Skip to main content

Primaquine bisulfate

ADVERTISEMENT
Identification
Molecular formula
C20H30N2O8S
CAS number
69-13-0
IUPAC name
(S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol;sulfuric acid
State
State

At room temperature, primaquine bisulfate is in the solid state, appearing as a crystalline powder.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
251.00
Boiling point (Kelvin)
524.15
General information
Molecular weight
455.50g/mol
Molar mass
455.5000g/mol
Density
1.2750g/cm3
Appearence

Primaquine bisulfate appears as a white or slightly pink, crystalline powder. It is soluble in water and in dilute sulfuric acid, but it is generally insoluble in ether, chloroform, and benzene.

Comment on solubility

Solubility of (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol; sulfuric acid

The solubility of the compound (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol with its associated sulfuric acid can be influenced by a variety of factors. Understanding its solubility characteristics is crucial for applications in pharmaceuticals and organic synthesis.

Key Factors Affecting Solubility:

  • Polarity: The presence of different functional groups, such as methoxy and quinuclidinyl, contributes to varying degrees of polarity, which can affect interaction with solvents.
  • Hydrogen Bonding: The capability of forming hydrogen bonds due to hydroxyl (-OH) groups in the structure can enhance solubility in polar solvents.
  • Temperature: Generally, an increase in temperature can result in higher solubility for many compounds due to enhanced molecular interactions.
  • pH of the Solution: The acidic environment created by sulfuric acid may facilitate greater solubility for specific ionic or polar forms of the compound.

In many cases, compounds that exhibit multiple functional groups may show enhanced solubility in a range of solvents, particularly in polar solvents. For C20H30N2O8S, one might expect:

  • **Increased solubility** in aqueous acidic solutions due to protonation effects.
  • Limited solubility in non-polar solvents, considering the significant size and structure of the compound.

Ultimately, the solubility profile of this compound can be highly context-dependent, largely influenced by the solvent system, temperature, and the ionic environment.

Interesting facts

Interesting Facts About (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol; sulfuric acid

This compound features a fascinating blend of elements that illustrates the complexity of organic chemistry and its applications. Here are some captivating insights:

  • Structure and Functionality: The compound includes a quinoline and quinuclidine moiety, which combine to offer multiple sites for interaction with biological targets. This structure is known for its potential pharmacological properties.
  • Chirality: The presence of the S-configuration in the compound highlights the importance of chirality in drug design. Chiral molecules often have distinct biological activities compared to their mirror image counterparts, making them vital in the pharmaceutical industry.
  • Applications: Compounds like this one have been of interest in medicinal chemistry due to their potential as therapeutic agents. They may serve as precursors or lead compounds in the development of drugs for various diseases.
  • Mechanistic Insights: The interaction with sulfuric acid can result in protonation or sulfonation reactions, affecting the reactivity of the compound. Understanding these mechanisms helps chemists tailor the compound for specific reactions or therapeutic applications.
  • Research Implications: The unique combination of functional groups allows for exploration in synthesizing new derivatives, which can lead to the discovery of new bioactive compounds.

As a testament to the intricate designs found in chemistry, this compound not only showcases the beauty of its structural complexity but also serves as a reminder of the meticulous nature of scientific exploration. "In every molecule, there’s a story waiting to be told."

Synonyms
Quinidine sulfate
DTXSID80911600
HMS3263I19
CCG-222313
LP01009
EU-0101009
Q0010
Q 0875
Sulfuric acid--6'-methoxycinchonan-9-ol (1/2)
11034-22-3