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Tenofovir disoproxil

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Identification
Molecular formula
C19H30N5O10P
CAS number
147127-20-6
IUPAC name
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-phenylethanethioate
State
State

At room temperature, tenofovir disoproxil is typically in a solid state. The compound is susceptible to hydrolysis, especially under acidic or basic conditions, which can lead to degradation. It is important to store it properly to maintain its stability as a powder.

Melting point (Celsius)
107.00
Melting point (Kelvin)
380.00
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.00
General information
Molecular weight
519.40g/mol
Molar mass
519.4040g/mol
Density
1.4900g/cm3
Appearence

Tenofovir disoproxil is generally found in the form of its fumarate salt, which appears as a white to off-white crystalline powder. It may not possess a distinctive smell and is usually handled in solid form for pharmaceutical preparations.

Comment on solubility

Solubility of S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-phenylethanethioate

The solubility of the compound S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-phenylethanethioate (C19H30N5O10P) can be characterized as follows:

  • It exhibits a complex structure, which suggests a diverse range of interactions with solvents.
  • The presence of multiple hydroxyl groups and phosphoryl groups typically enhances solubility in polar solvents such as water.
  • On the other hand, the existence of aromatic and hydrophobic components can affect solubility in nonpolar solvents.
  • Based on its structure, the solubility might be heavily influenced by pH levels, as changes in ionic state can either promote or hinder solubility.

In summary, the exact solubility of this compound is dependent on various factors such as temperature, pH, and the presence of other ionic or polar substances in the solution. As noted, “solubility is a complex interplay of molecular structure and environmental conditions.” Therefore, it is important to conduct specific experiments to determine practical solubility limits.

Interesting facts

Interesting Facts about S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 2-phenylethanethioate

This compound is a complex example of synthetic biology chemistry and has significant implications in the fields of biochemistry and pharmacology. Here are some engaging facts about it:

  • Pharmaceutical Applications: The compound is studied for its potential in drug development, particularly in the treatment of various diseases due to its unique structure that incorporates purine derivatives.
  • Biological Role: It plays a critical role in several biological pathways, especially those involving nucleotides, suggesting potential use as a metabolic modulator.
  • Complex Synthesis: The synthesis of this compound involves multiple steps, showcasing the intricate processes chemists employ to build complex molecules.
  • Research Potential: Given its structural complexity, this compound is a subject of interest in pharmacological studies and might lead to innovative therapeutic agents.
  • Email Quote: “The synthesis of complex molecules like this not only enhances our understanding of chemical interactions but also paves the way for novel drug designs,” says a leading chemist in the field.

Furthermore, the incorporation of phosphonic acid groups presents interesting properties that affect the compound’s interaction with biological targets. Understanding these interactions at a molecular level can lead to significant advancements in both medicinal chemistry and drug therapies.

In summary, this compound embodies the connection between chemistry and biology, illustrating how intricate molecular structures can have profound impacts on health and medicine.

Synonyms
DTXSID40864087
HAA53239
S-{1-[5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} phenylethanethioate