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Flupentixol

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Identification
Molecular formula
C23H25F3O4
CAS number
2709-56-0
IUPAC name
N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide
State
State

At room temperature, Flupentixol exists as a solid. It is typically formulated into tablets for oral administration or converted into an injectable form for medical use.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
340.00
Boiling point (Kelvin)
613.15
General information
Molecular weight
434.60g/mol
Molar mass
434.5950g/mol
Density
1.2400g/cm3
Appearence

Flupentixol appears as a pale yellow, crystalline powder. It is commonly used in its dihydrochloride salt form which is more soluble in water. The appearance might slightly vary when it is in a different salt form.

Comment on solubility

Solubility of N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide

The solubility of the compound N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide (C23H25F3O4) plays a crucial role in its potential applications and behavior in various environments.

Generally, the solubility of such complex organic compounds can be influenced by several factors:

  • Polarity: The presence of sulfonamide groups often increases polarity, enhancing aqueous solubility.
  • Hydrogen Bonding: Functional groups capable of forming hydrogen bonds can significantly impact solubility in polar solvents.
  • Molecular Weight: Higher molecular weight can lead to decreased solubility due to increased van der Waals forces.
  • Temperature: Temperature variations can alter solubility, often increasing it with rising temperatures.

It is important to note that while some experimental data may be lacking, compounds of similar structure often exhibit varying degrees of solubility in solvents such as:

  • Water: Potential moderate solubility due to polar functional groups.
  • Organic Solvents: Likely higher solubility in organic solvents like ethanol or chloroform.

In conclusion, predicting the solubility of N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide requires consideration of its complex structure and the interactions among different functional groups. As a rule of thumb, substances with a balance between hydrophobic and hydrophilic characteristics tend to be more soluble in mixed environments.

Interesting facts

N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide: Interesting Facts

N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide is a fascinating compound with applications that extend into various fields of chemistry and pharmacology. Here are some captivating details:

  • Versatile Functionality: This compound features a thioxanthene core, which gives it unique photophysical properties. Thioxanthene derivatives are known for their ability to engage with light, making them potential candidates for applications like photodynamic therapy.
  • Biological Relevance: The presence of the 4-methylpiperazine moiety suggests that this compound may exhibit potential biological activity, often utilized in medicinal chemistry for developing novel therapeutics.
  • Sulfonamide Group: This significant functional group is known for its antimicrobial properties. The sulfonamide functionalization opens avenues for exploration in pharmaceutical synthesis.
  • Structural Complexity: The intricate structure of this compound demonstrates how substituents can dramatically influence the chemical properties and biological interactions of a molecule. Structural modifications can lead to variations in potency and efficacy.
  • Research Frontier: As a subject of ongoing research, compounds like this one are of great interest in studying receptor interactions, signaling pathways, and optimizing drug design.

In conclusion, N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide is more than just a chemical formula; it represents the convergence of advanced chemistry and potential therapeutic applications. As scientists continue to explore its characteristics, it opens up exciting possibilities in the realms of drug discovery and material science.

Synonyms
thiothixene
5591-45-7
Thiothixene [USAN:USP]
Orbinamon
Navan
HSDB 3402
N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide
EINECS 227-001-0
NSC 108165
P 4657B
Navaron
CP-12,252-1 base
Thiothixene (USAN:USP)
P-4657-B
DTXSID6023658
UNII-LF886533UR
2-(Dimethylsulfamoyl)-(9-(4-methyl-1-piperazinyl)propylidene)thioxanthene
N,N-Dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thioxanthene-2-sulfonamide
Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-
Spectrum_001068
Spectrum2_001333
Spectrum3_000581
Oprea1_774264
KBioSS_001548
NSC 108165; Navan; Navane; Navaron; Orbinamon; P 4657B
DivK1c_000335
SPBio_001485
CHEMBL2355126
KBio1_000335
KBio2_001548
KBio2_004116
KBio2_006684
KBio3_001522
(E)-N,N-dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulfonamide
NINDS_000335
HMS3372O10
HMS3749M15
LF886533UR
NS00004100
Q27165402
N,N-Dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulphonamide
N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-2-thioxanthenesulfonamide
cis-Thiothixene N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide