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Belinostat

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Identification
Molecular formula
C8H15N3O4
CAS number
414864-00-9
IUPAC name
N-[4-[[1-(hydroxycarbamoyl)-2-methyl-propyl]-(2-morpholinoethyl)sulfamoyl]phenyl]-4-pentyl-benzamide
State
State

Belinostat is in a solid state at room temperature, typically appearing as a powder or crystalline solid depending on purity and form.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
318.15g/mol
Molar mass
318.1470g/mol
Density
0.9736g/cm3
Appearence

Belinostat is a white to off-white powder. It is generally provided as a crystalline solid for use in research and pharmaceutical applications.

Comment on solubility

Solubility of N-[4-[[1-(hydroxycarbamoyl)-2-methyl-propyl]-(2-morpholinoethyl)sulfamoyl]phenyl]-4-pentyl-benzamide

N-[4-[[1-(hydroxycarbamoyl)-2-methyl-propyl]-(2-morpholinoethyl)sulfamoyl]phenyl]-4-pentyl-benzamide, with the molecular formula C8H15N3O4, exhibits unique solubility characteristics due to its complex structure. Understanding its solubility properties is crucial for various applications.

Key Factors Influencing Solubility:

  • Polarity: The presence of functional groups such as -NH, -OH, and -SO2- can enhance solubility in polar solvents because they can interact favorably through hydrogen bonding.
  • Hydrophobic Interactions: The benzamide structure contributes hydrophobic characteristics, which can lead to reduced solubility in highly polar solvents.
  • pH Sensitivity: The solubility may vary significantly with changes in pH, particularly due to the presence of functional groups that can gain or lose protons.

Generally, compounds like this benzenesulfonamide may find better solubility in dimethyl sulfoxide (DMSO) or similar organic solvents as opposed to water, which can limit the utility for certain applications. As described by certain studies, "solubility is fundamentally a balance between forces of attraction and repulsion between solute and solvent molecules." This quote encapsulates the essence of understanding solubility in the context of complex molecules.

In conclusion, the solubility profile of this compound should be evaluated under various conditions to optimize its use in pharmaceutical formulations or other chemical applications.

Interesting facts

Interesting Facts about N-[4-[[1-(hydroxycarbamoyl)-2-methyl-propyl]-(2-morpholinoethyl)sulfamoyl]phenyl]-4-pentyl-benzamide

N-[4-[[1-(hydroxycarbamoyl)-2-methyl-propyl]-(2-morpholinoethyl)sulfamoyl]phenyl]-4-pentyl-benzamide is a compound that showcases the fascinating complexities of organic chemistry and drug design. Here are some interesting insights about this compound:

  • Multifunctionality: The structure of this compound incorporates various functional groups, including amides and sulfamides, which can enhance its interaction with biological targets.
  • Potential Therapeutic Use: Given its unique chemical structure, this compound may have applications in drug formulation, particularly in areas requiring innovative therapies for conditions like cancer or diabetes.
  • Structure-Activity Relationship (SAR): Chemists often explore how slight modifications in the compound’s structure can affect its biological activity, providing insight into optimizing pharmacological effects.
  • Design Challenges: The complexity of such compounds presents numerous challenges during synthesis and characterization, making it a fascinating topic of study in both synthetic and medicinal chemistry.
  • Research Frontiers: Compounds like this one are often at the forefront of research into new drug candidates, emphasizing the importance of continual chemical exploration and innovation.

In summary, N-[4-[[1-(hydroxycarbamoyl)-2-methyl-propyl]-(2-morpholinoethyl)sulfamoyl]phenyl]-4-pentyl-benzamide represents an exciting intersection of chemistry and medicine, illustrating how compounds can be designed for specific biological activities. As scientists continue to unravel the potential of such molecules, we can expect to see significant advances in therapeutic treatments.