Interesting facts
Interesting Facts About S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-spiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-tetrahydrofuran]-7-yl] ethanethioate
This intriguing compound belongs to a class of molecules featuring a complex spirocyclic structure which gives it impressive properties and potential applications. Here are some interesting facts about this chemical compound:
- Sterochemistry: The designation of this compound features multiple stereocenters indicated by its systematic nomenclature, highlighting its chirality. Stereochemical configurations play a vital role in pharmacology, affecting how compounds interact with biological systems.
- Natural Sources: Compounds with similar structures often exist in nature, produced by various plants as secondary metabolites. Studying these compounds can lead to discoveries of novel therapeutic agents.
- Potential Applications: The unique spirocyclic framework makes this compound a candidate for use in the development of pharmaceuticals, agrochemicals, or even functional materials. Researchers continue to investigate how modifications to such structures can enhance their efficacy.
- Reactivity: The presence of functional groups such as dioxo and thioate implies that this compound may undergo interesting chemical reactions. It could participate in nucleophilic substitutions or be involved in the formation of more complex derivatives.
- Research Significance: The compound's complexity presents a challenge and an opportunity for synthetic chemists. Discovering efficient synthetic routes can lead to advancements in organic synthesis methodologies.
In summary, the fascinating structure and properties of S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-spiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-tetrahydrofuran]-7-yl] ethanethioate not only sparks interest in academic research but may also pave the way for innovative applications in various fields.
Synonyms
spironolactone
52-01-7
Aldactone
Spirolactone
Verospirone
Euteberol
Verospiron
Spirolang
Acelat
Spironocompren
Melarcon
Spiresis
Spiridon
Spiroctan
Uractone
Urusonin
Alderon
Spirone
Xenalon
Dira
Spiro-Tablinen
Aldactone A
Spironolactone A
spironolattone
Espironolactona
Spironolactonum
Aldopur
Aquareduct
Almatol
Deverol
Aldace
Altex
Berlactone
Diatense
SC 9420
Spironolactonum [INN-Latin]
Espironolactona [INN-Spanish]
Spironolactone ceva
SC-9420
spirotone
Carospir
HSDB 3184
EINECS 200-133-6
MFCD00082250
NSC 150399
NSC-150399
BRN 0057767
CHEBI:9241
DTXSID6034186
UNII-27O7W4T232
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
27O7W4T232
CHEMBL1393
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
Veroshpiron
DTXCID4014186
SC9420
4-18-00-01601 (Beilstein Handbook Reference)
Spironolactone [USP:INN:BAN:JAN]
Spironolattone [DCIT]
NSC150399
17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone acetate
3'-(3-Oxo-7-alpha-acetylthio-17-beta-hydroxyandrost-4-en-17-beta-yl)propionic acid lactone
SNL
CARDALIS COMPONENT SPIRONOLACTONE
SPIRONOLACTONE COMPONENT CARDALIS
Aldactide
ALDACTAZIDE COMPONENT SPIRONOLACTONE
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
Spiro(17H-cyclopenta(a)phenanthrene-17,2'(5'H)-furan), pregn-4-ene-21-carboxylic acid deriv.
Spironolactonum (INN-Latin)
SC 15983
SPIRONOLACTONE (IARC)
SPIRONOLACTONE [IARC]
C24H32O4S
Espironolactona (INN-Spanish)
SPIRONOLACTONE (MART.)
SPIRONOLACTONE [MART.]
