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Salmeterol

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Identification
Molecular formula
C25H37NO4
CAS number
89365-50-4
IUPAC name
N-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide
State
State

At room temperature, salmeterol is a solid.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
374.15
Boiling point (Kelvin)
647.30
General information
Molecular weight
415.56g/mol
Molar mass
415.5550g/mol
Density
1.0800g/cm3
Appearence

Salmeterol appears as a white or almost white powder. It is usually crystalline in nature.

Comment on solubility

Solubility of N-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide (C25H37NO4)

This compound exhibits interesting solubility characteristics due to its unique chemical structure. Here are some key points to consider regarding its solubility:

  • Solvent Dependency: N-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide is likely to be soluble in a variety of solvents, particularly polar organic solvents such as ethanol and methanol.
  • Hydrophilic and Lipophilic Balance: The presence of the hydroxyl group and sulfonamide moiety contributes to its hydrophilic nature, while the isopropylamino group introduces lipophilicity, which enhances solubility in organic media.
  • pH Influence: The solubility may significantly change with pH; at lower pH levels, the compound can become protonated, increasing its solubility in aqueous environments.
  • Temperature Effects: Increasing the temperature can generally enhance solubility for many organic compounds, and this may apply to this sulfonamide as well.

In conclusion, the solubility of N-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide is influenced by multiple factors including solvent choice, pH, and temperature. This multifaceted nature allows for diverse applications across different fields.

Interesting facts

Interesting Facts about N-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide

This compound, known for its intricate structure, belongs to the class of sulfonamides, which have been pivotal in medical chemistry due to their wide-ranging therapeutic applications. Here are some noteworthy points about this intriguing compound:

  • Therapeutic Potential: Sulfonamides have historically been used as antibacterial agents. This particular compound's design suggests it may have potential uses in treating various infections or conditions related to the urological system.
  • Complex Structure: The inclusion of an isopropylamino group contributes to its biological activity. This structure can help modify the compound's interaction with biological targets, enhancing its pharmacological profile.
  • Hydroxyl Functional Group: The presence of the hydroxyl group is crucial, as it may facilitate hydrogen bonding, enhancing the compound's solubility and interaction with enzymes.
  • Research Focus: Compounds with similar frameworks are often the subjects of research aimed at developing new drugs. Understanding how the different functional groups interact with biological systems can lead to breakthroughs in pharmacology.

As a chemistry student or scientist delving into organic synthesis, studying such compounds not only enhances your knowledge of medicinal chemistry but also broadens your capability to design novel therapeutics. As researchers continue to explore the potential applications of this compound, its impact on future medical therapies may be significant.

"Chemical ingenuity often lies in the details of molecular architecture."

Synonyms
sotalol
3930-20-9
beta-Cardone
DL-Sotalol
Sotalolum
Darob mite
Sotalolum [INN-Latin]
N-(4-(1-Hydroxy-2-(isopropylamino)ethyl)phenyl)methanesulfonamide
(+-)-Sotalol
CCRIS 4204
4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide
.beta.-Cardone
N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide
Sotalol (INN)
UNII-A6D97U294I
Methanesulfonanilide, 4'-(1-hydroxy-2-(isopropylamino)ethyl)-
DTXSID0023589
CHEBI:63622
C07AA07
A6D97U294I
4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid
CHEMBL471
(+/-)-SOTALOL
Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-
DTXCID303589
N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
NCGC00015919-04
Sotalolum (INN-Latin)
SOTALOL [INN]
Sotalol [INN:BAN]
N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide
Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-
l-Sotalol
DL-4-(2-ISOPROPYLAMINO-1-HYDROXYETHYL)METHANESULFONANILIDE
4'-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)METHANESULFONANILIDE
N-{4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl}methanesulfonamide
N-(4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}phenyl)methanesulfonamide
N-(4-(1-HYDROXY-2-((1-METHYLETHYL)AMINO)ETHYL)PHENYL)METHANESULFONAMIDE
Darob mite (TN)
4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide
Sotalolo
N-(4-(1-hydroxy-2-(propan-2-ylamino)ethyl)phenyl)methanesulfonamide
Sotalol,(+)
Sotalol,(-)
SOTALOL [VANDF]
SOTALOL [MI]
Prestwick0_000966
Prestwick1_000966
Prestwick2_000966
Prestwick3_000966
SOTALOL [WHO-DD]
Lopac0_001055
SCHEMBL16407
BSPBio_000971
cid_66245
SPBio_002892
BPBio1_001069
GTPL7297
BDBM25762
HMS2089K09
ALBB-022454
Tox21_110261
AKOS015897340
CCG-205132
DB00489
SDCCGSBI-0051025.P003
NCGC00015919-03
NCGC00015919-05
NCGC00015919-06
NCGC00015919-07
NCGC00015919-14
NCGC00015919-18
NCGC00024899-02
NCGC00024899-03
AC-19021
CAS-3930-20-9
SBI-0051025.P002
DB-049399
AB00514715
NS00000195
C07309
D08525
AB00514715-09
AB00514715-10
AB00514715_11
AB00514715_12
EN300-7382649
L013427
Q413591
BRD-A33168282-003-03-2
BRD-A33168282-003-06-5
BRD-A33168282-003-16-4
BRD-A33168282-003-17-2
BRD-A33168282-003-18-0
4'-[1-Hhydroxy-2-(isopropylamino)ethyl]methanesulfonanilide
4'-[1-Hydroxy-2-(isopropylamino)ethyl]metahnesulfonanilide
aniline, 4-(1-hydroxy-2-isopropylamino)ethyl-N-methylsulphonyl-
N-(4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl)methanesulfonamide #