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Harmaline

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Identification
Molecular formula
C13H14N2O
CAS number
304-21-2
IUPAC name
N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide
State
State

At room temperature, harmaline is typically found in a solid crystalline form. It is stable and does not decompose easily under normal conditions.

Melting point (Celsius)
263.00
Melting point (Kelvin)
536.15
Boiling point (Celsius)
410.00
Boiling point (Kelvin)
683.15
General information
Molecular weight
213.26g/mol
Molar mass
213.2630g/mol
Density
1.2860g/cm3
Appearence

Harmaline is a white, crystalline solid known for its bright fluorescence under ultraviolet light. It is often stored as a hydrochloride salt, which also appears as crystalline powder.

Comment on solubility

Solubility of N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide

N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide, with the chemical formula C13H14N2O, exhibits interesting solubility characteristics that can significantly influence its applications in various fields.

In general, the solubility of this compound can be summarized as follows:

  • Solvent Dependence: The solubility of N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide is dependent on the solvent used. It tends to be soluble in polar organic solvents such as ethanol and methanol.
  • Temperature Influence: As with many organic compounds, increased temperature can enhance solubility. This phenomenon is often utilized in preparation and formulation processes.
  • pH Sensitivity: The solubility may be affected by the pH of the solution. Alterations in pH can impact the ionization of the carboxamide moiety, thus influencing overall solubility.
  • Hydrophobic Characteristics: Due to its aromatic nature, the compound exhibits some hydrophobic properties, which may limit its solubility in water.

As a note, it is important to consider that *"solubility is a key factor in determining the absorbance and distribution of compounds in biological systems,"* pointing out the relevance of understanding the solubility profile of N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide for pharmacological applications.

In conclusion, while N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide displays favorable solubility in specific organic solvents, careful consideration of environmental factors is crucial for optimizing its use in scientific and industrial applications.

Interesting facts

Interesting Facts about N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide

N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide is a fascinating chemical compound that belongs to the category of indole derivatives. Here are some interesting aspects of this compound:

  • Structural Significance: The structure of N-methyl-9H-pyrido[3,4-b]indole highlights its dual-ring system, which combines the features of both pyridine and indole. This fusion results in a highly versatile scaffold that can be leveraged for various biological activities.
  • Biological Activity: Research has indicated that compounds related to this structure often exhibit significant pharmaceutical properties. Structures similar to N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide have been studied for their potential as anti-cancer, anti-inflammatory, and anti-viral agents.
  • Medicinal Chemistry: The carboxamide functional group plays a critical role in enhancing the solubility and bioavailability of drugs. In the context of N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide, this can lead to promising therapeutic applications.
  • Natural Occurrence: Indole derivatives are not limited to synthetic pathways; they are also found in various natural products. The characteristics of N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide may mimic those found in naturally occurring compounds that exhibit psychoactive effects or play roles in plant defense mechanisms.

As chemists continue to investigate the potential of N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide, its applications in drug design and development could provide new insights into tackling complex diseases. A notable quote within the field aptly summarizes this intrigue: "Every new compound represents a potential breakthrough waiting to happen."

In conclusion, the compound N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide stands at the intersection of organic chemistry and medicinal science, offering a vibrant canvas for researchers and pharmaceutical chemists alike.

Synonyms
78538-74-6
N-Methyl-beta-carboline-3-carboxamide
FG 7142
FG-7142
N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide
FG7142
beta-Carboline-3-carboxylic acid N-methylamide
ZK-31906
60PO70N1BP
N-Methyl-9H-pyrido(3,4-b)indole-3-carboxamide
ZK 39106;LSU-65
9H-Pyrido(3,4-b)indole-3-carboxamide, N-methyl-
9H-Pyrido[3,4-b]indole-3-carboxamide, N-methyl-
beta-CCA methylamide
SR-01000075632
UNII-60PO70N1BP
ZK-39106
ss-CCA methylamide
N-Methyl-?-carboline-3-carboxamide
Tocris-0554
Lopac-E-006
Biomol-NT_000283
Lopac0_000533
MLS000859935
SCHEMBL194445
BPBio1_001102
CHEMBL429711
CHEMBL1256141
3-carbomethylamide-beta-carboline
BDBM84955
CHEBI:93081
DTXSID30999832
QMCOPDWHWYSJSA-UHFFFAOYSA-N
HMS2234N11
HMS3261L07
HMS3266K18
HMS3369C04
HMS3411E10
HMS3675E10
HMS3752K21
CAS_4375
EX-A3473
NSC_4375
Tox21_500533
MFCD00055075
PDSP1_001762
PDSP2_001745
AKOS024458561
CCG-204623
LP00533
SDCCGSBI-0050516.P002
NCGC00015391-01
NCGC00015391-02
NCGC00015391-03
NCGC00015391-04
NCGC00015391-05
NCGC00015391-06
NCGC00015391-11
NCGC00024649-01
NCGC00024649-02
NCGC00024649-03
NCGC00024649-04
NCGC00261218-01
AC-36405
AS-16895
BF160700
FG 7142?
SMR000326796
beta-carbolin-3-carboxylic acid methylamide
DB-361436
HY-100991
CS-0020671
E-006
EU-0100533
beta-carbolin-3-carboxylic acid N-methylamide
E75070
beta;-Carboline-3-carboxylic acid N-methylamide
Q5425452
SR-01000075632-1
SR-01000075632-3
BRD-K61951118-001-01-2
BRD-K61951118-001-07-9
N-METHYL-9H-PYRIDO(5,4-B)INDOLE-3-CARBOXAMIDE