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Afatinib

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Identification
Molecular formula
C24H25ClFN5O
CAS number
439081-18-2
IUPAC name
N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide
State
State

Afatinib is generally found as a solid at room temperature. It is often prepared and handled as a crystalline powder.

Melting point (Celsius)
241.50
Melting point (Kelvin)
514.65
Boiling point (Celsius)
614.15
Boiling point (Kelvin)
887.30
General information
Molecular weight
485.94g/mol
Molar mass
485.9370g/mol
Density
1.4208g/cm3
Appearence

Afatinib is typically a white to slightly yellowish powder.

Comment on solubility

Solubility of N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide

The solubility of N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide (C24H25ClFN5O) can be a crucial parameter in its applications in chemical research and pharmaceuticals. Understanding solubility is essential for determining how this compound will behave in various environments. Here are some key points regarding its solubility:

  • Polarity: The presence of both hydrophobic (aromatic) and hydrophilic (amide) groups suggests that the compound could exhibit variable solubility in different solvents.
  • Solvent Compatibility: It is likely to be more soluble in organic solvents, such as DMSO or ethanol, rather than in water due to its structural characteristics.
  • Temperature Effect: As with many organic compounds, solubility is expected to increase with temperature, making it important to consider thermal conditions during experimentation.
  • pH Influence: The solubility behavior might also change with pH levels, particularly because the amide group can interact with both acids and bases.

Due to these factors, experimental determination of solubility in different solvents and conditions is vital for practical use and application. As a general observation, *“Solubility is not just a number; it tells a story about how a compound interacts with its environment.”* Therefore, comprehensive testing is recommended to obtain reliable solubility data.

Interesting facts

N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide

This intriguing compound, known as N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide, is a member of the quinazoline family, which has garnered significant interest in medicinal chemistry due to its diverse biological activities.

Key Features:

  • Pharmacological Potential: Quinazoline derivatives often exhibit notable anticancer and antimicrobial properties, making them valuable in drug development.
  • Bromine Substitution: The presence of bromine in this compound can enhance biological activity and selectivity, a common strategy in medicinal chemistry to fine-tune the properties of lead compounds.
  • Structural Complexity: The intricate structure of this molecule highlights the complexity and versatility of synthetic organic chemistry, providing numerous possibilities for further modifications.

Applications in Research:

Due to its unique structural characteristics, this compound has potential applications in various fields:

  • Anticancer Research: Compounds like this one are under investigation for their ability to inhibit cancer cell growth through various mechanisms.
  • Drug Design: It serves as a scaffold in the development of novel therapeutics targeting specific pathways involved in disease progression.
  • Biochemical Studies: Researchers explore its interactions with biological targets, contributing to the understanding of disease mechanisms.

In summary, N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide represents a rich area of exploration for chemists and pharmacologists alike. As we delve deeper into the properties and potential of such compounds, we continue to uncover the vast possibilities they hold in advancing human health.

Synonyms
194423-15-9
PD168393
PD-168393
4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
pd 168393
N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide
n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide
N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide
3R996Y9T0I
CHEMBL285063
2-Propenamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-
CHEBI:131504
DTXSID80274444
PD 168393 [WHO-DD]
nchembio866-comp2
4-((3-Bromophenyl)amino)-6-Acrylamidoquinazoline
N-(4-(3-bromoanilino)quinazolin-6-yl)prop-2-enamide
N-[4-[(3-bromophenyl)amino]quinazolin-6-yl]acrylamide
N-(4-((3-bromophenyl)amino)quinazolin-6-yl)prop-2-enamide
UNII-3R996Y9T0I
MFCD02179207
3968-03-4
BMC163482 Compound 1
4-anilinoquinazoline deriv. 2
BDBM4567
SCHEMBL2680536
DTXCID50225923
EX-A808
HTUBKQUPEREOGA-UHFFFAOYSA-N
HMS3652F18
BCP07986
UHA42315
HSCI1_000120
s7039
AKOS027337569
CCG-268278
CS-5723
DB07662
SB19366
NCGC00386260-01
NCGC00386260-02
AC-32813
AS-67687
DA-43376
HY-13896
PD168393?
NS00068483
SW218184-2
F13662
PD168393, >=98% (HPLC)
BRD-K17702546-001-03-2
N-(4-(3-Bromophenylamino)quinazolin-6-yl)acrylamide
Q26998221
N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide;4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline