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Tolpropamine

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Identification
Molecular formula
C13H20N2O
CAS number
83-14-1
IUPAC name
N-(o-tolyl)-2-(propylamino)propanamide
State
State

At room temperature, tolpropamine is in a solid state. It maintains its stability well under normal atmospheric conditions, making it suitable for storage as a pharmaceutical raw material.

Melting point (Celsius)
65.50
Melting point (Kelvin)
338.70
Boiling point (Celsius)
188.50
Boiling point (Kelvin)
461.60
General information
Molecular weight
207.31g/mol
Molar mass
207.3120g/mol
Density
1.0358g/cm3
Appearence

Tolpropamine is typically a white to off-white crystalline powder. It does not have any notable odor and is usually used in its pure form for pharmaceutical applications.

Comment on solubility

Solubility of N-(o-tolyl)-2-(propylamino)propanamide

N-(o-tolyl)-2-(propylamino)propanamide, with the chemical formula C13H20N2O, exhibits a range of solubility characteristics that are important for its applications in various fields. Understanding its solubility can be summarized with the following key points:

  • Polarity: The presence of the amine group (–NH2) and the hydroxyl group (–OH) in the structure of N-(o-tolyl)-2-(propylamino)propanamide contributes to its overall polarity, which influences its solubility.
  • Solvent Interaction: This compound is generally soluble in polar solvents such as water and alcohols due to hydrogen bonding capabilities. It may exhibit limited solubility in nonpolar solvents owing to its polar functional groups.
  • Temperature Dependence: Solubility can increase with temperature; therefore, higher temperatures may help dissolve this compound more effectively in certain solvents, potentially increasing its efficacy in applications.
  • pH Influence: The solubility can also be affected by the pH of the environment. In acidic or basic conditions, the protonation or deprotonation of the amine group can lead to increased solubility.

In conclusion, the solubility of N-(o-tolyl)-2-(propylamino)propanamide is a complex interplay of its molecular structure and the nature of the solvent. To optimize its use in practical applications, it is essential to consider these solubility characteristics.

Interesting facts

N-(o-tolyl)-2-(propylamino)propanamide

N-(o-tolyl)-2-(propylamino)propanamide is a fascinating compound that belongs to the family of amides, which are characterized by the presence of a carbonyl group bonded to a nitrogen atom. This compound stands out due to its unique structure and potential applications in various fields.

Interesting Aspects

  • Biological Roles: Compounds like N-(o-tolyl)-2-(propylamino)propanamide can play significant roles in biochemical processes, often acting as intermediates in the synthesis of pharmaceuticals. 
  • Synthetic Relevance: The synthesis of this compound often utilizes amino alkylation methods, which can provide insight into new synthetic pathways that can be explored in organic chemistry.
  • Potential Applications: Due to its structural similarities with certain biological molecules, this compound may be researched for its potential therapeutic effects or as a building block in drug design.
  • Structure-Activity Relationship (SAR): Understanding how the addition of the o-tolyl group or the propyl amino moiety affects the compound's activity can provide valuable information for medicinal chemistry.

As a student or researcher, exploring the properties and reactions of N-(o-tolyl)-2-(propylamino)propanamide may lead to exciting discoveries in medicinal chemistry or materials science.

In summary, N-(o-tolyl)-2-(propylamino)propanamide serves as a reminder of the complexity and beauty of organic chemistry, where even a single modification to a molecule can potentially transform its properties and applications.

