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Amitriptyline

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Identification
Molecular formula
C20H23N
CAS number
50-48-6
IUPAC name
N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
State
State
At room temperature, amitriptyline is generally in a solid crystalline state. Due to its chemical nature, it is readily soluble, which makes it adaptable for its use in various pharmaceutical applications as tablets and liquid form.
Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.15
General information
Molecular weight
277.40g/mol
Molar mass
277.4030g/mol
Density
1.0280g/cm3
Appearence
Amitriptyline is commonly encountered as a white or off-white crystalline powder. It is quite soluble in water, ethanol, and chloroform, and typically exhibits a mild odor.
Comment on solubility

Solubility of N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine

The compound N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine, with the chemical formula C20H23N, exhibits unique solubility characteristics due to its molecular structure.

Generally, the solubility of a compound is influenced by the following factors:

  • Polarity: Non-polar compounds tend to dissolve well in non-polar solvents, while polar compounds are more soluble in polar solvents. This compound's substantial non-polar characteristics suggest it may be soluble in organic solvents.
  • Molecular Size: The large size and complex structure of this compound could hinder its solubility in water, as larger molecules often struggle to interact favorably with water molecules.
  • Functional Groups: The presence of amine (–NH2) groups can contribute to a degree of solubility in polar solvents, yet the overall effectiveness can be modest compared to smaller, more straightforward amines.

Based on these considerations, one might say: "While this compound could demonstrate some solubility in specific solvents, particularly organic ones, its large molecular framework likely limits its solubility in water."

In conclusion, the solubility of N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine is expected to be variable, thus requiring careful consideration of both solvent type and conditions when assessing its solubility profile.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine

N,N-Dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine is a fascinating compound characterized by its complex structure and potential applications. Here are some compelling aspects about this compound:

  • Complex Structure: This compound features a unique tricyclic system, which contributes to its intricate configuration. The presence of the hexaenylidene fragment in its structure indicates a degree of unsaturation and the potential for interesting reactivity.
  • Potential Applications: Due to its structural characteristics, this compound may have applications in organic synthesis, medicinal chemistry, or material science. Compounds with similar frameworks are often explored for their properties in drug development and novel materials.
  • Research Interests: The combination of dimethylaminopropane and the tricyclic component might exhibit intriguing biochemical activities, making it a subject of interest for further scientific studies.
  • Structural Diversity: The complexity of this compound's geometry allows for numerous isomers, which can lead to varied chemical and physical properties. Exploring these isomers could yield discoveries valuable in both academic and industrial chemistry.

As noted by a renowned chemist, "The beauty of organic compounds lies not just in their diversity but in the endless possibilities they offer." This compound, with its rich structural profile, exemplifies that philosophy and bridges a world of research possibilities.

In conclusion, N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine stands as a testament to the complexity and potential of modern organic chemistry, beckoning researchers to delve deeper into its mysteries.

Synonyms
amitriptyline
50-48-6
Amitriptylin
Damitriptyline
Triptanol
Flavyl
Seroten
Proheptadiene
Lantron
Triptisol
Tryptanol
Adepress
Adepril
Damilen
Amitryptiline
Triptilin
Redomex
Amitriprolidine
Laroxyl
Amitriptilina
Amytriptylin
Amitriptylinum
Amitryptyline
Damilan
Laroxil
Ro 4-1575
MK 230
Sarotex
Amitriptylinum [INN-Latin]
Amitriptilina [INN-Spanish]
5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
CCRIS 9174
HSDB 3007
10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine
N 750
EINECS 200-041-6
BRN 2217885
CHEBI:2666
Amitriptyline (INN)
UNII-1806D8D52K
5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin
5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-
CHEMBL629
1806D8D52K
5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene
5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-
10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(sup 5),gamma-propylamine
DTXSID7022594
EC 200-041-6
5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene
10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(5),gamma-propylamine
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-
N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
Amytriptiline
Elanil
Amitriptylin [German]
5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene
Amitriptilina [Italian]
AMITRIPTYLINE [INN]
Amitriptylinum (INN-Latin)
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N,N-dimethyl-
Amitriptilina (INN-Spanish)
Amitriptyline [INN:BAN]
AMITRIPTYLINE (MART.)
AMITRIPTYLINE [MART.]
AMITRIPTYLINE (USP IMPURITY)
AMITRIPTYLINE [USP IMPURITY]
5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene
10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene
10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta5,gamma-propylamine
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
5H-Dibenzo[a,d]cycloheptene-.delta.5,.gamma.-propylamine, 10,11-dihydro-N,N-dimethyl-
TP0
Laroxyl (TN)
NCGC00015095-09
CAS-549-18-8
Elani
3-(10,11-dihydro-5H-dibenzo(a,d)(7)annulen-5-ylidene)-N,N-dimethylpropan-1-amine
3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
Domical (Salt/Mix)
Laroxyl (Salt/Mix)
Lentizol (Salt/Mix)
Vanatrip (Salt/Mix)
Triptizol (Salt/Mix)
Amitriptylinum (Latin)
Spectrum_000044
Prestwick0_000074
Prestwick1_000074
Prestwick2_000074
Prestwick3_000074
Spectrum2_000101
Spectrum3_000298
Spectrum4_000146
Spectrum5_000806
Lopac-A-8404
AMITRIPTYLINE [MI]
SCHEMBL7824
Lopac0_000112
Oprea1_479304
AMITRIPTYLINE [VANDF]
BSPBio_000287
BSPBio_001836
GTPL200
KBioGR_000592
KBioGR_002261
KBioSS_000424
KBioSS_002262
BIDD:GT0115
DivK1c_000766
SPBio_000082
SPBio_002208
AMITRIPTYLINE [WHO-DD]
BPBio1_000317
DTXCID502594
KBio1_000766
KBio2_000424
KBio2_002261
KBio2_002992
KBio2_004829
KBio2_005560
KBio2_007397
KBio3_001336
KBio3_002741
N06AA09
cMAP_000001
NINDS_000766
5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]-cycloheptadiene
BCP09083
HY-B0527
MSK10058
PS01 - Amitriptyline/Nortriptyline
BDBM50020712
MK-230
PDSP1_001564
PDSP2_001548
s5947
STK525215
5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene
5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,d]10,11-dihydrocycloheptene
AKOS000512694
CCG-204207
DB00321
SDCCGSBI-0050100.P005
IDI1_000766
MRF-0000533
NCGC00015095-01
NCGC00015095-02
NCGC00015095-03
NCGC00015095-04
NCGC00015095-05
NCGC00015095-06
NCGC00015095-07
NCGC00015095-08
NCGC00015095-10
NCGC00015095-11
NCGC00015095-12
NCGC00015095-14
NCGC00015095-26
NCGC00024433-04
NCGC00183047-01
1ST10058
DA-50424
dimethyl({3-[(2Z)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine
SBI-0050100.P004
3B - Known Drug Blood Quantification Sample
AB00514631
AmitriptylineMK-230, N-750, Ro41575
CS-0009498
NS00000032
C06824
D07448
Q58397
AB00053417-12
AB00053417_13
AB00053417_14
L001041
BRD-K53737926-003-05-4
BRD-K53737926-003-14-6
BRD-K53737926-003-25-2
BRD-K53737926-003-27-8
5-(3-Dimethylpropylidene)dibenzo(a,d)(1,4)cycloheptadiene
NORTRIPTYLINE HYDROCHLORIDE IMPURITY F [EP IMPURITY]
5-(.gamma.-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene
5-(.gamma.-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
5-(3-Dimethylaminopropylidene)-10,11-dihyro-5h-dibenzo(a,d)cycloheptene
10,11-Dihydro-5-(.gamma.-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
10,11-dihydro-N,N-dimethl-5H-dibenzo[a,d]cycloheptene-(delta(5, gamma))-propylamine
10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-.DELTA.5,.gamma.-propylamine
3-(5,6-dihydrodibenzo[[?],[?]][7]annulen-11-ylidene)-N,N-dimethyl-propan-1-amine
5-(.gamma.-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
5-(.gamma.-Dimethylaminopropylidene)-5H-dibenzo(a,d)-10,11-dihydrocycloheptene
5H-Dibenzo(a,d)cyclopheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-n,n-dimethyl-
N-[3-(10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDEN)PROPYL]-N,N-DIMETHYLAMINE
200-041-6
3-(10,11-Dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, hydrochloride
5H-Dibenzo(a,d)cycloheptene-.delta.(sup 5),.gamma.-propylamine, 10,11-dihydro-N,N-dimethyl-
5H-Dibenzo[a,d]cycloheptene-Delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl- (6CI,8CI) 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
dimethyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene]propyl})amine