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Niacin

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Identification
Molecular formula
C6H5NO2
CAS number
59-67-6
IUPAC name
nicotinic acid
State
State

Niacin is typically found in a solid state at room temperature.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.00
Boiling point (Celsius)
237.00
Boiling point (Kelvin)
510.00
General information
Molecular weight
123.11g/mol
Molar mass
123.1110g/mol
Density
1.4730g/cm3
Appearence

Niacin, also known as nicotinic acid, appears as a white to slightly yellow crystalline solid. It may be available in powder form and is typically odorless.

Comment on solubility

Solubility of Nicotinic Acid (C6H5NO2)

Nicotinic acid, also known as niacin or vitamin B3, displays interesting solubility characteristics that enhance its bioavailability and utility in various applications. It is primarily characterized by the following solubility properties:

  • Solubility in Water: Nicotinic acid is highly soluble in water, with solubility values reported around 1 g in 1.5 mL of water at room temperature. This substantial solubility arises from its polar carboxylic acid group, which facilitates hydrogen bonding with water molecules.
  • Solvent Interaction: It is also soluble in various organic solvents such as ethanol and methanol. This characteristic allows for its incorporation into numerous pharmaceutical formulations and dietary supplements.
  • Effect of pH: The solubility of nicotinic acid can be affected by pH, as it can exist in both protonated and deprotonated forms. In acidic conditions, it remains protonated, while in neutral to alkaline conditions, it can form an anion, which generally enhances its solubility.

In conclusion, the solubility of nicotinic acid is a vital factor influencing its functionality and is characterized by:

  1. High water solubility, making it easily absorbable in biological systems.
  2. Compatibility with organic solvents, expanding its usage in various chemical processes.
  3. pH-dependent behavior, providing versatility under different conditions.

Understanding these solubility traits of nicotinic acid is essential for optimizing its applications in health and medicine.

Interesting facts

Interesting Facts about Nicotinic Acid

Nicotinic acid, also known as niacin or vitamin B3, is a vital compound that plays a crucial role in human health. Here are some fascinating aspects of nicotinic acid:

  • Essential Nutrient: Nicotinic acid is one of the B vitamins necessary for maintaining proper bodily functions. It aids in the conversion of food into cellular energy.
  • Cholesterol Management: It is recognized for its ability to help manage cholesterol levels, by lowering LDL (bad cholesterol) and boosting HDL (good cholesterol).
  • Metabolic Role: Nicotinic acid contributes to over 200 enzymatic reactions, primarily by serving as a precursor for NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which are critical for metabolism.
  • Deficiency Effects: A deficiency in nicotinic acid can lead to the disease known as pellagra, characterized by symptoms such as dermatitis, diarrhea, and dementia.
  • Sources: This compound can be found in various food sources, including meat, fish, whole grains, and legumes, making it relatively easy to incorporate into the diet.

As a versatile compound, nicotinic acid is essential not only for biological processes but also has therapeutic applications. It is often used in formulations aimed at improving cardiovascular health and can serve as a treatment for certain conditions like hyperlipidemia.

Considering its numerous benefits, it is often referred to as a super vitamin that is foundational in maintaining our health.

