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γ-Butyrolactone

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Identification
Molecular formula
C4H6O2
CAS number
96-48-0
IUPAC name
tetrahydrofuran-2-one
State
State

At room temperature, γ-butyrolactone is a liquid. Its fluidity and water solubility make it versatile for use in various applications, including as a solvent and in chemical synthesis processes.

Melting point (Celsius)
-45.00
Melting point (Kelvin)
228.00
Boiling point (Celsius)
204.00
Boiling point (Kelvin)
477.00
General information
Molecular weight
86.09g/mol
Molar mass
86.0890g/mol
Density
1.1290g/cm3
Appearence

γ-Butyrolactone is a colorless, hygroscopic liquid with a weak characteristic odor. It is a non-corrosive compound and is soluble in water and a variety of organic solvents such as ethanol, acetone, and benzene.

Comment on solubility

Solubility of Tetrahydrofuran-2-one

Tetrahydrofuran-2-one, commonly known as butyrolactone, showcases interesting solubility characteristics that merit attention:

  • Polar solvents: Tetrahydrofuran-2-one is highly soluble in polar solvents such as water, ethanol, and methanol. Its polar nature allows it to interact favorably with other polar molecules.
  • Non-polar solvents: It is less soluble in non-polar solvents like hexane due to the lack of significant interactions between the polar lactone and non-polar molecules.
  • Concentration effects: The solubility of tetrahydrofuran-2-one tends to increase with temperature, making it more soluble at elevated temperatures, which is a key factor in various chemical processes.

In summary, the solubility of tetrahydrofuran-2-one is characterized by its strong affinity for polar solvents, while showing limited solubility in non-polar environments. This property makes it a valuable compound in various applications, particularly in organic synthesis and as a solvent in different chemical reactions.

Interesting facts

Interesting Facts About Tetrahydrofuran-2-one

Tetrahydrofuran-2-one, commonly referred to as THF-2-one, is a fascinating compound that belongs to the category of lactones. It is a cyclic ester that plays a crucial role in various chemical processes. Here are some compelling facts about this compound:

  • Versatile Solvent: THF-2-one is known for its ability to solvate a wide range of chemical substances, making it an excellent solvent in organic chemistry.
  • Intermediate in Synthesis: This compound serves as a key intermediate in the synthesis of polymers and pharmaceuticals, showcasing its importance in industrial applications.
  • Applications: THF-2-one has been utilized in the production of biodegradable plastics, enhancing environmental sustainability in material science.
  • Reactivity: The structure of THF-2-one allows for various chemical reactions, including nucleophilic attacks and rearrangements, which are significant in organic synthesis.
  • Biological Relevance: Research has indicated that compounds similar to THF-2-one can exhibit antimicrobial properties, hinting at potential applications in medicine.

As noted by chemistry researchers, "Understanding compounds like tetrahydrofuran-2-one not only broadens our knowledge of organic chemistry but also opens up new avenues for innovation in sustainable practices."

In conclusion, Tetrahydrofuran-2-one exemplifies the intricate connections between chemistry and real-world applications, highlighting the importance of exploring such compounds in scientific research.

