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Pyrazine-2-carboxylic acid

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Identification
Molecular formula
C5H4N2O2
CAS number
98-97-5
IUPAC name
pyrazine-2-carboxylic acid
State
State

At room temperature, pyrazine-2-carboxylic acid is a solid.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
124.10g/mol
Molar mass
124.1100g/mol
Density
1.4720g/cm3
Appearence

Pyrazine-2-carboxylic acid appears as a white to off-white crystalline powder. It is a solid substance that is known for its characteristic structure that includes a pyrazine ring (a six-membered ring with two nitrogen atoms).

Comment on solubility

Solubility of Pyrazine-2-carboxylic Acid

Pyrazine-2-carboxylic acid (C5H4N2O2) exhibits notable solubility characteristics that are influenced by its molecular structure. Primarily used in biochemical applications, its solubility in various solvents can be summarized as follows:

  • Water: Pyrazine-2-carboxylic acid is generally soluble in water due to the presence of its carboxylic acid group, which can form hydrogen bonds with water molecules.
  • Organic Solvents: It is also soluble in polar organic solvents. Some common examples include:
    • Ethanol
    • Acetone
    • DMSO (Dimethyl sulfoxide)
  • Low Solubility in Non-Polar Solvents: The compound shows low to negligible solubility in non-polar solvents such as hexane and toluene, owing to the lack of polar interactions.

Overall, the solubility of pyrazine-2-carboxylic acid highlights the significance of functional groups in determining the behavior of organic compounds in different solvent systems. As expressed in the quote, “Like dissolves like,” the polar nature of this compound allows it to readily mix with other polar solvents, making it a versatile choice in many chemical processes.

Interesting facts

Interesting Facts about Pyrazine-2-Carboxylic Acid

Pyrazine-2-carboxylic acid is a fascinating compound belonging to the class of heterocyclic compounds, specifically pyrazines. Here are several intriguing aspects of this compound:

  • Chemical Structure: Pyrazine-2-carboxylic acid contains both a pyrazine ring and a carboxylic acid functional group. The presence of these different functional groups influences its chemical behavior and reactivity.
  • Biological Activity: Compounds like pyrazine-2-carboxylic acid have been studied for their various biological activities. Some derivatives exhibit antimicrobial properties, which makes them of interest in pharmaceutical research.
  • Role in Synthesis: This compound often serves as an important building block in organic synthesis, allowing chemists to create more complex molecules, particularly in the development of agrochemicals and pharmaceuticals.
  • Flavors and Fragrances: Pyrazines, including pyrazine-2-carboxylic acid, are known for their distinct flavors. They are typically associated with roasted or toasted notes, contributing to the aroma of various food products.
  • Research Importance: Ongoing research investigates the potential uses of pyrazine compounds in materials science, particularly in the development of conductive polymers and organic semiconductors due to their unique electronic properties.

In conclusion, pyrazine-2-carboxylic acid is not only integral to various chemical processes but also holds promise in several fields of research and application. Its unique structure and properties make it a noteworthy subject of study for chemists and industry professionals alike.

Synonyms
Pyrazine-2-carboxylic acid
2-Pyrazinecarboxylic acid
98-97-5
pyrazinoic acid
pyrazinecarboxylic acid
Pyrazinic acid
pyrazinemonocarboxylic acid
Paradiazinecarboxylic acid
2-Carboxypyrazine
2-Pyrazine carboxylic acid
Piazinecarboxylic acid
2-Pyrazinoic acid
MFCD00006130
PYRAZINE CARBOXYLIC ACID
Pyrazoic acid
2-pyrazinic acid
NSC 13146
UNII-2WB23298SP
CHEBI:71311
2WB23298SP
EINECS 202-718-1
NSC-13146
CHEMBL613
PYRAZINOIC ACID [MI]
MLS000069596
NIPZZXUFJPQHNH-UHFFFAOYSA-
DTXSID30243367
NSC13146
SMR000059041
Pyrazine-2-carboxylicacid
pyrazinoicacid
2Pyrazinoic acid
Pyrazine-2-carboxylic Acid; Pyrazinamide Imp. A (EP); Pyrazinamide Impurity A
VGL
2-Pyrazinecarboxylic
pyrazinecarboxylic acids
2pyrazinecarboxylic acid
pyrazine-carboxylic acid
Pyrazine2carboxylic acid
Opera_ID_935
2Pyrazine carboxylic acid
pyrazin-2-carboxylic acid
pyrazine 2-carboxylic acid
2- carboxylic acid pyrazine
SCHEMBL23757
Pyrazinecarboxylic acid, 99%
CHEBI:48345
DTXCID30165858
HMS2234J12
HMS3371F05
CS-M0892
NSC27192
STR06281
BDBM50216541
CX1040
NSC-27192
STK802305
AKOS000119670
AC-2442
FP15650
PB27363
PS-3389
BP-30070
HY-76353
SY001166
DB-025265
NS00041381
P0940
EN300-19900
C19915
Pyrazinecarboxylic acid, purum, >=98.0% (T)
AB-131/40186434
Q7263414
F2191-0112
Z104476002