Skip to main content

Bedaquiline

ADVERTISEMENT
Identification
Molecular formula
C32H31BrN2O2S
CAS number
843663-66-1
IUPAC name
N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine
State
State

Bedaquiline is typically found in a solid state at room temperature.

Melting point (Celsius)
129.50
Melting point (Kelvin)
402.65
Boiling point (Celsius)
599.00
Boiling point (Kelvin)
872.15
General information
Molecular weight
555.68g/mol
Molar mass
555.5040g/mol
Density
1.2568g/cm3
Appearence

Bedaquiline is a pale yellow solid. It is generally used in a crystalline form.

Comment on solubility

Solubility of N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine

N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine (C32H31BrN2O2S) exhibits intriguing solubility characteristics, which are influenced by its complex chemical structure. Understanding its solubility can be broken down into several key points:

  • Solvent Interaction: The compound's solubility is likely higher in organic solvents such as dimethyl sulfoxide (DMSO) or methanol due to its non-polar influences outweighing its polar functional groups.
  • Temperature Dependency: Like many organic compounds, its solubility may increase with temperature, making it crucial to assess this factor during experiments.
  • pH Sensitivity: The presence of amine groups may result in variable solubility in different pH environments; under acidic conditions, protonation of the amine may enhance aqueous solubility.
  • Potential Application: For pharmaceutical applications, understanding its solubility profile can be essential for formulation and bioavailability.

In conclusion, the solubility of C32H31BrN2O2S showcases the importance of considering various factors—such as solvent type, temperature, and pH. This can lead to a more profound understanding of its behavior in different environments. As the old saying goes, "like dissolves like," and this principle resonates well with the solubility of complex organic compounds like this one.

Interesting facts

Interesting Facts about N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine

N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine is a fascinating compound that integrates both nitrogen and sulfur elements into its structure, creating a unique framework suitable for diverse applications.

1. Chemical Structure

This compound features a complex bicyclic structure that combines a pyridine ring with a benzothiazine moiety. This fusion contributes significantly to its chemical properties and potential biological activities.

2. Potential Biological Activities

The distinct structural features of this compound suggest it may exhibit valuable biological properties, including:

  • Antimicrobial Activity: Compounds with similar structures have been researched for their potential to combat bacterial and fungal infections.
  • Antitumor Properties: The presence of specific nitrogen-containing rings often correlates with activity against various cancer cell lines.
  • Neuroprotective Effects: Some derivatives have indicated promising results in neuropharmacology, potentially aiding conditions like Alzheimer’s disease.

3. Synthesis and Derivatives

The synthesis of N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine can be intricate, involving multi-step reactions. Its derivatives are also of interest in medicinal chemistry, which may lead to:

  • Increased potency and specificity for certain biological targets.
  • Improved pharmacokinetic properties.

4. Research Significance

Ongoing research into this compound reflects the broader interest in:

  • Chemotherapeutic agents: The development of novel drugs targeting resistant pathogens.
  • Polycyclic compounds: Understanding their role in various chemical reactions and biological mechanisms.

Scientists continue to explore the intriguing properties of N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine, making it a significant subject of study in both chemistry and pharmacology.

Synonyms
Isothipendyl
Odantol
Udantol
482-15-5
Andanton
Isothipendylum
Isotipendilo
Actapront
Nilergex
Isothipendyl [INN:BAN]
Isothipendylum [INN-Latin]
Isotipendilo [INN-Spanish]
UNII-WVZ7K9P0JY
AY 56012
WVZ7K9P0JY
D 201
Dimethylaminoisopropylazaphenothiazine
EINECS 207-578-5
Actapront (TN)
BRN 0256817
Isothipendyl (INN)
ISOTHIPENDYL [MI]
ISOTHIPENDYL [INN]
N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine
AY-56012
(+/-)-ISOTHIPENDYL
ISOTHIPENDYL [WHO-DD]
Dimethyl-amino-isopropyl-thiophenyl-pyridyl-amin [German]
D-201
DTXSID5048267
Dimethyl-amino-isopropyl-thiophenyl-pyridyl-amin
EC 207-578-5
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-
4-27-00-07168 (Beilstein Handbook Reference)
10H-Pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine, N,N,alpha-trimethyl-
Andantol (TN)
N,N,alpha-Trimethyl-10H-pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine
10-(2-Dimethylaminopropyl)-1-Azaphenothiazine
10H-Pyrido[3,2-b][1,4]benzothiazine-10-ethanamine, N,N,.alpha.-trimethyl-
Isothipendylum (INN-Latin)
Isotipendilo (INN-Spanish)
N-DIMETHYLAMINOISOPROPYLTHIOPHENYLPYRIDYLAMINE
10-(2-Dimethylaminopropyl)-9-thia-1,10-diazaanthracene
AY 56012; D 201; Dimethylaminoisopropylazaphenothiazine
10-(2-Dimethylaminopropyl)-10H-pyrido[3,2-b][1,4]benzothiazine
10-(2-DIMETHYLAMINOPROPYL)-10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE
10H-Pyrido[3,2-b][1,4]benzothiazine, 10-[2-(dimethylamino)propyl]-
10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-ETHANAMINE, N,N,.ALPHA.-TRIMETHYL-
dimethyl(1-{9-thia-2,4-diazatricyclo[8.4.0.0^{3,8}]tetradeca-1(10),3,5,7,11,13-hexaen-2-yl}propan-2-yl)amine
isotipendile
dimethyl(1-(9-thia-2,4-diazatricyclo(8.4.0.0^(3,8))tetradeca-1(10),3,5,7,11,13-hexaen-2-yl)propan-2-yl)amine
Spectrum_001886
SpecPlus_000794
Spectrum5_001801
SCHEMBL29234
KBioSS_002416
DivK1c_006890
CHEMBL2111066
DTXCID0028242
KBio1_001834
KBio2_002410
KBio2_004978
KBio2_007546
D04AA22
R06AD09
CHEBI:135183
HY-A0178
AKOS015962142
DB08802
DA-64576
CS-0017519
NS00006563
D08091
Q928054
1-(10H-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl)-N,N-dimethylpropan-2-amine
10-(2-DIMETHYLAMINO-2-METHYLETHYL)-10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE
N,N-Dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)-2-propanamine #
207-578-5