Synonyms
gamma-Butyrolactone
96-48-0
BUTYROLACTONE
dihydrofuran-2(3H)-one
4-Butyrolactone
4-Butanolide
1,4-Butanolide
2-Oxolanone
4-Hydroxybutyric acid lactone
4-Deoxytetronic acid
Butyrylactone
2(3H)-Furanone, dihydro-
Dihydro-2(3H)-furanone
1,2-Butanolide
Butyryl lactone
Butyric acid lactone
oxolan-2-one
Tetrahydro-2-furanone
g-Butyrolactone
BLON
gamma-BL
4-Hydroxybutanoic acid lactone
Dihydro-2-furanone
1,4-Lactone
Agrisynth BLO
gamma-Hydroxybutyric acid lactone
gamma-Hydroxybutyrolactone
2-Oxotetrahydrofuran
.gamma.-Butyrolactone
NCI-C55878
gamma-6480
GBL
FEMA No. 3291
1-Oxacyclopentan-2-one
gamma Butyrolactone
gamma-Butyrolactone-13C4
NSC 4592
gamma-Butanolactone
gamma-Hydroxybutyric Acid cyclic ester
1,4-Butyrolactone
.gamma.-BL
Butyric acid, 4-hydroxy-, gamma-lactone
.gamma.-6480
BLO
.gamma.-Hydroxybutyrolactone
OL659KIY4X
DTXSID6020224
CHEBI:42639
.gamma.-Hydroxybutyric acid lactone
Butyrolactone-d6
NSC-4592
4-Hydroxybutyric acid, .gamma.-lactone
.gamma.-Hydroxybutyric acid cyclic ester
4-Hydroxybutanoic acid, .gamma.-lactone
Gammabutyrolactone (GBL)
gama-Butyrolactone
DTXCID80224
No Go
Caswell No. 132B
gamma-Butalactone
gamma-butyrolacton
Paint Clean G
CAS-96-48-0
31213-03-3
gamma-Butyryllactone
gamma-Butyrolactone (natural)
CCRIS 2924
gamma-Butyrolactone; GBL; Gammabutyrolactone
tetrahydrofuran-2-one
HSDB 4290
EINECS 202-509-5
UNII-OL659KIY4X
EPA Pesticide Chemical Code 122303
Revivarant
Remforce
4 Hydroxybutyric Acid Lactone
Butanoic acid, 4-hydroxy-, gamma-lactone
g-Butalactone
4-butanolactone
AI3-28121
g-Butyryllactone
GH Revitalizer
Blue Nitro
gammabutyrolactone
tetrahydrofuranone
4-Deoxytetronate
C-1070
Dihyro-2-furanone
dihydrofuran-2-one
gamma-butyro-lactone
NIH 10540
dihydro-furan-2-one
.alpha.-Butyrolactone
.gamma.-Butanolactone
2(3H)-dihydrofuranone
1-Oxacyclopentane-2-one
WLN: T5OVTJ
BUTYROLACTONE [MI]
EC 202-509-5
BUTYROLACTONE [VANDF]
Dynasolve 699 (Salt/Mix)
g-Hydroxybutyric acid lactone
CHEMBL95681
Dihydro-(3 H)-furan-2-one
Butyric acid, .gamma.-lactone
BUTYROLACTONE [WHO-DD]
GTPL5462
Butanoic acid, .gamma.-lactone
4,5-Dihydro-2(3H)-furanone
GAMMA-BUTYROLACTONE [FCC]
NSC4592
2,3,4,5-Tetrahydro-2-furanone
4-hydroxy-Butanoic acid g-lactone
GAMMA-BUTYROLACTONE [HSDB]
GAMMA-BUTYROLACTONE [IARC]
CDA56865
Gamma-Lactone 4-hydroxybutyric acid
YIB48692
ZYB44194
.gamma.-Hydrooxybutyric acid lactone
gamma-Butyrolactone, >=99% (GC)
Tox21_200490
Tox21_300188
Gamma-Lactone 4-hydroxy-butyric acid
Gamma-Lactone 4-hydroxybutanoic acid
LBG 11785
LMFA07040004
MFCD00005386
STL281877
.GAMMA.-BUTYROLACTONE [FHFI]
AKOS000119924
Gamma-Lactone 4-hydroxy-butanoic acid
DB04699
FB03390
gamma-Butyrolactone, analytical standard
NCGC00247920-01
NCGC00247920-02
NCGC00253913-01
NCGC00258044-01
Butyric acid, 4-hydroxy-, .gamma.-lactone
B0767
Butanoic acid, 4-hydroxy-, .gamma.-lactone
NS00003450
gamma-Butyrolactone, ReagentPlus(R), >=99%
C01770
gamma-Butyrolactone, puriss., >=99.0% (GC)
Q79739
gamma-Butyrolactone, SAJ first grade, >=99.5%
4-Hydroxybutanoic acid lactone, >=98%, FCC, FG
GBL (gamma-Butyrolactone), 10mg/ml in Acetonitrile
GBL (gamma-Butyrolactone), 1mg/ml in Acetonitrile
GBL (gamma-Butyrolactone), 50mg/ml in Acetonitrile
gamma-Butyrolactone (GBL) 1.0 mg/ml in Acetonitrile
GBL (gamma-Butyrolactone), 100mg/ml in Acetonitrile
InChI=1/C4H6O2/c5-4-2-1-3-6-4/h1-3H
BUTANOIC ACID,4-HYDROXY,LACTONE GAMMA-BUTYROLACTONE
GBL;gamma-Hydroxybutyric acid lactone;4-Hydroxybutyric acid lactone
BL