Fluoxetine | Solubility of Things

Identification

Molecular formula

C₁₇H₁₈F₃NO

CAS number

54910-89-3

IUPAC name

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

State

At room temperature, fluoxetine is typically found in a solid state.

Melting point (Celsius)

179.00

Melting point (Kelvin)

452.15

Boiling point (Celsius)

224.50

Boiling point (Kelvin)

497.65

General information

Molecular weight

309.33g/mol

Molar mass

309.3320g/mol

Density

1.1740g/cm³

Appearence

Fluoxetine is a white to off-white crystalline solid that is nearly odorless.

Comment on solubility

Solubility Overview

The compound N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, with the chemical formula C₁₇H₁₈F₃NO, presents an interesting case in terms of solubility due to its unique molecular structure. Here are some key points regarding its solubility:

Polar vs. Non-Polar: The presence of the trifluoromethyl group and the nitrogen functional group contribute to the polar characteristics of this compound, which can enhance solubility in polar solvents such as water.
Solvent Interaction: Although this compound has polar features, the large non-polar phenyl groups may impede complete solubility in water. Therefore, it may exhibit better solubility in organic solvents like ethanol, methanol, or acetone.
Temperature Effects: Solubility can also be influenced by temperature. Typically, increased temperatures can enhance solubility, allowing for greater dissolution of the compound in appropriate solvents.
Practical Applications: Understanding the solubility of this compound is essential for its potential applications in pharmaceuticals and chemical synthesis, ensuring optimal conditions for its use.

In conclusion, while N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine exhibits some polar tendencies, the overall solubility characterization will depend significantly on the choice of solvent and environmental conditions. As always, conducting empirical solubility tests is recommended for precise applications.

Interesting facts

Exploring N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, commonly referred to by its complex name, is an intriguing compound that melds structural elegance with functional utility. This compound exhibits an array of interesting characteristics:

Pharmacological Significance: Compounds like this one are often investigated in medicinal chemistry due to their potential influence on biological activity. Variations in substitution patterns can lead to different interactions with biological targets.
Trifluoromethyl Group: The presence of the trifluoromethyl group is particularly noteworthy. This moiety not only enhances lipophilicity, which can increase bioavailability, but also contributes unique electronic properties that can modify the compound's reactivity and interaction with receptors.
Synthetic Routes: The synthetic strategies employed to create this compound typically involve multiple steps, including substitution reactions and functional group transformations. Understanding these methodologies is crucial for the development of similar molecules.
Applications in Research: The compound serves as a valuable tool for researchers in both chemical and biomedical fields, potentially aiding in the development of new therapeutic agents.

Conclusion

In summary, N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine stands out due to its unique structure and potential applications. As researchers continue to explore such compounds, we can anticipate exciting developments in drug discovery and organic synthesis. As one scientist aptly said, "In the world of chemistry, every compound tells a story—it's up to us to decode its secrets."

Synonyms

fluoxetine

54910-89-3

Prozac

Fluoxetina

Pulvules

Eufor

Animex-On

Fluoxetin

Fluval

Portal

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

Fluoxetinum

Fluoxetina [Spanish]

Fluoxetinum [INN-Latin]

Fluoxetina [INN-Spanish]

Fluoxetin ratiopharm

Fluoxetine-d5

Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine

UNII-01K63SUP8D

N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine

NSC-283480

dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine

01K63SUP8D

DTXSID7023067

(+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine

(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine

CHEMBL41

57226-07-0

NSC-758685

CHEBI:5118

DTXCID903067

CHEBI:86990

(+) or (-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine

NSC 283480

NSC 758685

(+/-)-Fluoxetine

NCGC00015428-08

n-methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine

Fluoxetinum (INN-Latin)

Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine

Fluoxetina (INN-Spanish)

N-methyl-3-[4-(trifluoromethyl)phenoxy]-3-(3-tritiophenyl)propan-1-amine

Fluoxetine [USAN:INN:BAN]

N-methyl-3-phenyl-3-{[4-(trifluoromethyl)phenyl]oxy}propan-1-amine

BENZENEPROPANAMINE, N-METHYL-G-(4-(TRIFLUOROMETHYL)PHENOXY)-, (+/-)-

FLUOXETINE (EMA EPAR VETERINARY)

