Skip to main content

Coenzyme A

ADVERTISEMENT
Identification
Molecular formula
C21H36N7O16P3S
CAS number
85-61-0
IUPAC name
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] methanethioate
State
State

Coenzyme A is typically a solid at room temperature. It is a stable compound when dry but may hydrolyze in aqueous solutions. It is often handled as a powder for biochemical applications, supplied in dry or lyophilized form.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
767.54g/mol
Molar mass
767.5350g/mol
Density
1.2810g/cm3
Appearence

Coenzyme A appears as a crystalline solid. It does not have a distinct color, typically appearing as a white or off-white powder. Due to its complex structure and biochemical origins, it does not exhibit distinct reflective properties or any characteristic odor.

Comment on solubility

Solubility of S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] methanethioate

The solubility of the compound with the chemical formula C21H36N7O16P3S is influenced by various structural features. Notably, this compound contains:

  • Amino groups that often enhance solubility in polar solvents due to their ability to form hydrogen bonds.
  • Phosphate groups which are highly polar and can significantly increase the solubility of compounds in aqueous solutions.
  • Aromatic and aliphatic components that may have variable effects on overall solubility depending on solvent characteristics.

It is essential to note that:

  1. The presence of multiple functional groups can lead to a high degree of hydrophilicity, suggesting good solubility in water.
  2. This compound may exhibit limited solubility in non-polar organic solvents due to polar functional groups dominating its structure.
  3. The overall molecular weight of the compound could also influence its solubility, with larger molecules generally having lower solubility.

As a result, the solubility of this compound is expected to be significantly greater in aqueous environments than in lipophilic solvents. This characteristic could be beneficial for pharmacological applications, where solubility in biological fluids is vital for effective drug delivery.

Interesting facts

Interesting Facts about S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] methanethioate

This compound is a fascinating example of the complexity found in the realm of chemical compounds, particularly within bio-organic chemistry. It encompasses several vital components that are essential to biological functions and pharmacological applications.

Key Features:

  • Structural Complexity: The compound contains multiple functional groups, including phosphate and amino groups, which are crucial for biological activity.
  • Phosphorylation: The presence of phosphonic and phosphorus-containing groups suggests potential roles in enzyme activation or inhibition, reflecting similar mechanisms found in natural biochemical pathways, such as those involved in nucleic acid synthesis.
  • Amino Group: The attached 6-aminopurine component highlights its relationship with nucleotides, which are fundamental for genetic material and cellular energy transfer.

This compound may serve as a potential lead in drug design, especially in targeting pathways involving nucleotides or modulating cell signaling mechanisms. In addition, the intricate linkage of methoxy and hydroxy groups hints at its potential for enhanced reactivity and interactions with biological macromolecules, making it a valuable asset in medicinal chemistry.

Applications and Implications:

  • Drug Development: Its unique structure may allow for the design of novel therapeutic agents.
  • Chemical Biology: Could serve as a powerful tool to study cellular mechanisms and pathways associated with nucleotide metabolism.
  • Biotechnological Uses: May find applications in gene therapy or biocatalysis due to its potential interactions within biochemical systems.

Ultimately, the exploration of such a compound can lead to discoveries that bridge the gap between chemistry and biology, opening new avenues for innovative treatments and insights into biochemical processes.

Synonyms
Formyl-coenzyme A; (Acyl-CoA); [M+H]+;
SCHEMBL17997996