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Promazine

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Identification
Molecular formula
C17H20N2S
CAS number
58-40-2
IUPAC name
N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
State
State

At room temperature, Promazine is in a solid state. It is commonly available as tablets or in powder form for pharmaceutical applications.

Melting point (Celsius)
124.00
Melting point (Kelvin)
397.15
Boiling point (Celsius)
494.60
Boiling point (Kelvin)
767.75
General information
Molecular weight
284.42g/mol
Molar mass
284.4300g/mol
Density
1.2210g/cm3
Appearence

Promazine appears as a pale yellow crystalline powder. It is typically odorless but may sometimes have a slight characteristic odor.

Comment on solubility

Solubility of N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine

The solubility of N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine (C17H20N2S) can vary significantly depending on environmental conditions. This compound contains both hydrophobic (phenothiazine moiety) and hydrophilic (amine group) characteristics, which can influence its solubility in different solvents.

Factors Influencing Solubility:

  • Polarity of Solvent: Being an amine can make it more soluble in polar solvents like water, but its substantial hydrophobic sections may limit this solubility.
  • Temperature: Increased temperatures typically enhance solubility for many compounds due to greater molecular movement.
  • pH Levels: Changes in pH can affect the ionization state of amines, potentially increasing their water solubility if protonated.
  • Presence of other solutes: The solubility can be affected by the presence of other ionic or non-ionic compounds in the solvent.

As a general observation, *"like dissolves like"*, meaning that the solubility of N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine would likely be greater in organic solvents compared to water. However, detailed experimental data would be crucial to accurately define its solubility profile.

Interesting facts

Exploring N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine

N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine, commonly referred to by its systematic name, is a fascinating chemical compound that occupies a unique space within the realm of organic chemistry. Here are several intriguing aspects of this compound:

  • Pharmacological Significance: This compound has shown potential in the field of medicinal chemistry, particularly in the development of new therapeutic agents. Its structure suggests activity that could be relevant in treating various psychiatric disorders.
  • Structural Complexity: The compound's structure features a phenothiazine ring, which is a core component found in various pharmaceutical drugs. Phenothiazines are known for their antipsychotic properties and serve as a blueprint for designing novel drugs.
  • Electron Delocalization: The phenothiazine moiety contributes to the compound’s electronic properties, allowing for electron delocalization. This aspect is important for understanding how the compound interacts with biological systems at the molecular level.
  • Synthetic Pathway: The synthesis of N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine can be intricate, typically involving multi-step reactions. Mastering these reactions provides invaluable experience in the lab for chemistry students.

As one delves deeper into the world of N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine, it becomes evident that compounds of this nature open doors to a myriad of applications, from pharmaceuticals to advanced materials science. Its vibrant chemistry is not just limited to theoretical discussions but is pivotal for ongoing research in the field. Exploring such compounds provides a glimpse into how nuanced changes in molecular structures can lead to significant advancements in science and medicine.

Synonyms
trimeprazine
Alimemazine
Methylpromazine
84-96-8
Alimezine
Repetin
Teralen
dl-Trimeprazine
Alimemazina
Bayer 1219
(+-)-Trimeprazine
Alimemazinum
Trimeperazine
Alimemazine [INN:BAN]
Alimemazinum [INN-Latin]
Alimemazina [INN-Spanish]
N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine
Alimemazine (INN)
Trimeprazine (BAN)
HSDB 3197
10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine
EINECS 201-577-3
RP 6549
BAYER-1219
10-(2-Methyl-3-dimethylaminopropyl)-phenothiazine
N,N,beta-Trimethyl-10H-phenothiazine-10-propanamine
76H78MJJ52
10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
ALIMEMAZINE [INN]
N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
TRIMEPRAZINE [MI]
ALIMEMAZINE [HSDB]
CHEMBL829
RP-6549
TRIMEPRAZINE [VANDF]
ALIMEMAZINE [WHO-DD]
Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-
CHEBI:9725
dimethyl[2-methyl-3-(10H-phenothiazin-10-yl)propyl]amine
Isobutrazine
DTXSID9023708
(+-)-Alimemazine
84-96-8 (FREE BASE)
10H-Phenothiazine-10-propanamine, N,N,.beta.-trimethyl-
Alimemazinum (INN-Latin)
Alimemazina (INN-Spanish)
10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine
Teralene
10H-PHENOTHIAZINE-10-PROPANAMINE N,N,.BETA.-TRIMETHYL-
Repeltin (TN)
NSC17476
Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-
dimethyl(2-methyl-3-(10H-phenothiazin-10-yl)propyl)amine
UNII-76H78MJJ52
Temaril (Salt/Mix)
Vanectyl (Salt/Mix)
Nedeltran (Salt/Mix)
Theralene (Salt/Mix)
Vallergan (Salt/Mix)
starbld0016703
(.+/-.)-Alimemazine
(.+/-.)-Trimeprazine
10-(3-Dimethylamino-2-methylpropyl)phenothiazine
SCHEMBL18993
(+/-)-ALIMEMAZINE
(+/-)-TRIMEPRAZINE
DTXCID903708
GTPL7237
N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
R06AD01
BDBM50062261
EX-A11949
AKOS015963415
DB01246
QTL1_000086
AC-19920
HY-12752
SBI-0051545.P002
AB00053560
CS-0012341
NS00008423
C07172
D07125
AB00053560_08
EN300-18553889
L000989
10-[2-Methyl-3-(dimethylamino)propyl]phenothiazine
Q2623251
BRD-A49225603-045-05-0
BRD-A49225603-045-10-0
Dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)-amine
10H-PHENOTHIAZINE-10-PROPANAMINE N,N,BETA-TRIMETHYL-
N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine #
201-577-3