Synonyms
nicotinic acid
niacin
59-67-6
Pyridine-3-carboxylic acid
3-pyridinecarboxylic acid
3-Carboxypyridine
wampocap
vitamin B3
Niaspan
Acidum nicotinicum
nicolar
Apelagrin
Pellagrin
Akotin
Daskil
Efacin
Pelonin
Linic
nicamin
nicobid
nicocap
Enduracin
Nicodelmine
Niconacid
Nicotinipca
Pellagramin
Direktan
Nicacid
Nicangin
Peviton
Bionic
Diacin
Nicyl
Nyclin
Niac
Vitaplex N
Davitamon PP
Nico-Span
Tega-Span
Nicocidin
Nicocrisina
Niconazid
Nicotamin
Nicotene
Nicovasan
Nicovasen
Nipellen
SK-Niacin
Naotin
Niacor
Nicodon
Niconat
Nicosan 3
Nicosyl
Nicotil
Tinic
3-Carboxylpyridine
Nicotine acid
nicotinate
Nicoside
Slo-niacin
Acide nicotinique
NICO
3-Picolinic acid
Nicotinsaure
Nico-400
Pyridine-beta-carboxylic acid
Nicagin
anti-Pellagra vitamin
Acido nicotinico
Caswell No. 598
PP Factor
Kyselina nikotinova
P.P. factor
Pellagra preventive factor
S115
Nicotinsaure [German]
3-Pyridylcarboxylic acid
m-Pyridinecarboxylic acid
MFCD00006391
Kyselina nikotinova [Czech]
niacine
CCRIS 1902
Pyridine-carboxylique-3
EPA Pesticide Chemical Code 056701
Acide nicotinique [INN-French]
Acido nicotinico [INN-Spanish]
Acidum nicotinicum [INN-Latin]
HSDB 3134
Pyridine-carboxylique-3 [French]
AI3-18994
Pyridinecarboxylic acid, 3-
Niacin [USP]
SR 4390
BRN 0109591
Niacin extended release
Nicotinic acid [INN]
NAH
CHEMBL573
beta-pyridinecarboxylic acid
NSC-169454
MLS000069603
Pyridine-.beta.-carboxylic acid
DTXSID1020932
CHEBI:15940
Niacin (USP)
2679MF687A
P.P. factor-pellagra preventive factor
CAS-59-67-6
pyridine, 3-carboxy-
NCGC00016268-02
SMR000059024
[5, 6-3H]-niacin
DTXCID10932
Niacin [USAN]
Nicotinicacid
NIO
Niacin (nicotinic acid)
SR-01000722017
EINECS 200-441-0
NIASPAN TITRATION STARTER PACK
NSC 169454
pellagra
Nikotinsaeure
Nicotinic Acid;
UNII-2679MF687A
preventative factor
antipellagra vitamin
Niaspan (TN)
3-Pyridylcarboxylate
3PyrCOOH
[3H]nicotinic acid
Niacor (TN)
Nicotinic Acid,(S)
[3H]-Nicotinic acid
Spectrum_001063
pyridinium-3-carboxylate
NIACIN [VANDF]
NIACIN [HSDB]
Nicotinic acid (Niacin)
5-pyridinecarboxylic acid
NIACIN [FCC]
NIACIN [USP-RS]
Opera_ID_1346
Prestwick0_000881
Prestwick1_000881
Prestwick2_000881
Prestwick3_000881
Pyridine-3-carbonic acid
Spectrum2_000006
Spectrum3_000515
Spectrum4_000965
Spectrum5_001287
VITAMIN B-3
3-Pyridyl carboxylic acid
Nicotinic acid-13C1 )
Nicotinic acid-d3(major)
WLN: T6NJ CVQ
3-pyridine carboxylic acid
bmse000104
Nicotinic acid, >=98%
Nicotinic acid, USP grade
EC 200-441-0
SCHEMBL1433
NICOTINIC ACID [MI]
Oprea1_514398
VITAMIN B3 [VANDF]
BSPBio_000662
BSPBio_002069
KBioGR_001309
KBioSS_001543
NIACIN [ORANGE BOOK]
NICOTINIC ACID [JAN]
5-22-02-00057 (Beilstein Handbook Reference)
Nicotinic acid (Vitamin B3)
BIDD:GT0644
DivK1c_000695
Nicotinic acid (JP18/INN)
SIMCOR COMPONENT NIACIN
SPECTRUM1500430
.beta.-Pyridinecarboxylic acid
SPBio_000011
SPBio_002881
ADVICOR COMPONENT NIACIN
NIACIN [USP MONOGRAPH]
NICOTINIC ACID [VANDF]
BPBio1_000730
GTPL1588
GTPL1594
NICOTINIC ACID [MART.]
NICOTINIC ACID [WHO-DD]
NICOTINIC ACID [WHO-IP]
BDBM23515
HMS502C17
KBio1_000695
KBio2_001543
KBio2_004111
KBio2_006679
KBio3_001569
ABT-919
NICOTINIC ACID [EMA EPAR]
NINDS_000695
HMS1570B04
HMS1920P17
HMS2091H22
HMS2097B04
HMS2236A05
HMS3259K21
HMS3371E07
HMS3655K08
HMS3714B04
Pharmakon1600-01500430
Nicotinic acid, analytical standard
BCP16301
HCA98714
HY-B0143
STR00112
Tox21_110337
Tox21_201420
Tox21_302904
AC8691
BBL037343
CCG-38340
NICOTINIC ACID [EP IMPURITY]
Nicotinic acid, for synthesis, 99%
NSC169454
NSC757241
s1744
STK301803
NICOTINIC ACID [EP MONOGRAPH]
AKOS000118980
Nicotinic acid, >=99.5% (HPLC)
Tox21_110337_1
CS-1946
DB00627
FN16182
NC00524
Nicotinic Acid 1.0 mg/ml in Methanol
NSC-757241
PS-4255
SDCCGMLS-0066610.P001
IDI1_000695
NCGC00016268-01
NCGC00016268-03
NCGC00016268-04
NCGC00016268-05
NCGC00016268-08
NCGC00016268-09
NCGC00016268-13
NCGC00094734-01
NCGC00094734-02
NCGC00256537-01
NCGC00258971-01
AC-22484
ACIDUM NICOTINICUM [WHO-IP LATIN]
BP-21419
NCI60_001041
Nicotinic acid, plant cell culture tested
SY011111
SBI-0051456.P003
DB-007765
Nicotinic Acid [Matrix for MALDI-TOF/MS]
AB00052050
N0082
N1103
Nicotinic acid 10 microg/mL in Acetonitrile
Nicotinic acid, purum, >=99.0% (HPLC)
NS00003500
SW197229-3
EN300-16693
C00253
D00049
Nicotinic acid, SAJ special grade, >=99.5%
AB00052050-13
AB00052050_14
AB00052050_15
Nicotinic acid, meets USP testing specifications
AC-907/25014105
AE-641/00368010
L001199
METHYL NICOTINATE IMPURITY A [EP IMPURITY]
Q134658
SR-01000722017-2
SR-01000722017-3
SR-01000722017-4
BRD-K60237333-001-26-3
BRD-K60237333-001-27-1
BRD-K60237333-001-28-9
Pyridine-3-carboxylic acid;Vitamin B3;Nicotinic acid
Z56755709
3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E
F2191-0082
Niacin, United States Pharmacopeia (USP) Reference Standard
Nicotinic acid, certified reference material, TraceCERT(R)
Nicotinic acid, European Pharmacopoeia (EP) Reference Standard
Nicotinic acid, matrix substance for MALDI-MS, >=99.5% (HPLC)
InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9
Nicotinic acid, for inorganic trace analysis, >=99.999% (metals basis)
Niacin (Nicotinic Acid), Pharmaceutical Secondary Standard; Certified Reference Material
101113-41-1
Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, >=98%