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Pyridoxal isonicotinoyl hydrazone

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Identification
Molecular formula
C14H13N3O3
CAS number
932-16-1
IUPAC name
N-[(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide
State
State

The compound is a solid at room temperature. It is relatively stable under normal conditions but should be stored properly to prevent degradation.

Melting point (Celsius)
186.50
Melting point (Kelvin)
459.65
Boiling point (Celsius)
403.15
Boiling point (Kelvin)
676.15
General information
Molecular weight
286.27g/mol
Molar mass
286.2900g/mol
Density
1.3732g/cm3
Appearence

The compound appears as a pale yellow solid. It has a crystalline structure and is typically available as a powder.

Comment on solubility

Solubility Characteristics of N-[(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide

N-[(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide is a fascinating compound with respect to its solubility profile. Understanding its solubility is crucial for its application in various chemical processes and formulations. Here are some key aspects of its solubility:

  • Polarity: The presence of a hydroxyl group and methoxy group enhances its polarity, which could lead to improved solubility in polar solvents like water.
  • Hydrogen Bonding: The functional groups in this compound can engage in hydrogen bonding, which is typically favorable for solubility in aqueous solutions.
  • Solvent Compatibility: While it may dissolve well in alcohols and water due to its polar characteristics, it might display lower solubility in nonpolar solvents like hydrocarbons.
  • Temperature Influence: Like many compounds, solubility can vary significantly with temperature; higher temperatures often increase solubility.
  • pH Dependence: Given its amide and phenolic functionalities, the solubility might also be affected by the pH of the solution, considering the possibility of ionization.

In summary, one could anticipate that N-[(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide should exhibit reasonable solubility in polar solvents, influenced largely by its functional groups and environmental conditions. Understanding these factors provides essential insights into its potential applications and biochemical interactions.

Interesting facts

Interesting Facts about N-[(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide

This compound, known for its intricate structure and diverse applications, showcases the fascinating world of organic chemistry. Here are some notable aspects:

  • Chemical Structure: The compound features a unique combination of a pyridine ring and a phenolic moiety, which contributes to its interesting properties and potential biological activity.
  • Biological Significance: Compounds of this class are often explored for their pharmacological potential, including anti-inflammatory and anti-cancer properties. Researchers are keen to investigate how such structures interact with biological targets.
  • Application in Research: The versatility of N-[(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide makes it a valuable intermediate in synthetic organic chemistry, particularly in the development of pharmaceuticals.
  • Potential for Modification: Scientists can modify its structure to enhance its activity or selectivity towards specific biological targets. This makes it an exciting compound for medicinal chemists.
  • Interest in Green Chemistry: The synthesis of this compound can be approached through various methods, including environmentally friendly reactions, supporting the principles of green chemistry.

Overall, N-[(4-hydroxy-3-methoxy-phenyl)methyleneamino]pyridine-4-carboxamide is a compelling study subject for students and researchers alike, providing insights into medicinal chemistry, structural biology, and the design of new therapeutic agents.

Synonyms
Phthivazid
Ftivazide [INN]
Isonicotinic acid vanillylidenehydrazide
Ftivazidum
Phthivazidum
Phtivazide
Ftivazida
Phtivazid
Ftivazidum [INN-Latin]
Ftivazida [INN-Spanish]
FTIVAZIDE [MART.]
FTIVAZIDE [WHO-DD]
Phthivazide
Vanillaberon
Ftivazid
Vancide
Vanicid
Vanizide
149-17-7
UNII-40Q4C3O4V0
DTXSID3020758
40Q4C3O4V0
NSC 31725
BRN 0234808
Ftivazidum (INN-Latin)
Ftivazida (INN-Spanish)
FTIVAZIDE (MART.)
4-22-00-00598 (Beilstein Handbook Reference)
NSC-31725
4-Pyridinecarboxylic acid, ((4-hydroxy-3-methoxyphenyl)methylene)hydrazide
CBDivE_006720
CBDivE_008541
DTXCID10758
HMS2233N12
HMS3371I17
AKOS016869028
Acid Vanillylidenehydrazide, Isonicotinic
Vanillylidenehydrazide, Isonicotinic Acid
Phthivazid 100 microg/mL in Acetonitrile
SR-01000787185
Q4493190
SR-01000787185-4
isonicotinic acid 3-methoxy-4-hydroxybenzylidenehydrazide
4-Pyridinecarboxylic acid, ((4-hydroxy-3-methoxyphenyl)methylene)hydrazide (9CI)