Skip to main content

Venetoclax

ADVERTISEMENT
Identification
Molecular formula
C45H50ClN7O7
CAS number
1257044-40-8
IUPAC name
N-[3-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide
State
State

At room temperature, venetoclax is a solid.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
868.44g/mol
Molar mass
868.4400g/mol
Density
1.2000g/cm3
Appearence

Venetoclax typically appears as an off-white to light yellow solid, crystalline in nature.

Comment on solubility

Solubility of N-[3-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide (C45H50ClN7O7)

The solubility of N-[3-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide is a critical aspect to consider, particularly for its application in various chemical and pharmaceutical contexts. Understanding its solubility can shed light on its behavior in different environments.

Key Points on Solubility

  • Polar vs. Non-Polar: The presence of polar functional groups such as amine and carbonyl may suggest moderate solubility in polar solvents, yet the overall large hydrophobic (non-polar) structure could hinder solubility in water.
  • Solvent Compatibility: This compound might dissolve better in organic solvents like ethanol or dimethyl sulfoxide (DMSO) than in aqueous solutions, highlighting the importance of solvent choice in experimental setups.
  • Temperature Dependence: Solubility can be significantly influenced by temperature, often increasing at elevated temperatures for many compounds, suggesting a potential avenue for enhancing dissolution in practical applications.
  • Impurity Effects: The presence of impurities can also affect solubility; unexpected interactions could lead to changes in solubility behavior, emphasizing the need for purity in analytical experiments.

In summary, while the solubility of N-[3-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide may not be readily classified, it requires careful consideration of its structural features and the environment in which it is placed. As with many complex molecules, predicting solubility can often be a nuanced challenge.

Interesting facts

Interesting Facts about N-[3-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide

N-[3-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide is a fascinating chemical compound with a highly intricate structure, showcasing the complexity and diversity of modern medicinal chemistry. Here are some intriguing insights about this compound:

  • Structural Composition: The compound features a unique combination of a benzamide moiety with a morpholino and chloro substituent, which can significantly influence its biological activity.
  • Pharmaceutical Relevance: Compounds like this are often studied for their potential therapeutic effects, particularly in areas such as oncology and infectious diseases, due to their ability to interact with specific biological targets.
  • Complex Interactions: The morpholino group is known for its role in enhancing cellular uptake of the compound, potentially increasing its efficacy in drug delivery systems.
  • Effects of Substituents: The presence of the chloro group can affect pharmacokinetics and pharmacodynamics, making this compound a candidate for structure-activity relationship (SAR) studies.
  • Future Research: Ongoing research may focus on elucidating how variations in the chemical structure could lead to improved potency or reduced side effects, which is a common objective in drug design and development.

In conclusion, N-[3-chloro-2-[[methyl-(2-morpholino-2-oxo-ethyl)amino]methyl]phenyl]benzamide exemplifies the challenges and opportunities present in the field of chemistry. As scientists continue to explore such complex molecules, they uncover new dimensions of therapeutic potential and chemical behavior.

Synonyms
FOMINOBEN
18053-31-1
Fominobene
Fominoben [INN]
Fominobenum
TJ2KK6NYJS
UNII-TJ2KK6NYJS
Fominobene [INN-French]
Fominobenum [INN-Latin]
Fominoben (INN)
Terion
PB 89 [AS HYDROCHLORIDE]
FOMINOBEN [MI]
EINECS 241-964-4
PB 89 FREE BASE
PB-89 FREE BASE
FOMINOBEN [WHO-DD]
3'-Chloro-2'-(N-methyl-N-((morpholino-carbonyl)methyl)aminomethyl)benzanilide
DTXSID1023075
N-[3-chloro-2-[[methyl-(2-morpholin-4-yl-2-oxoethyl)amino]methyl]phenyl]benzamide
Fominobene (INN-French)
Fominobenum (INN-Latin)
3'-Chloro-alpha-(N-methyl-N-((morpholinocarbonyl)methyl)aminomethyl)benzanilide
PB 89 (AS HYDROCHLORIDE)
N-(2-Benzoylamino-6-chlorobenzyl)-N-methylglycine morpholide; Terion
3'-Chloro-alpha-(methyl((morpholinocarbonyl)methyl)amino)-o-benzotoluidide
3'-CHLORO-.ALPHA.-(METHYL((MORPHOLINOCARBONYL)METHYL)AMINO)-O-BENZOTOLUIDIDE
N-(3-chloro-2-((methyl-(2-morpholin-4-yl-2-oxoethyl)amino)methyl)phenyl)benzamide
SCHEMBL498486
DTXCID403075
CHEMBL1697837
CHEBI:135639
AKOS015895116
DB08968
N-[3-chloro-2-[[methyl-[2-(4-morpholinyl)-2-oxoethyl]amino]methyl]phenyl]benzamide
DB-044398
NS00006644
D07988
A812546
Q20817276
N-(3-chloro-2-((methyl(2-morpholino-2-oxoethyl)amino)methyl)phenyl)benzamide
N-(3-chloro-2-{[methyl(2-morpholin-4-yl-2-oxoethyl)amino]methyl}phenyl)benzamide
241-964-4
N-[3-chloranyl-2-[[methyl-(2-morpholin-4-yl-2-oxidanylidene-ethyl)amino]methyl]phenyl]benzamide