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Tenofovir disoproxil

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Identification
Molecular formula
C19H30N5O10P
CAS number
147127-20-6
IUPAC name
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-methylprop-2-enethioate
State
State

At room temperature, Tenofovir disoproxil typically exists as a solid.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
760.00
Boiling point (Kelvin)
1 033.15
General information
Molecular weight
519.43g/mol
Molar mass
519.4340g/mol
Density
1.4973g/cm3
Appearence

Tenofovir disoproxil is a white to off-white crystalline powder.

Comment on solubility

Solubility of S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-methylprop-2-enethioate

The solubility of the compound C19H30N5O10P can be influenced by various factors due to its complex structure. Here are some key points to consider:

  • Polarity: The presence of multiple functional groups such as amino, hydroxyl, and phosphorus groups contributes to the overall polarity of the compound, suggesting potential solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl groups can engage in hydrogen bonding, which may enhance solubility in water and other polar solvents.
  • Functional Groups: The compound contains several heteroatoms (e.g., nitrogen and oxygen) which can affect interactions with solvent molecules, potentially increasing solubility.
  • Practical Solubility: While theoretical considerations suggest favorable solubility, actual solubility should be empirically determined, as complex interactions in solution can affect behavior.

As a rule of thumb, "like dissolves like." Therefore, this compound is expected to be more soluble in polar solvents than in non-polar solvents, yet the detailed solubility behavior may require more extensive analysis under varying conditions to provide a comprehensive understanding.

Interesting facts

Exploring S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-methylprop-2-enethioate

This compound is a remarkable example of molecular complexity in the field of biochemistry. Known for its intricate design and multiple functional groups, it presents several unique properties and potential applications. Here are some engaging facts:

  • Structure Complexity: This compound features a multi-layered structure that integrates various biological motifs, including an aminopurine ring, hydroxyl groups, and phosphonate functionalities, which when combined, enable transformative biochemical interactions.
  • Biological Significance: The presence of the aminopurine moiety suggests potential roles in nucleic acid metabolism, which could make this compound a subject of interest in pharmacological research.
  • Phosphoryl Groups: The inclusion of multiple phosphoryl groups enhances the compound's reactivity, supporting the exploration of its applications in drug formulation and molecular targeting.
  • Potential for Therapeutic Use: Given its structural components, this compound could be investigated for its potential as an anti-cancer agent or in the modulation of metabolic pathways.
  • Recent Research: Studies are emerging that evaluate the compound's effectiveness in various biological assays, indicating a promising horizon in therapeutic chemistry.

As researchers delve deeper into the properties and potential applications of this compound, its multifaceted nature could contribute significantly to advancements in both pharmaceutical science and biochemical understanding. Keeping an eye on such intricate compounds, like S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-methylprop-2-enethioate, is crucial as they may unlock new avenues for research and therapeutic possibilities.

Synonyms
Methacrylyl-CoA (not stereospecified)
SCHEMBL17772880
DTXSID00863677
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-methylprop-2-enethioate
Q3066714
S-{1-[5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} 2-methylprop-2-enethioate