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Loratadine Hydrochloride

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Identification
Molecular formula
C22H24ClN3O
CAS number
100643-71-8
IUPAC name
N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-yl-ethane-1,2-diamine;hydrochloride
State
State

At room temperature, Loratadine Hydrochloride is typically in a solid state, appearing as a powder or crystalline solid. It is stable under normal conditions and does not readily evaporate into the atmosphere.

Melting point (Celsius)
133.00
Melting point (Kelvin)
406.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
447.91g/mol
Molar mass
447.9270g/mol
Density
1.1594g/cm3
Appearence

The compound typically appears as a white to off-white powder, which is crystalline in nature. It is usually free-flowing and may have slight variations in shade depending on the degree of purity and specific form in which it is prepared, such as anhydrous or monohydrate.

Comment on solubility

Solubility of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-yl-ethane-1,2-diamine;hydrochloride (C22H24ClN3O)

The solubility of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-yl-ethane-1,2-diamine;hydrochloride is influenced by several factors, primarily the interactions of its functional groups with different solvents.

Key Factors Affecting Solubility:

  • Polarity: Due to the presence of the hydrochloride salt form, this compound tends to be more soluble in polar solvents, particularly water.
  • Hydrogen Bonding: The nitrogen atoms in the structure can engage in hydrogen bonding, enhancing solubility in protic solvents.
  • Substituent Effects: The methoxy group on the phenyl ring can impact the overall solubility by influencing the molecule's hydrophobic characteristics.
  • Salt Formation: The hydrochloride salt form generally improves solubility compared to its non-salt form.

As a result, one can expect this compound to exhibit good solubility in aqueous solutions, making it suitable for pharmaceutical applications where solubility is paramount. In non-polar solvents, however, solubility may be significantly reduced due to the compound's polar characteristics.

In summary, the solubility of this compound is characterized by:

  1. High solubility in water and other polar solvents.
  2. Varied solubility in organic solvents depending on polarity.
  3. Enhanced solubility due to the presence of polar functional groups.
Interesting facts

Interesting Facts about N'-[(4-Methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-yl-ethane-1,2-diamine; Hydrochloride

This compound, known as N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-yl-ethane-1,2-diamine; hydrochloride, is quite significant in several domains of chemistry and medicine. Here are some intriguing aspects:

  • Pharmaceutical Potential: Compounds like this one often serve as precursors for drug development. Their structural characteristics may enhance the potency of pharmaceutical agents and contribute to their selectivity for specific biological targets.
  • Versatile Structure: The incorporation of a pyrimidine ring—common in many biological systems—suggests potential for interaction with nucleic acids or other biomolecules, which makes it a suitable candidate for studying nucleic acid interactions.
  • Mechanistic Insight: Understanding how this compound interacts with biological systems can reveal critical pathways and mechanisms, offering insights into disease processes and therapeutic strategies.
  • Research Usage: The compound can be utilized as a useful chemical probe in biochemical research, helping scientists dissect complex cellular processes and understand signaling pathways.
  • Modification Opportunities: The presence of methoxy and dimethyl groups provides avenues for further chemical modifications, allowing chemists to create a library of derivatives for screening against various biological targets.

As showcased in high-impact research, compounds like this serve as essential building blocks in the chemistry of life, with implications for therapeutics and research alike. Embracing such complex structures can lead to innovative solutions in both medicinal and synthetic chemistry. As we often remind ourselves in the field, "the more we explore compounds, the more we unveil the mysteries of nature."

Synonyms
THONZYLAMINE HYDROCHLORIDE
63-56-9
Thonzylamine HCl
Anahist
Novohetramin
Resistab
Neohetramine hydrochloride
Thonzylaminium chloride
Thonzylamine hydrochloride [USAN]
CCRIS 6277
EINECS 200-561-3
NH 188
NSC-758388
6K9YKD48Y4
DTXSID8026147
2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyrimidine hydrochloride
Thonzylamine (hydrochloride)
2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyrimidine hydrochloride
DTXCID806147
2-((2-(Dimethylamino)ethyl)(p-methoxy-benzyl)amino)-pyrimidine hydrochloride
N,N-Dimethyl-N'-(4-methoxybenzyl)-N'-(2-pyrimidyl)ethylenediamine hydrochloride
N-p-Methoxybenzyl-N',N'-dimethyl-N-2-pyrimidinylethylene diamine hydrochloride
NSC 758388
THONZYLAMINE HYDROCHLORIDE [MI]
THONZYLAMINE HYDROCHLORIDE [JAN]
NCGC00095010-01
THONZYLAMINE HYDROCHLORIDE [MART.]
THONZYLAMINE HYDROCHLORIDE [WHO-DD]
Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, hydrochloride
1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyrimidinyl-, monohydrochloride
thonzylaminehydrochloride
CAS-63-56-9
N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine;hydrochloride
1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyrimidinyl-, monohydrochloride
THONZYLAMINE HYDROCHLORIDE (MART.)
N-(4-methoxybenzyl)-N-(2-(dimethylamino)ethyl)pyrimidin-2-amine
UNII-6K9YKD48Y4
2-((2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO)PYRIMIDINE HYDROCHLORIDE
PYRIMIDINE, 2-((2-(DIMETHYLAMINO)ETHYL)(P-METHOXYBENZYL)AMINO)-, MONOHYDROCHLORIDE
PYRIMIDINE, 2-[[2-(DIMETHYLAMINO)ETHYL](P-METHOXYBENZYL)AMINO]-, MONOHYDROCHLORIDE
ANHIST
Super anahist (TN)
SCHEMBL29417
SPECTRUM1503135
CHEMBL1529802
CHEBI:32219
HMS1922G17
Pharmakon1600-01503135
BCP07457
Tox21_111387
NSC758388
2- (2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino pyrimidine hydrochloride
AKOS040744750
Tox21_111387_1
CCG-213118
Thonzylamine hydrochloride (JAN/USAN)
NCGC00095010-02
NCGC00178145-03
TS-08133
NS00078929
D01801
L10182
Q27265046
N,N-DIMETHYL-N'-(P-METHOXYBENZYL)-N'-(2-PYRIMIDYL)ETHYLENEDIAMINE HYDROCHLORID
N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine hydrochloride
N-P-METHOXY-N'N'-DIMETHYL-N-2-PYRIMIDINYLETHYLENE DIAMINE HYDROCHLORIDE
N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyrimidin-2-yl)ethane-1,2-diamine hydrochloride
200-561-3
N-((4-METHOXYPHENYL)METHYL)-N'N'-DIMETHYL-N-2-PYRIMIDINYL-1,2-ETHANEDIAMINE MONOHYDROCHLORIDE