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Imatinib

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Identification
Molecular formula
C29H31N7O
CAS number
152459-95-5
IUPAC name
N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]pyridine-3-carboxamide
State
State

At room temperature, Imatinib is in a solid state, existing as a crystalline powder.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
1 048.00
Boiling point (Kelvin)
1 321.15
General information
Molecular weight
493.60g/mol
Molar mass
493.6030g/mol
Density
1.3200g/cm3
Appearence

Imatinib is typically seen as a white to off-white powder. Its crystalline nature contributes to this appearance, and it is usually marketed in solid form for oral administration as tablets or capsules.

Comment on solubility

Solubility of N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]pyridine-3-carboxamide

The solubility of N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]pyridine-3-carboxamide (C29H31N7O) can present intriguing characteristics worth exploring. This compound is a complex organic molecule featuring various functional groups that can influence its solubility in different solvents. Here are some key points to consider:

  • Polar vs. Non-Polar Solvents: Due to the presence of nitrogen and the carboxamide group, this compound is generally more soluble in polar solvents, such as dimethyl sulfoxide (DMSO) and water, compared to non-polar solvents like hexane.
  • Hydrophobic and Hydrophilic Interactions: The hydrophobic aromatic rings may limit solubility in highly polar environments, while hydrophilic components might enhance interactions with water, leading to variable solubility.
  • pH Dependency: The solubility could change with pH levels, especially within biological contexts, where functional groups can ionize.

In summary, the solubility of this compound is dictated by structural features and environmental factors. Hence, conducting solubility tests under various conditions can yield valuable insights into its behavior in different solvents.

Interesting facts

Interesting Facts about N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]pyridine-3-carboxamide

This compound, known for its complex structure, is a fascinating example of organic chemistry in action. It combines multiple functional groups and heterocycles, illustrating the diversity of chemical bonding and molecular design.

Key Features:

  • Targeted Therapeutics: This compound has garnered interest in the pharmaceutical industry due to its potential role as an inhibitor in targeted therapies.
  • Heterocyclic Compounds: The presence of pyridine and pyrimidine rings showcases the importance of heterocyclic chemistry in drug development, where these structures often contribute to biological activity.
  • Structure-Activity Relationship (SAR): The variations in the molecular structure can significantly affect biological interactions and efficacy, making this compound a valuable subject for SAR studies.

Moreover, the intricate arrangement of the functional groups in this compound allows for diverse interactions within biological systems. By modifying substituents on the pyrimidine or methyl groups, researchers can explore enhancements in potency or selectivity against specific targets.

Quote from a Chemical Perspective:

"The beauty of organic synthesis lies in its ability to create complex molecules with unique properties that can lead to groundbreaking therapies."

This compound represents just one of many in the rich tapestry of medicinal chemistry, embodying the art of molecular design and the promise of innovation in healthcare.

Synonyms
WGB-BC15
WGB-BC-15
n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamide
Q8SP783P3P
UNII-Q8SP783P3P
309760-28-9
3-Pyridinecarboxamide, N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-
N-(4-Methyl-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)phenyl)pyridine-3-carboxamide
N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)pyridine-3-carboxamide
N-(4-Methyl-3-((4-(3-Pyridinyl)-2-Pyrimidinyl)Amino)Phenyl)-3-Pyridinecarboxamide
N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)pyridine-3-carboxamide
N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}pyridine-3-carboxamide
PRC
SCHEMBL2004455
DB03878
PD007160
NS00070463
Q27094749