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Clopidogrel

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Identification
Molecular formula
C16H16ClNO2S
CAS number
120202-66-6
IUPAC name
sodium;6-[6-amino-8-(4-chlorophenyl)sulfanyl-purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
State
State

At room temperature, Clopidogrel is found in a solid state.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
581.70
Boiling point (Kelvin)
854.85
General information
Molecular weight
419.90g/mol
Molar mass
419.9000g/mol
Density
2.4000g/cm3
Appearence

Clopidogrel is typically encountered as a white to off-white crystalline powder.

Comment on solubility

Solubility of Sodium; 6-[6-amino-8-(4-chlorophenyl)sulfanyl-purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

The solubility of the compound with the chemical formula C16H16ClNO2S can be assessed by considering various factors influencing its dissolution in solvents. Here are some key observations:

  • Polarity: This compound contains several polar functional groups, such as amine (-NH2), sulfonyl (-SO2), and carbonyl (C=O) groups, which can enhance its solubility in polar solvents, particularly water.
  • Hydrophobic Regions: The presence of larger hydrophobic aromatic (4-chlorophenyl) and furan ring structures may reduce solubility in highly polar solvents, leading to a potential preference for lipophilic (fat-loving) environments.
  • pH Sensitivity: As a compound containing amino and hydroxyl groups, its solubility might vary significantly with pH, indicating that an ionizable form may render it more soluble in water under certain conditions.
  • Temperature Effects: Generally, increased temperature can improve solubility, particularly for solid compounds, suggesting that heating may enhance its dissolution rate in various solvents.

In conclusion, while the overall solubility of this complex compound may favor polar solvents due to its functional groups, the hydrophobic characteristics of its structure could pose challenges in achieving optimal dissolution. As stated in solubility science, “like dissolves like,” meaning the best solubility will likely occur in solvents that closely match the compound's polarity profile.

Interesting facts

Interesting Facts about Sodium; 6-[6-amino-8-(4-chlorophenyl)sulfanyl-purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

This compound, known for its complexity and multitude of functional groups, plays a significant role in various fields of research and application. Here are some intriguing aspects of this unique compound:

  • Pharmacological Potential: Due to its purine structure, this compound has been studied for its potential applications in pharmaceuticals, particularly as an antiviral or anticancer agent. The incorporation of a chlorophenyl group enhances its biological activity.
  • Mechanism Insights: The presence of amino and sulfanyl groups suggests potential interactions at the molecular level, making it a subject of interest for understanding enzyme inhibition and receptor binding.
  • Chirality and Stereochemistry: The tetrahydro structure indicates the possibility of stereoisomers, which can exhibit different biological activities. This aspect is essential when designing drugs that target specific pathways.
  • Environmental Considerations: Research on the biodegradation of similar phosphinine compounds can provide insights into their environmental impact. Understanding the breakdown of such compounds is crucial for sustainable chemistry.
  • Advanced Syntheses: The synthesis of this compound involves intricate organic reactions and strategies that can be a great topic of discussion in advanced chemistry courses, especially when it comes to multi-step synthesis processes.

In summary, sodium; 6-[6-amino-8-(4-chlorophenyl)sulfanyl-purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol is not just a chemical entity; it embodies a breadth of research potential and demonstrates the vastness of organic chemistry’s capabilities. As one researcher noted, "The beauty of chemistry lies in the endless possibilities that each compound presents for discovery and innovation."

Synonyms
8-CPT-cAMP (sodium salt)
8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphate
HMS3370B15
AKOS040744910
8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate