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Amlodipine

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Identification
Molecular formula
C20H25ClN2O5
CAS number
88150-42-9
IUPAC name
O5-cinnamyl O3-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
State
State

Amlodipine is commonly in a solid state at room temperature, often prepared in tablet form for medical administration.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
514.50
Boiling point (Kelvin)
787.70
General information
Molecular weight
408.88g/mol
Molar mass
408.8790g/mol
Density
1.1030g/cm3
Appearence

Amlodipine is typically found as a white to off-white crystalline powder. It is odorless and stable under normal conditions.

Comment on solubility

Solubility of O5-cinnamyl O3-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

The solubility of a compound in different solvents is a crucial aspect of its chemical behavior and potential applications. In the case of C20H25ClN2O5, several factors influence its solubility:

  • Polarity: This compound contains polar functional groups which may enhance its solubility in polar solvents such as water and alcohols.
  • Hydrophobic regions: The presence of the cinnamyl group suggests some hydrophobic characteristics, potentially reducing solubility in highly polar solvents.
  • Interactions: The compound’s ability to form hydrogen bonds due to its carboxylate and methoxy groups can improve solubility in specific solvents.

To summarize, the solubility of C20H25ClN2O5 may vary significantly depending on the solvent system due to the balance of hydrophilic and hydrophobic characteristics. It is likely to show:

  1. Good solubility in polar solvents due to its polar functional groups.
  2. Limited solubility in non-polar solvents because of its hydrophobic regions.

Understanding these solubility characteristics will aid in optimizing conditions for its use in various applications, thus demonstrating the importance of solubility in the study of chemical compounds.

Interesting facts

Interesting Facts about O5-cinnamyl O3-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

This unique compound is a member of the dihydropyridine family, which is known for its significant pharmacological activities. Here are some noteworthy points about this fascinating chemical:

  • Pharmacological Potential: Compounds like this one possess the ability to act as calcium channel blockers, which are often used in the treatment of hypertension and other cardiovascular diseases.
  • Synthetic Versatility: The incorporation of nitrophenyl groups suggests that this compound could undergo various chemical transformations, making it a versatile building block for organic synthesis.
  • Functional Diversity: The presence of multiple functional groups, including methoxy, carboxylate, and nitro, indicates potential applications in drug design and development, particularly for targeting specific biochemical pathways.
  • Research Interest: Scientists are increasingly interested in the derivatives of dihydropyridines due to their roles in modulating biological activity and improving drug efficacy.

In conclusion, the study of O5-cinnamyl O3-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate highlights its potential in medicinal chemistry and pharmacology. As research continues, this compound may lead to the development of novel therapeutic agents, addressing various health challenges.

Synonyms
C27H28N2O7
CHEMBL4750597
HMS3269H05
HMS3651E07
HB1217
AKOS024457205
Q27163342
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl(2E)-3-phenyl-2-propenyl ester
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-(2-methoxyethyl) ester O5-(3-phenylprop-2-enyl) ester
2-methoxyethyl cinnamyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-(2-methoxyethyl) 5-(3-phenylprop-2-en-1-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate