Skip to main content

Nicotinamide diethylamide

ADVERTISEMENT
Identification
Molecular formula
C10H14N2O
CAS number
622-45-7
IUPAC name
N,N-diethylpyridine-3-carboxamide
State
State

At room temperature, nicotinamide diethylamide is a liquid.

Melting point (Celsius)
-24.00
Melting point (Kelvin)
249.20
Boiling point (Celsius)
247.50
Boiling point (Kelvin)
520.70
General information
Molecular weight
178.25g/mol
Molar mass
178.2470g/mol
Density
0.9960g/cm3
Appearence

Nicotinamide diethylamide is typically a colorless to pale yellow liquid. It has a characteristic, mildly amine-like odor.

Comment on solubility

Solubility of N,N-Diethylpyridine-3-carboxamide

N,N-Diethylpyridine-3-carboxamide (C10H14N2O) exhibits interesting solubility characteristics, reflecting its chemical structure and functional groups.

Generally, the solubility of organic compounds like N,N-diethylpyridine-3-carboxamide can be influenced by several factors:

  • Polarity: The presence of the amide group contributes to the overall polarity of the compound, potentially enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The amide functional group can form hydrogen bonds with water molecules, which can lead to increased solubility.
  • Hydrophobic Interactions: The diethyl groups, being hydrophobic, may limit solubility in highly polar solvents despite the presence of the polar amide group.

As a result, N,N-diethylpyridine-3-carboxamide is likely to be more soluble in organic solvents than in water. This unique combination of hydrophilic and hydrophobic properties leads to the conclusion that:

"Solubility is a complex interplay of molecular interactions."

In summary, while N,N-diethylpyridine-3-carboxamide shows some potential for solubility due to its polar characteristics, its overall solubility may be limited by the hydrophobic nature of the diethyl groups, making it less soluble in very polar environments.

Interesting facts

Interesting Facts About N,N-Diethylpyridine-3-carboxamide

N,N-Diethylpyridine-3-carboxamide, known for its versatile applications in organic chemistry, offers some intriguing insights for both researchers and students. This compound possesses a distinct pyridine ring, which contributes significantly to its chemical properties and reactivity.

Key Characteristics

  • Structure: The compound features a pyridine ring substituted at the 3-position, making it a valuable building block in synthetic chemistry.
  • Applications: Commonly utilized as a reagent, it plays a role in the synthesis of pharmaceuticals and agrochemicals.
  • Interactions: The diethylamino group enhances its solubility in organic solvents, promoting its usage in various chemical reactions.
  • Reactivity: Its ability to act as a base allows it to participate in numerous chemical transformations, making it a favorite among synthetic chemists.

Chemical Relevance

With its structural integrity, N,N-diethylpyridine-3-carboxamide stands out in the realm of organocatalysis. As noted by many chemists, “the unique properties of the pyridine nucleus can lead to unprecedented reactivity.” This means that molecules like this one can potentially open new pathways for innovative synthesis. 

Conclusion

In summary, N,N-diethylpyridine-3-carboxamide is not just a compound of academic interest; it serves as a vital player in the synthesis landscape. As research advances, the potential for discovering new reactions and applications continues to grow. Whether you are a budding chemist or an experienced scientist, delving into the world of this compound can certainly enhance your understanding of aromatic compounds and their significance in chemical synthesis.

Synonyms
Nikethamide
N,N-DIETHYLNICOTINAMIDE
59-26-7
Coramine
Nicethamide
Nikethyl
Anacardone
3-Pyridinecarboxamide, N,N-diethyl-
Nicetamide
Niquetamida
Corvin
Anacordone
Carbamidal
Cardiagen
Cardiamina
Coraetamidum
Coraethamide
Coralept
Coravita
Cordiamid
Cordiamine
Corditon
Corespin
Corethamide
Corotonin
Corvotone
Dynamicarde
Kardonyl
Nicamide
Nicordamin
Nicorine
Niketamid
Niketilamid
Procorman
Pyricardyl
Salvacorin
Stiminol
Corivo
Corovit
Corywas
Niamine
Nicoryl
Tonocor
Nicotinic acid diethylamide
Camphozone
Canfodiamina
Cardiamide
Cardiamine
Coraethamidum
Niketamide
Niketharol
Nisetamide
Procardine
Stellamine
Ventramine
Astrocar
Cardamine
Cardiamid
Cardimon
Citocor
Coracon
Corazone
Cordiamin
Cordynil
Corediol
Coretone
Cormotyl
Cornotone
Corvitan
Corvitol
Danamine
Dinacoryl
Dynacoryl
Elitone
Eucoran
Hansacor
Inicardio
Kardiamid
Kordiamin
Leptamin
Mediamid
Nikardin
Nikorin
Percoral
Reformin
Rehormin
Salvacard
Sancora
Solyacord
Stimulin
Cormed
Cormid
Diethylnicotinamide
Diethyl-Nicotamide
Diaethyl-nicotinamid
Nicaethamidum
Nicethamidum
N,N-diethylpyridine-3-carboxamide
Nicor
beta-Pyrimidum
Dietilamide-Carbopiridina
Nicetamide [DCIT]
Carditonic
Nicetamida
Pyridine-3-carboxydiethylamide
Ni-Cor
Nicetamida [INN-Spanish]
Nicethamidum [INN-Latin]
Diaethyl-nicotinamid [German]
Diaethylamidum acidi nicotinici
Diethylamid kyseliny nikotinove
Niketamine
Vasazol
Pyridine-3-carboxylic acid diethylamide
N,N-Diethyl-3-pyridinecarboxamide
.beta.-Pyrimidum
Carditonic (TN)
EINECS 200-418-5
Nicotinamide, N,N-diethyl-
MFCD00006386
Nikethamide [INN:BAN:NF]
Nikethamide (INN)
NSC 130820
NSC-130820
Diethylamid kyseliny nikotinove [Czech]
BRN 0005743
DTXSID9046524
AI3-01438
368IVD6M32
NIKETHAMIDE [MI]
NIKETHAMIDE [INN]
NIKETHAMIDE [MART.]
NIKETHAMIDE [WHO-DD]
DTXCID7026524
3-(N,N-Diethylcarbamoyl)pyridine
NIKETHAMIDE [EP MONOGRAPH]
NCGC00166026-01
Nicotinamide,N-diethyl-
Nicetamida (INN-Spanish)
Nicethamidum (INN-Latin)
NIKETHAMIDE (MART.)
WLN: T6NJ CVN2&2
3-Pyridinecarboxamide,N-diethyl-
Corethamid
Nizethamid
Coramin
NIKETHAMIDE (EP MONOGRAPH)
Diethylnicotinamid
N,N-Diethylnicotinamide (Nikethamide)
Nicotinic Diethylamide
Nickethamide
Ecoran
UNII-368IVD6M32
Coractiv N
BETAPYRIMIDUM
NICETHAMID
NIKETHAMIDUM
NIQUETAMIDE
SALVACORD
VASOZOL
Diethylamide, Nicotinic
Nikethamide (Standard)
N,N-diethyl nicotinamide
MLS004773905
SCHEMBL246456
N,N-DIETHYLNICOTINOAMIDE
N,N-Diethylnicotinamide, 99%
CHEMBL2104607
CORAMINE (PHARMACEUTICAL)
HY-B1280R
R07AB02
CHEBI:134814
HMS3264D18
HMS3886G05
Pharmakon1600-01506157
HY-B1280
NICOTINIC ACID DIETHYL AMIDE
Tox21_112295
BDBM50248014
NSC-62103
NSC760377
s4887
AKOS003607578
CCG-213619
CS-8003
DB13655
FD31942
MB00187
NSC-169863
NSC-760377
CAS-59-26-7
NCGC00166026-02
AC-12043
AC-31724
AS-48195
SMR000059067
DB-053354
D0514
NS00008862
D07408
F19704
AB01563149_01
EN300-6492955
Q902548
SR-01000939653
SR-01000939653-2
BRD-K91544578-001-03-8
Z31723199
Nikethamide, European Pharmacopoeia (EP) Reference Standard
200-418-5