SPIRONOLACTONE (USP-RS)
SPIRONOLACTONE [USP-RS]
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spironolactone (USP:INN:BAN:JAN)
SPIRONOLACTONE (EP MONOGRAPH)
SPIRONOLACTONE [EP MONOGRAPH]
SPIRONOLACTONE (USP MONOGRAPH)
SPIRONOLACTONE [USP MONOGRAPH]
Aldactone (TN)
S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
SMR000471892
SPIRONOLACTONE (EMA EPAR VETERINARY)
SPIRONOLACTONE [EMA EPAR VETERINARY]
Spiranolactone
Qaialdo
2oax
3vhu
CAS-52-01-7
NCGC00015948-02
3-(3-Keto-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alpha.-yl)propionic acid lactone
7-.alpha.-(acetylthio)-17-.alpha.-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, .gamma.-lactone
Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Spironolactone (Standard)
SPIRONOLACTONE [MI]
3-(3-Keto-7-alpha-acetylthio-17-beta-hydroxy-4-androsten-17-alpha-yl)propionic acid lactone
SPIRONOLACTONE [INN]
SPIRONOLACTONE [JAN]
BIDD:PXR0071
SCHEMBL20939
BSPBio_000176
SPIRONOLACTONE [HSDB]
17alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7alpha-mercapto-3-oxo-, gamma-lactone, acetate
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
MLS002548846
SPIRONOLACTONE [VANDF]
SPBio_002115
BPBio1_000194
GTPL2875
SPIRONOLACTONE [WHO-DD]
SPIRONOLACTONE [WHO-IP]
HY-B0561R
C03DA01
Spironolactone (JP17/USP/INN)
GLXC-10093
HMS1568I18
HMS2090N21
HMS2095I18
HMS2236E06
HMS3259G11
HMS3712I18
Spironolactone - Bio-X trade mark
HY-B0561
Spironolactone, 97.0-103.0%
SPIRONOLACTONE [ORANGE BOOK]
Tox21_113047
Tox21_302154
BDBM50228080
HB2799
MSK000578
s4054
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
AKOS015896401
SPIRONOLACTONUM [WHO-IP LATIN]
AC-4214
CCG-220128
DB00421
FS15791
KS-5234
NC00482
7-alpha-(acetylthio)-17-alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, gamma-lactone
NCGC00015948-10
NCGC00164397-01
NCGC00164397-02
NCGC00164397-03
NCGC00164397-05
NCGC00255229-01
(1'S,2R,2'R,9'R,10'R,11'S,15'S)-9'-(acetylsulfanyl)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan]-6'-ene-5,5'-dione
17-alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7-alpha-mercapto-3-oxo-, gamma-lactone acetate
BS166385
CPD000471892
Spironolactone 1.0 mg/ml in Acetonitrile
AB00513806
NS00000424
S0260
SPIRONOLACTONE COMPONENT OF ALDACTAZIDE
C07310
C75438
D00443
EN300-123035
AB01275520-01
AB01275520_02
Q422188
SR-01000765419
SR-05000000452
SR-01000765419-2
SR-05000000452-2
BRD-K90027355-001-03-4
BRD-K90027355-001-13-3
BRD-K90027355-001-19-0
Z1546616196
Spironolactone, European Pharmacopoeia (EP) Reference Standard
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
17.alpha.-Pregn-4-ene-21-carboxylic acid, .gamma.-lactone acetate
7alpha-Acetylsulfanyl-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
SPIRO(17H-CYCLOPENTA(A)PHENAUTHRENE-17,2'-(3'H)-FURAN
Spironolactone, United States Pharmacopeia (USP) Reference Standard
17.alpha.-Pregn-4-ene-21-carboxylic acid, .gamma.-lactone, acetate
Pregn-4-ene-21-carboxylic acid, .gamma.-lactone, (7.alpha.,17.alpha.)-
7alpha-(Acetylthio)-17alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid gamma-lactone
Spironolactone for system suitability, European Pharmacopoeia (EP) Reference Standard
(1R,3aS,3bR,4R,9aR,9bS,11aS)-4-(acetylsulfanyl)-9a,11a-dimethyl-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione
(7alpha,17alpha)-7-(Acetylthio)-17-hydroxy-3- oxopregn-4-ene-21-carboxylic acid gamma-lactone
2'',15''-dimethyl-5,5''-dioxo-(9''R)-spiro[tetrahydrofuran-2,14''-tetracyclo[8.7.0.02,7.011,15]heptadec-6''-ene]-9-yl ethanethioate
2'',15''-dimethyl-5,5''-dioxospiro[tetrahydrofuran-2,14''-tetracyclo[8.7.0.02,7.011,15]heptadec-6''-ene]-9-yl ethanethioate
2'',15''-dimethyl-5,5''-dioxospiro[tetrahydrofuran-2,14''-tetracyclo[8.7.0.02,7.011,15]heptadec-6''-ene]-9-yl ethanethioate(Spiranolactone)
200-133-6
PREGN-4-ENE-21-CARBOXYLIC ACID, 7-(ACETYLTHIO)-17-HYDROXY-3-OXO-,.GAMMA.-LACTONE, (7.ALPHA.,17.ALPHA.)-
S-(2''R,7R,8R,9S,10R,13S,14S)-10,13-dimethyl-3,5''-dioxo-1,2,3,4'',5'',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3''H-spiro[cyclopenta[a]phenanthrene-17,2''-furan]-7-yl ethanethioate
Solubility of S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-spiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-tetrahydrofuran]-7-yl] ethanethioate
The solubility of S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-spiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-tetrahydrofuran]-7-yl] ethanethioate (C24H32O4S) is a complex topic due to the intricate structure of the compound. Several factors influence the solubility characteristics:
In summary, the solubility of this compound can be predicted to be moderate in organic solvents and limited in water, emphasizing the importance of considering the solvent choice during practical applications. As always, empirical testing is essential for accurate solubility data.