Synonyms
prilocaine
721-50-6
Propitocaine
Citanest
prilocaine base
Prilocaina
Prilocainum
N-(2-Methylphenyl)-2-(propylamino)propanamide
Astra 1515
Propanamide, N-(2-methylphenyl)-2-(propylamino)-
o-Methyl-2-propylaminopropionanilide
2-(Propylamino)-o-propionotoluidide
o-Propionotoluidide, 2-(propylamino)-
Astra 1512
o-Methyl-alpha-propylaminopropionanilide
2-Methyl-alpha-propylaminopropionanilide
alpha-n-Propylamino-2-methylpropionanilide
Prilocainum [INN-Latin]
Prilocaina [INN-Spanish]
(+/-)-Prilocaine
NSC 40027
Prilotekal
CHEBI:8404
HSDB 3386
o-Propionotoluidide, 2-propylamino-
EINECS 211-957-0
NSC-40027
BRN 2108498
Propitocaine (JAN)
ASTRA-1512
ASTRA-1515
UNII-046O35D44R
2-Methyl-.alpha.-propylaminopropionanilide
046O35D44R
L 67
N-(2-methylphenyl)-N(2)-propylalaninamide
DL-(+/-)-PRILOCAINE
EMLA COMPONENT PRILOCAINE
DTXSID7031955
ORAQIX COMPONENT PRILOCAINE
Prilocaine [USAN:USP:INN:BAN]
FORTACIN COMPONENT PRILOCAINE
NSC40027
o-Propionotuluidide, 2-propylamino-
Prilocaine [USAN]
Prilocainum (INN-Latin)
Prilocaina (INN-Spanish)
PROPITOCAINE [JAN]
PRILOCAINE (MART.)
PRILOCAINE [MART.]
PRILOCAINE (USP-RS)
PRILOCAINE [USP-RS]
(+/-)-N-(2-PROPYLAMINOPROPIONYL)-2-TOLUIDINE
N-(2,6-DIMETHYLPHENYL)-2-(PROPYLAMINO)PROPANAMIDE
PRILOCAINE (EP MONOGRAPH)
PRILOCAINE [EP MONOGRAPH]
(R)-Prilocaine
(S)-Prilocaine
PRILOCAINE (USP MONOGRAPH)
PRILOCAINE [USP MONOGRAPH]
Prilocaine (USAN:USP:INN:BAN)
2-(Propylamino)-N-(o-tolyl)propanamide
Prilocaine (USP/INN)
Prilocain
MFCD00048681
Prilocaine (Standard)
N-(2-methylphenyl)-N2-propylalaninamide
Spectrum_001649
PRILOCAINE [MI]
PRILOCAINE [INN]
Prestwick0_000199
Prestwick1_000199
Prestwick2_000199
Prestwick3_000199
Spectrum2_001549
Spectrum3_001052
Spectrum4_001192
Spectrum5_001175
(.+/-.)-Prilocaine
PRILOCAINE [HSDB]
PRILOCAINE [VANDF]
CHEMBL1194
PRILOCAINE [WHO-DD]
Lopac0_001005
SCHEMBL25467
BSPBio_000157
BSPBio_002604
KBioGR_001883
KBioSS_002129
DivK1c_000846
SPBio_001398
SPBio_002078
BPBio1_000173
GTPL7276
DTXCID5011955
PRILOCAINE [ORANGE BOOK]
HY-B0137R
KBio1_000846
KBio2_002129
KBio2_004697
KBio2_007265
KBio3_001824
N01BB04
NINDS_000846
HMS3604H09
HMS3651M13
HMS3884A04
HY-B0137
PAA28931
PAA28932
PRILOCAINE COMPONENT OF EMLA
BDBM50225477
s1619
STL257086
2-(propylamino)-N-o-tolylpropanamide
PRILOCAINE COMPONENT OF ORAQIX
AKOS015889404
AC-2100
CCG-205085
CS-1929
DB00750
PRILOCAINE COMPONENT OF FORTACIN
SDCCGSBI-0050978.P004
IDI1_000846
NCGC00015860-02
NCGC00015860-03
NCGC00015860-15
NCGC00162312-01
AS-14851
FP137966
o-Methyl-.alpha.-propylaminopropionanilide
SBI-0050978.P003
DB-055611
N-(2-methylphenyl)-N~2~-propylalaninamide
AB00053665
NS00000546
SW196783-3
.alpha.-n-Propyl-amino-2-methylpropionanilide
C07531
D00553
EN300-188120
AB00053665-12
AB00053665_13
AB00053665_14
A837435
N-(2-Methylphenyl)-2-(propylamino)propanamide #
Q413598
N-(2-methylphenyl)-2-(propylamino)propanimidic acid
Propranamide, N-(2-methylphenyl)-2-(propylamino)-
(RS)-N-(2-Methylphenyl)-2-(propylamino)propanamide
BRD-A53952395-001-02-4
BRD-A53952395-003-05-3
BRD-A53952395-003-15-2
BRD-A53952395-003-25-1
Z44530398
211-957-0