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Primaquine phosphate

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Identification
Molecular formula
C15H21N3O · H3PO4
CAS number
63-45-6 (Primaquine)
144-41-2 (Phosphate)
IUPAC name
N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid
State
State

In its base form, primaquine phosphate is usually found as a solid crystalline powder. It is stable under standard temperature and pressure conditions, making it suitable for pharmaceutical uses in tablet forms. It is typically dissolved in water for use in medicinal applications.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
276.00
Boiling point (Kelvin)
549.15
General information
Molecular weight
455.43g/mol
Molar mass
456.3720g/mol
Density
1.2700g/cm3
Appearence

Primaquine phosphate appears as a white to off-white crystalline powder. It is typically odorless and can be hygroscopic, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid

The solubility of the compound N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid, represented by the formula C15H21N3O · H3PO4, can be intriguing due to its unique composition and the presence of the phosphoric acid moiety. Here’s a closer look at its solubility characteristics:

  • Solvent Compatibility: This compound is likely to exhibit good solubility in polar solvents, particularly water, due to the presence of the phosphate group, which can interact favorably with water molecules through hydrogen bonding.
  • Temperature Influence: As with many chemical compounds, increased temperatures can enhance solubility, so it may dissolve better at higher temperatures compared to lower ones.
  • pH Effect: The acidic nature of the phosphoric acid may suggest that the solubility could also be affected by the pH of the solution. In more acidic conditions, the solubility might increase due to increased ionization.
  • Concentration Limits: It’s essential to consider saturation limits; at high concentrations, the compound may reach a point where no more can dissolve, leading to precipitation.

In summary, the solubility of N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid is influenced by various factors like solvent type, temperature, and pH. Understanding these parameters is critical for applications and further research involving this compound.

Interesting facts

Interesting Facts about N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid

N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid is a unique compound that combines a distinctive quinoline ring with a linear pentamine chain, offering intriguing insights into its potential applications and chemical behavior.

Key Features:

  • Quinoline Structure: The quinoline moiety enhances the compound's ability to interact with biological systems, making it a candidate for pharmaceutical research.
  • Amine Functionalities: The presence of two amine groups in the structure suggests the ability to engage in hydrogen bonding, which is critical in forming complexes and enhancing solubility.
  • Phosphate Partner: The interaction with phosphoric acid can improve the compound's stability and solubility, which is essential for its usability in various applications.

This compound can be explored for its potential as a therapeutic agent. The quinoline derivatives are often known for their biological activities, including:

  • Antimicrobial properties
  • Anti-inflammatory effects
  • Anticancer activities

As noted by researchers, “the modification of pharmacophores unveils a plethora of possibilities” in drug design. Thus, compounds like N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid may pave the way for developing new treatment strategies against various diseases. The fusion of a quinoline segment with an amine and phosphate will likely enhance the compound's specificity and efficacy.

In summary, N4-(6-methoxy-8-quinolyl)pentane-1,4-diamine;phosphoric acid represents a fascinating intersection of organic chemistry and medicinal applications, making it a compelling subject for further study.

Synonyms
primaquine diphosphate
63-45-6
PRIMAQUINE PHOSPHATE
Primaquine bisphosphate
Malquine
Primaquine (Diphosphate)
1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
CCRIS 1946
EINECS 200-560-8
NSC 149765
UNII-H0982HF78B
CAMDEN
DTXSID6045248
H0982HF78B
NSC-149765
Primaquine phosphate [USP]
Primaquine phosphate;Primaquine bisphosphate
DTXCID4025248
N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine bis(phosphate)
N-(5-aminopentan-2-yl)-6-methoxyquinolin-8-amine; bis(phosphoric acid)
8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate
Primaquine phosphate (USP)
WR 2975
4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid
Primaquine Diphosphate (>90%)
Primaquine bis(phosphate)
PRIMAQUINE PHOSPHATE (MART.)
PRIMAQUINE PHOSPHATE [MART.]
PRIMAQUINE PHOSPHATE (USP-RS)
PRIMAQUINE PHOSPHATE [USP-RS]
QUINOLINE, 8-((4-AMINO-1-METHYLBUTYL)AMINO)-6-METHOXY-, DIPHOSPHATE
PRIMAQUINE PHOSPHATE (USP MONOGRAPH)
PRIMAQUINE PHOSPHATE [USP MONOGRAPH]
PRIMAQUINE DIPHOSPHATE (EP MONOGRAPH)
PRIMAQUINE DIPHOSPHATE [EP MONOGRAPH]
SR-05000001864
NCGC00178754-06
Diphosphate, Primaquine
Primaquine (TN)
Prestwick_406
Primaquini diphosphas
MFCD00013166
Phosphate, Primaquine
SN13272 diphosphate
8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline diphosphate
CAS-63-45-6
NCGC00016284-01
8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline phosphate (1:2)
PRIMACHINE PHOSPHATE
SCHEMBL41096
CHEMBL43128
Primaquine bisphosphate, 98%
SPECTRUM1500500
HMS502I08
Primaquine phosphate (JAN/USP)
CHEBI:232993
HMS1569O14
HMS1920J18
HMS2092A19
HMS2096O14
HMS3652B19
HMS3713O14
PRIMAQUINE PHOSPHATE [JAN]
PRIMAQUINE DIPHOSPHATE [MI]
IBSCREEN-BB BB_SC-03079
Primaquine (diphosphate) (Standard)
PRIMAQUINE PHOSPHATE [VANDF]
Tox21_110350
CCG-40283
HY-12651R
s4237
PRIMAQUINE PHOSPHATE [WHO-DD]
(+-)-8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline phosphate (1:2)
1,4-Pentanediamine, N(sup 4)-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
AKOS026749962
Quinoline, 8-((4-amino-1-methylbutyl)amino)-6-methoxy-, phosphate (1:2)
Tox21_110350_1
CS-3875
FP27162
PRIMAQUINE DIPHOSPHATE [WHO-IP]
1,4-Pentanediamine, N(sup 4)-(6-methoxy-8-quinolinyl)-, (+-)-, phosphate (1:2)
NCGC00094767-01
NCGC00094767-02
AS-13148
HY-12651
PRIMAQUINE PHOSPHATE [ORANGE BOOK]
DB-054488
NS00078842
PRIMAQUINI DIPHOSPHAS [WHO-IP LATIN]
SW196647-3
D02126
E75742
EN300-119547
SR-05000001864-1
SR-05000001864-3
SR-05000001864-7
Q27279400
N4-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine Phosphate
N4-(6-methoxyquinolin-8-yl)pentane-1,4-diaminebis(phosphate)
(4RS)-N4-(6-Methoxyquinolin-8-yl)pentane-1,4-diamine diphosphate
8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate salt
1,4-Pentanediamine, N^4-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
Primaquine diphosphate, European Pharmacopoeia (EP) Reference Standard
Primaquine phosphate, United States Pharmacopeia (USP) Reference Standard
N4-(6-METHOXYQUINOLIN-8-YL)PENTANE-1,4-DIAMINE; BIS(PHOSPHORIC ACID)
200-560-8