbinol
Tetrahydropyran2ylmethanol
Tetrahydropyranyl2methanol
Pyran2methanol, tetrahydro
2-Hydromethyltetrahydropyran
2Methyloltetrahydro1,4pyran
tetrahydro-2-pyranylmethanol
2Hydroxymethyltetrahydropyran
2HPyran2methanol, tetrahydro
SCHEMBL226684
2-hydroxymethyl-tetrahydropyran
(tetrahydropyran-2-yl)methanol
tetrahydro-pyran-2-yl-methanol
ROTONRWJLXYJBD-UHFFFAOYSA-
DTXSID40870441
NSC5221
CHEBI:228990
Tetrahydropyran-2-methanol, 98%
ALBB-020943
BCP29810
NSC66493
Tetrahydro-2-hydroxymethyl-2H-pyran
Tetrahydro-2H-pyran-2-ylmethanol #
NSC-66493
2-(Hydroxymethyl)tetrahydro-2H-pyran
AKOS000120206
AKOS016843228
AB00784
FT03071
SB22788
(TETRAHYDRO-PYRAN-2-YL)-METHANOL
AS-53912
SY003220
SY259742
SY260760
3,4,5,6-tetrahydro-2H-pyran-2-methanol
HY-115051
CS-0034490
NS00015511
T0952
EN300-20690
P17277
Q27281647
F0001-0026
Z104479808
InChI=1/C6H12O2/c7-5-6-3-1-2-4-8-6/h6-7H,1-5H2
2-Tetrahydropyranilcarbinol;2-Methanol tetrahydropyran;(oxan-2-yl)methanol;Tetrahydro-2H-pyran-2-methanol