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Etizolam

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Identification
Molecular formula
C17H15ClN4S
CAS number
40054-69-1
IUPAC name
N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
State
State

Etizolam is typically found as a solid at room temperature. This is due to its nature as a pharmaceutical compound where it is often prepared for dosage in tablet or pill form. Its state as a solid facilitates easy dosage and administration.

Melting point (Celsius)
147.50
Melting point (Kelvin)
420.65
Boiling point (Celsius)
245.00
Boiling point (Kelvin)
518.15
General information
Molecular weight
342.84g/mol
Molar mass
342.0790g/mol
Density
1.3090g/cm3
Appearence

Etizolam is a white to off-white crystalline powder. It may appear as fine granules depending on the manner of synthesis and processing.

Comment on solubility

Solubility of N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, with the formula C17H15ClN4S, exhibits some interesting characteristics when it comes to solubility.

The solubility of this compound can be influenced by various factors:

  • Polarity: The presence of functional groups profoundly affects its interaction with solvents. For instance, the nitrogen atoms in the triazole and pyrimidine rings can enhance polarity.
  • Solvent Choice: In general, this compound is expected to be more soluble in polar organic solvents such as methanol, ethanol, and DMSO, while showing limited solubility in non-polar solvents.
  • Temperature Dependency: Like many organic compounds, solubility may increase with temperature, suggesting that heating can be a useful method to enhance dissolution.

It is worth noting that the specific solubility of N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine has not been widely documented in the literature. Hence, experimental evaluation in various solvents would be valuable for practical applications. Understanding the solubility characteristics of this compound is crucial in the context of its potential use in pharmaceutical formulations and biochemical studies.

In summary:

  • Expected to be soluble in polar organic solvents.
  • Limited solubility in non-polar solvents.
  • Temperature can enhance solubility.
Interesting facts

Interesting Facts about N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine is a fascinating compound with diverse implications in the field of chemistry and pharmacology. Here are some intriguing aspects:

  • Pharmaceutical Potential: This compound belongs to a class of triazolo-pyrimidines, known for their potent biological activities. It has garnered interest in drug development, particularly in the search for novel therapeutic agents.
  • Chemical Structure: The structural framework of this compound includes a triazole and pyrimidine functionality. This unique combination often leads to enhanced activities, making it worthwhile for detailed investigation.
  • Synthetic Routes: The synthesis of N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine can offer valuable insights into reaction mechanisms and the development of new synthetic methodologies that harness the triazole ring system.
  • Research Applications: Researchers explore compounds like this for their potential as antioxidants, anti-inflammatory, or anti-cancer agents. This highlights the critical intersection between chemistry and medicinal applications.
  • Structure-Activity Relationship (SAR): In studying this compound, scientists often investigate how modifications to its structure affect biological activity, contributing to the broader understanding of drug design.

In summary, N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine is not only an intriguing chemical entity due to its structural characteristics, but also a pivotal compound in ongoing research concerning potential therapeutic applications. As students and scientists delve deeper into its properties, they continually unearth new possibilities and insights.

Synonyms
trapidil
15421-84-8
Rocornal
Trapymin
Avantrin
Trapymine
N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
AR 12008
Trapidilum
Trapidilum [INN-Latin]
AR-12008
(1,2,4)Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl-
EINECS 239-434-2
Trapidil [INN:BAN:JAN]
Rocornal (TN)
BRN 0186842
EYG5Y6355E
DTXSID0045416
7-Diethylamino-5-methyl-s-triazolo(1,5-a)pyrimidine
TRAPIDIL [INN]
TRAPIDIL [JAN]
TRAPIDIL [MI]
MFCD00193104
TRAPIDIL [MART.]
TRAPIDIL [WHO-DD]
N,N-Diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidine-7-amine
5-Methyl-7-diethylamino-s-triazolo-(1,5-a)-pyrimidine
MLS000567667
TRAPIDIL [EP MONOGRAPH]
s-Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-
DTXCID8025416
5-Methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin [German]
5-Methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin
NCGC00016715-01
SMR000154170
Trapidilum (INN-Latin)
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, N,N-diethyl-5-methyl-
CAS-15421-84-8
TRAPIDIL (MART.)
5-Methyl-7-diethylamino-S-triazolo(1,5-a)pyrimidine
TRAPIDIL (EP MONOGRAPH)
5-Methyl-7-(diethylamino)-s-triazolo[1,5-a]pyrimidine
7-(Diethylamino)-5-methyl-2-triazolo[1,5-a]pyrimidine
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO(1,5-A)PYRIMIDINE.
5-Methyl-7-(diethylamino)-s-triazolo(1,5-a)pyrimidine
7-(Diethylamino)-5-methyl-2-triazolo(1,5-a)pyrimidine
7-Diethylamino-5-methyl(1,2,4)triazolo(1,5-a)pyrimidine
7-Diethylamino-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine
UNII-EYG5Y6355E
N,N-diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidin-7-amine
Trapidil,(S)
Trapidil (Standard)
Opera_ID_461
Prestwick0_001012
Prestwick1_001012
Prestwick2_001012
Prestwick3_001012
Trapidil (JP17/INN)
SCHEMBL33563
BSPBio_001163
MLS000881142
SPBio_003034
BPBio1_001281
CHEMBL132767
Trapidil, >=98% (HPLC)
7-(Diethylamino)-5-methyl-s-triazolo(1,5-a)pyrimidine
CHEBI:32254
HY-B1016R
C01DX11
GLXC-03673
HMS1571K05
HMS1735K19
HMS2098K05
HMS2231G07
HMS3372J09
HMS3715K05
BCP09350
HY-B1016
N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
Tox21_110578
s4736
AKOS001093408
Tox21_110578_1
CCG-221012
CS-4529
DB09283
HS-0048
NCGC00016715-02
NCGC00016715-03
NCGC00016715-04
AC-32565
FD153326
AB00457635
NS00005195
D01220
EN300-227431
F31376
AB00457635-12
SR-01000673280
Q2449982
SR-01000673280-3
BRD-K95763993-001-03-7
BRD-K95763993-001-19-3
Z56791867
Trapidil, European Pharmacopoeia (EP) Reference Standard
N,N-Diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine #
239-434-2