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Bicalutamide

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Identification
Molecular formula
C18H14F4N2O4S
CAS number
90357-06-5
IUPAC name
N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
State
State

At room temperature, bicalutamide is in a solid state as a crystalline powder.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.15
Boiling point (Celsius)
508.90
Boiling point (Kelvin)
782.05
General information
Molecular weight
430.37g/mol
Molar mass
430.3670g/mol
Density
1.3496g/cm3
Appearence

Bicalutamide appears as a white to off-white crystalline powder. It is practically insoluble in water, slightly soluble in methanol, and soluble in ethanol.

Comment on solubility

Solubility of N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide

This compound exhibits interesting solubility characteristics that are influenced by its molecular structure. N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide is generally considered soluble in a variety of organic solvents. Notable points regarding its solubility include:

  • Soluble in Organic Solvents: The presence of acetyl and sulfonyl groups enhances its interaction with polar organic solvents such as dimethyl sulfoxide (DMSO) and ethanol.
  • Poor Water Solubility: Due to its relatively large molecular size and hydrophobic regions, the compound exhibits limited solubility in water.
  • Temperature Dependence: As is typical for many organic compounds, solubility may increase with temperature, making heating a possible method to improve dissolution.

In summary, one can conclude that the solubility of N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide is best achieved in organic solvents, while its behavior in aqueous environments tends to be restricted and requires careful consideration for applications. Understanding these solubility dynamics is crucial for its effective use in chemical formulations.

Interesting facts

Interesting Facts About N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide

N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide, often referred to in scientific literature, is a compound that attracts attention due to its intriguing properties and potential applications.

Key Highlights

  • Pharmaceutical Relevance: This compound is a member of the sulfonamide drug class, which are known for their antibacterial properties. They work by inhibiting the synthesis of folic acid in bacteria, thereby preventing their growth.
  • Structure Activity Relationship: The structural complexity of this compound allows for exciting studies in medicinal chemistry. The positioning of the acetamido and sulfonyl groups plays a critical role in determining its biological activity.
  • Versatile Applications: Beyond its use in pharmaceuticals, compounds like N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide can be explored for applications in dye manufacturing, agrochemicals, and even in material science.
  • Research Potential: Its unique structure makes it a target for ongoing research in drug design and discovery. Scientists are continuously investigating its efficacy and safety in various biological settings.

Did You Know?

Compounds similar to N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide are often used in studies focusing on inhibition pathways in microbial resistance, prompting insights into how to combat antibiotic resistance.

Moreover, the presence of sulfonyl groups in its architecture often enhances the solubility and stability of the compound, which is a crucial factor for drug formulations.

In summary, N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide serves not only as a significant molecule in medicinal chemistry but also as a solid platform for interdisciplinary research crossing into fields like biology, pharmacology, and environmental science.

Synonyms
Acedapsone
77-46-3
Diacetyldapsone
Sulfadiamine
Hansolar
Acetamin
Sulfodiamin
Sulfodiamine
DADDS
Acedapsona
Camilan
Atilon
Acedapsonum
Rodilone
N,N'-Diacetyldapsone
p,p'-Sulfonylbisacetanilide
PAM-MR-1165
Acedafsonum
Acedafsonum [Latin]
Acedapsona [Spanish]
CN-1883
Bis(4-acetamidophenyl)sulfone
4',4'''-Sulfonylbis(acetanilide)
Bis(p-acetamidophenyl) sulfone
4,4'-Diacetyldiaminodiphenyl sulfone
CI 556
N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
Bis(4-acetamidophenyl) sulfone
Di-(p-acetylaminophenyl)sulfone
Sulfone, bis(p-acetamidophenyl)
Acedapsonum [INN-Latin]
Acedapsona [INN-Spanish]
4,4'-Diacetamidodiphenyl sulfone
4,4'-Diacetylaminodiphenyl sulfone
4',4'''-Sulfonylbis(acetanilidec)
N,N'-Diacetyl-4,4'-diaminodiphenylsulfone
Acedapsone [USAN:INN:BAN]
N,N'-(Sulfonyldi-4,1-phenylene)bisacetamide
CCRIS 5694
4,4'-Bis(acetylamino)diphenyl sulfone
BA 2650
N,N'-Diacetyl-4,4'-diaminodiphenyl sulfone
Acetanilide, 4',4'''-sulfonyldi-
EINECS 201-028-8
4,4'-Sulfonylbisacetanilide
CI-556
Hansolar (TN)
1399 F
NSC 218125
NSC 655049
NSC-218125
NSC-655049
CN 1883
Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis-
BRN 2164071
0GZ72U84TN
PAM MR 1165
AI3-32581
N,N'-Diacetyl-4,4'-diaminophenyl sulfone
ACEDAPSONE [MI]
ACEDAPSONE [INN]
ACEDAPSONE [USAN]
Acetamide. N,N'-(sulfonyldi-4,1-phenylene)bis-
ACEDAPSONE [MART.]
1399FCI-556
ACEDAPSONE [WHO-DD]
ACETANILIDE, 4',4'''-SULFONYLBIS-
CHEBI:139474
4-13-00-01361 (Beilstein Handbook Reference)
Acedafsonum (Latin)
NSC218125
NSC655049
BIS(4-ACETAMIDOPHENYL)SULPHONE
4,4'-DIACETYLAMINODIPHENYL SULPHONE
Acedapsonum (INN-Latin)
4,4'-DIACETYLDIAMINODIPHENYL SULPHONE
Acedapsona (INN-Spanish)
N,N'-[sulfonyldi(4,1-phenylene)]diacetamide
ACEDAPSONE (MART.)
N,N'-DIACETYL-4,4'-DIAMINODIPHENYL SULPHONE
4',4'''-Sulfonylbis[acetanilide]
Acetyldiphenazonum
N,N'-(sulfonyldi(4,1-phenylene))diacetamide
UNII-0GZ72U84TN
4,4'-Diacetyldiaminodiphenylsulfone
Acedapsone (USAN/INN)
N,N'-(sulfonyldibenzene-4,1-diyl)diacetamide
N,4'-diaminophenyl sulfone
Oprea1_412338
Oprea1_531922
SCHEMBL152710
WLN: 1VMR DSWR DMV1
Acetanilide,4'''-sulfonyldi-
Acetanilide,4'''-sulfonylbis-
CHEMBL154166
Acetamide. N,1-phenylene)bis-
DTXSID1021295
SCHEMBL10341852
AMTPYFGPPVFBBI-UHFFFAOYSA-N
CHEBI:135417
HMS2093F05
Pharmakon1600-01505376
4,4' Diacetyldiaminodiphenylsulfone
AAA07746
NSC759111
AKOS001662412
CCG-213407
NSC-759111
C.I. 556
SBI-0206835.P001
EU-0078007
NS00021352
Acetamide,N'-(sulfonyldi-4,1-phenylene)bis-
D02751
N,N'-(Sulfonylbis(4,1-phenylene))diacetamide
AB00628276_02
SR-05000001921
Q2823819
SR-05000001921-1
BRD-K97417064-001-01-6
BRD-K97417064-001-02-4
N-(4-(4-ACETYLAMINO-BENZENESULFONYL)-PHENYL)-ACETAMIDE
201-028-8