Fluoxetine (TN)

FLUOXETINE [EMA EPAR VETERINARY]

CAS-54910-89-3

Fluoxetine (USAN/INN)

fluoexetine

N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine

Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-

MFCD00072041

Spectrum_001679

FLUOXETINE [MI]

SpecPlus_000723

FLUOXETINE [INN]

Prestwick0_000511

Prestwick1_000511

Prestwick2_000511

Prestwick3_000511

Spectrum2_001658

Spectrum3_001648

Spectrum4_000613

Spectrum5_001518

FLUOXETINE [USAN]

Benzenepropamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-

FLUOXETINE [VANDF]

Biomol-NT_000152

Epitope ID:224550

(+) or (-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine

SCHEMBL8353

LY-110140 free base

FLUOXETINE [WHO-DD]

Lopac0_000558

BSPBio_000461

BSPBio_003375

GTPL203

KBioGR_001166

KBioSS_002159

cid_62857

DivK1c_006819

SPBio_001815

SPBio_002382

BPBio1_000354

BPBio1_000509

BDBM30130

KBio1_001763

KBio2_002159

KBio2_004727

KBio2_007295

KBio3_002595

3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine

N06AB03

PS06 - Fluoxetine/Norfluoxetine

HMS2090H14

(+/-)-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine

ALBB-025606

BCP28440

HY-B0102

Tox21_110144

(+/-)-N-Methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine

(+/-)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]

(+/-)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine

AB9783

BBL012251

NS-140

NSC283480

STK734483

AKOS003663021

Tox21_110144_1

AC-8478

CCG-204648

DB00472

SDCCGSBI-0050541.P004

(+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine

NCGC00015428-06

NCGC00015428-07

NCGC00015428-10

NCGC00015428-11

NCGC00015428-12

NCGC00015428-13

NCGC00015428-15

NCGC00015428-27

NCGC00024879-03

NCGC00024879-04

AS-44989

FF100299

SBI-0050541.P003

DB-015148

AB00053774

NS00000284

D00326

EN300-199668

AB00053774-13

AB00053774-14

AB00053774_15

AB00053774_16

L000931

Q422244

BRD-A31159102-001-01-9

BRD-A31159102-003-05-6

BRD-A31159102-003-16-3

BRD-A31159102-003-28-8

BRD-A31159102-003-29-6

BRD-A31159102-003-30-4

SR-01000002988-18

LY-110140;LY 110140;LY110140

N-methyl 3-(p-trifluoromethylphenoxy)-3-phenylpropylamine

N-Methyl-3-phenyl-3-(p-trifluoromethylphenoxy)propylamine

Benzenepropanamine, N-methyl-?-[4-(trifluoromethyl)phenoxy]-

N-methyl-gamma-(4-(trifluoromethyl)-phenoxy)-benzenepropanamine

benzenepropanamine, N-methyl-gamma-[4-(trifluoromethyl)phenoxy]-

DL-N-METHYL-3-(P-TRIFLUOROMETHYLPHENOXY)-3-PHENYLPROPYLAMINE

N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine #

Benzenepropanamine, N-methyl-gamma-[4-(trifluoromethyl)phenoxy]-, (+/-)-

methyl{3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}amine hydrochloride

N-METHYL-.GAMMA.-(4-(TRIFLUOROMETHYL)PHENOXY)BENZENEPROPANAMINE

N-methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine

(+/-)-N-METHYL-3-PHENYL-3-((alpha,ALPHA.,alpha-TRIFLUORO-P-TOLYL)OXY)PROPYLAMINE

(.+/-.)-N-Methyl-3-phenyl-3-[(.alpha.,.alpha.,.alpha.-trifluoro-p-tolyl)oxy]propylamine

(.+/-.)-N-Methyl-3-phenyl-3-[(.alpha.,la,.alpha.-trifluoro-p-tolyl)oxy]propylamine

Benzenepropanamine, N-methyl-.gamma.-[4-(trifluoromethyl)phenoxy]-, (.+/-.)-

(+/-)-N-METHYL-3-PHENYL-3-((.ALPHA.,ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)OXY)PROPYLAMINE