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Abacavir

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Identification
Molecular formula
C14H18ClN5O
CAS number
188062-50-2
IUPAC name
N6-(3-chlorophenyl)-N2-(1-ethyl-2-methyl-propyl)-9-isopropyl-purine-2,6-diamine
State
State

Abacavir is usually a solid at room temperature. It is stable under normal laboratory conditions and does not readily change its state without external intervention such as heat application or reaction with other chemicals.

Melting point (Celsius)
168.50
Melting point (Kelvin)
441.60
Boiling point (Celsius)
390.80
Boiling point (Kelvin)
664.00
General information
Molecular weight
286.77g/mol
Molar mass
286.3320g/mol
Density
1.4000g/cm3
Appearence

Abacavir typically appears as a white to off-white crystalline solid. It is odorless and tasteless, with crystalline properties that can be observed under polarized light. The crystals are often fine and can be powdery in appearance.

Comment on solubility

Solubility of N6-(3-chlorophenyl)-N2-(1-ethyl-2-methyl-propyl)-9-isopropyl-purine-2,6-diamine

The solubility of the compound N6-(3-chlorophenyl)-N2-(1-ethyl-2-methyl-propyl)-9-isopropyl-purine-2,6-diamine, represented by the chemical formula C14H18ClN5O, is a subject of interest for both researchers and formulators. Understanding the solubility characteristics of this compound can provide insights into its functionality and potential applications.

Key Points on Solubility:

  • Polar vs. Non-Polar Solvents: The presence of a chlorine atom and several nitrogen atoms hints at potential polar characteristics, suggesting that this compound may be more soluble in polar solvents like water or alcohols.
  • Organic Solubility: Due to its complex organic structure with multiple alkyl groups, the compound may exhibit moderate solubility in organic solvents such as DMSO and methanol.
  • Influence of Functional Groups: The functional groups present can significantly affect solubility; for instance, the presence of amine groups typically enhances water solubility.
  • Temperature Dependence: Solubility can also be temperature-dependent, with many compounds exhibiting increased solubility at higher temperatures.

In summary, while the precise solubility of N6-(3-chlorophenyl)-N2-(1-ethyl-2-methyl-propyl)-9-isopropyl-purine-2,6-diamine may vary according to the solvent choice and temperature, the considerations above provide a fundamental framework to predict its behavior in various environments. Further experimental data is essential for accurate solubility assessments.

Interesting facts

Interesting Facts about N6-(3-chlorophenyl)-N2-(1-ethyl-2-methyl-propyl)-9-isopropyl-purine-2,6-diamine

This complex compound, often associated with the fascinating world of purines, showcases a unique structure that is of significant interest in medicinal chemistry. Here are some intriguing aspects:

  • Medicinal Prominence: Compounds in the purine class, like this one, frequently serve as vital building blocks in pharmaceutical research, particularly in the development of drugs targeting cancer and viral infections.
  • Structure-Activity Relationship (SAR): The varied substituents on the purine base highlight the concept of SAR. Each modification in the compound’s structure can drastically influence its biological activity and therapeutic potential.
  • As a Chlorinated Compound: The presence of a chlorine atom in this structure often enhances lipophilicity, allowing better membrane penetration and often impacting the bioavailability of the compound in clinical applications.
  • Synthetic Versatility: The synthesis of such complex molecules often involves elaborate multi-step organic reactions, showcasing the creativity and precision required in modern organic synthesis.
  • Role in Biochemistry: Purines are fundamental components of nucleotides and nucleic acids, serving essential roles in energy transfer (ATP) and cellular signaling (cAMP), thus reinforcing the foundational importance of compounds like ours in biochemistry.

In summary, N6-(3-chlorophenyl)-N2-(1-ethyl-2-methyl-propyl)-9-isopropyl-purine-2,6-diamine is not just a molecule; it is a gateway into a vast field of research that intertwines chemistry, biology, and medicine. Engaging with this compound allows scientists to explore the intricate ways that molecular structure can affect biological function, leading to novel therapeutic strategies.