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Phosphatidylinositol 3,4,5-triphosphate

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Identification
Molecular formula
C47H83O21P4S
CAS number
164439-66-3
IUPAC name
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] hexadecanethioate
State
State

At room temperature, Phosphatidylinositol 3,4,5-triphosphate is found integrated within cell membranes as part of the phospholipid bilayer. It is typically not obtained as a standalone pure substance due to its role in biological processes. Therefore, it is most functionally considered as a component of biological systems where it remains embedded within the lipid membrane structure.

Melting point (Celsius)
190.50
Melting point (Kelvin)
463.65
Boiling point (Celsius)
720.00
Boiling point (Kelvin)
993.15
General information
Molecular weight
1505.60g/mol
Molar mass
1 505.6000g/mol
Density
1.8500g/cm3
Appearence

Phosphatidylinositol 3,4,5-triphosphate is a phosphoinositide compound that typically appears as a part of the phospholipid bilayer and is not isolated as a pure substance for typical usage, making it hard to describe in terms of appearance compared to more traditional compound samples. It is often studied in the context of biological membranes, where it doesn't have a distinct independent appearance. During the isolation of phosphoinositides from biological membranes, it is part of lipid fractions appearing as a membrane component, thus not typically characterized by a distinct color or solid form outside this environment.

Comment on solubility

Solubility of S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] hexadecanethioate (C47H83O21P4S)

The solubility of S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] hexadecanethioate can be quite complex due to its intricate structure. Here are some key points regarding its solubility:

  • Polar Versus Non-Polar Regions: This compound features both polar functional groups, such as phosphate and amino groups, and large non-polar hydrocarbon chains, which can affect its solubility in various solvents.
  • Solubility in Water: It may exhibit limited solubility in water owing to its substantial hydrophobic portions, but the presence of polar groups can enhance its interaction with aqueous environments.
  • Organic Solvents: Solubility may improve in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), where the non-polar sections of the molecule can interact more favorably.
  • pH Dependence: The solubility is likely to be pH-dependent, particularly influenced by the protonation or deprotonation of amino or hydroxyl groups, which can change solubility characteristics.

In summary, the solubility of S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] hexadecanethioate is multi-faceted, making it a subject of interest for further studies in various solvent interactions.

Interesting facts

Interesting Facts about S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] hexadecanethioate

This compound, known for its complex structure and multiple functional groups, is a fascinating subject of study in the field of biochemistry. Here are some engaging facts about it:

  • Biological Significance: The presence of the 6-aminopurin-9-yl group indicates potential roles in biological systems, particularly in nucleic acid interactions and as a base in DNA/RNA.
  • Phosphorylation Dynamics: The compound includes several phosphoryl groups, which are crucial for energy transfer and signaling in cells, making it a candidate for studies in metabolic pathways.
  • Complexity in Structure: With a total of 47 carbons in the structure, its size and complexity can present interesting challenges in synthesis and analysis.
  • Potential Applications: Given its intricate functionalities, this compound might be investigated for pharmaceutical applications, especially in drug design targeting specific enzymes or receptors.
  • Structural Features: The thiol group from the hexadecanethioate moiety suggests a possibility for modifying surfaces or creating tethered biosensors.

Research on such compounds often unveils new avenues in therapeutic strategies and molecular design. As we explore its mechanisms, we may discover that the intricate relationships between its molecular components are key to unlocking its full potential.

Synonyms
SCHEMBL11940280
Q3361645
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-[[[[(3R)-3-[2-(2-hexadecanoylsulfanylethylcarbamoyl)ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propoxy]-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid