Skip to main content

N,N'-bis(4-ethoxyphenyl)acetamidine

ADVERTISEMENT
Identification
Molecular formula
C18H22N2O2
CAS number
1822-51-9
IUPAC name
N,N'-bis(4-ethoxyphenyl)acetamidine
State
State

At room temperature, N,N'-bis(4-ethoxyphenyl)acetamidine is typically a solid. Its solid state makes it easy to handle in laboratory conditions, though care should be taken to store it appropriately to avoid degradation.

Melting point (Celsius)
132.00
Melting point (Kelvin)
405.00
Boiling point (Celsius)
332.00
Boiling point (Kelvin)
605.00
General information
Molecular weight
312.40g/mol
Molar mass
312.4030g/mol
Density
1.1137g/cm3
Appearence

N,N'-bis(4-ethoxyphenyl)acetamidine is typically encountered as a solid compound. It has a crystalline appearance, often white to off-white in color. The crystalline nature of the compound can vary depending on the purity and form of crystallization used during its synthesis.

Comment on solubility

Solubility Overview of N,N'-bis(4-ethoxyphenyl)acetamidine

N,N'-bis(4-ethoxyphenyl)acetamidine, known for its intriguing properties, reveals some interesting aspects regarding its solubility.

Typically, the solubility of organic compounds like N,N'-bis(4-ethoxyphenyl)acetamidine can be influenced by several factors:

  • Polarity: The presence of ethoxy groups enhances its ability to interact with polar solvents, which often leads to better solubility in such media.
  • Solvent Type: It tends to dissolve more readily in organic solvents like ethanol and acetone, while exhibiting limited solubility in water.
  • Temperature Effects: Generally, solubility increases with temperature, indicating that higher temperatures may facilitate greater dissolution in suitable solvents.

However, it's essential to note that not all organic compounds exhibit high solubility in water, and this compound appears to be no exception. For practical applications, experimenting with different solvent systems may yield optimal solubility results.

In summary, understanding the solubility profile of N,N'-bis(4-ethoxyphenyl)acetamidine is crucial for its applications, and it is advised to consider different solvents to maximize its solubility potential.

Interesting facts

Interesting Facts about N,N'-bis(4-ethoxyphenyl)acetamidine

N,N'-bis(4-ethoxyphenyl)acetamidine is a fascinating compound belonging to the class of amidines. Amidines are known for their unique properties and applications. Here are some intriguing aspects of this particular compound:

  • Structural Diversity: The compound features two ethoxyphenyl groups attached to an acetamidine backbone. This structural design enhances its potential reactivity and interaction with biological systems.
  • Pharmaceutical Potential: Compounds like N,N'-bis(4-ethoxyphenyl)acetamidine have gained attention in medicinal chemistry due to their potential use as pharmaceuticals, especially in areas targeting infectious diseases.
  • Building Block for Synthesis: This amidine can serve as a key building block for the synthesis of more complex compounds, potentially leading to the development of novel materials or therapeutic agents.
  • Reactivity: The amidine functional group is known for exhibiting basic properties and can act as a nucleophile, making it versatile in various chemical reactions.
  • Biological Involvement: Compounds with a similar structure may interact with biological molecules, opening avenues for research in drug design and enzyme inhibition.

In summary, N,N'-bis(4-ethoxyphenyl)acetamidine exemplifies the exciting intersection of organic synthesis and pharmacology. Its structural features and potential applications make it a compound of interest for researchers seeking to explore the vast possibilities within the realm of chemistry.

Synonyms
Phenacaine
Fenacaine
Holocaine
Tanicaine
101-93-9
N,N'-Bis(4-ethoxyphenyl)ethanimidamide
Phenacaine [INN]
Fenacaina
N,N'-Bis(p-ethoxyphenyl)acetamidine
Phenacainum
Fenacaina [INN-Spanish]
Phenacainum [INN-Latin]
Halocaine
HOLOCALIN(P)
ACETAMIDINE, N,N'-BIS(p-ETHOXYPHENYL)-
N',N(sup 2)-Bis(p-ethoxyphenyl)acetamidine
UNII-V3M4D317W8
Fenacaine; Holocaine
BRN 2702842
Ethanimidamide, N,N'-bis(4-ethoxyphenyl)-
V3M4D317W8
PHENACAINE [WHO-DD]
DTXSID0046062
4-13-00-01108 (Beilstein Handbook Reference)
Fenacaina (INN-Spanish)
Phenacainum (INN-Latin)
ETHANIMIDAMIDE, N,N'-BIS(4-ETHOXYPHENOL)-
N(SUP 1),N(SUP 2)-BIS(P-ETHOXYPHENYL)ACETAMIDINE
NCGC00181080-01
SCHEMBL24365
SCHEMBL82180
MLS006011717
CHEMBL127123
SCHEMBL16070026
CHEBI:135260
HY-B1726
BDBM50225485
DA-74251
N,N'-Bis-(4-ethoxy-phenyl)-acetamidine
SMR004703439
1ST165445
CS-0013731
NS00005484
Ethanimidamide, N,N'-bis(4-ethoxyphenyl)-(9CI)
Q7181308
aniline, 4-ethoxy-N-(1-(p-ethoxyphenylimino)ethyl)-
BRD-K81092066-311-01-6