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Clopamide

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Identification
Molecular formula
C14H18ClN1O3S1
CAS number
7280-19-3
IUPAC name
N-(3-chloro-1-isopropyl-2-oxo-propyl)-4-methyl-benzenesulfonamide
State
State

Clopamide is a solid at room temperature, commonly found in the form of solid tablets or powder.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
315.50
Boiling point (Kelvin)
588.70
General information
Molecular weight
371.82g/mol
Molar mass
371.8670g/mol
Density
1.2900g/cm3
Appearence

Clopamide is typically a crystalline solid with white to off-white color. It may have a slight odor depending upon purity and environmental conditions.

Comment on solubility

Solubility of N-(3-chloro-1-isopropyl-2-oxo-propyl)-4-methyl-benzenesulfonamide

N-(3-chloro-1-isopropyl-2-oxo-propyl)-4-methyl-benzenesulfonamide, with the chemical formula C14H18ClN1O3S1, exhibits intriguing solubility characteristics that make it noteworthy in various contexts. Understanding its solubility is vital for applications in pharmaceuticals and industrial uses.

Factors Influencing Solubility

The solubility of this compound is influenced by several factors, including:

  • Polarity: The presence of polar functional groups, such as the sulfonamide group, enhances solubility in polar solvents.
  • Hydrogen Bonding: The compound can participate in hydrogen bonding, which can significantly increase solubility in water.
  • Temperature: Increased temperatures often lead to enhanced solubility for many organic compounds.

Solvent Compatibility

In general, the solubility profile of this compound can be summarized as follows:

  • Highly soluble in polar solvents like water and alcohols.
  • Moderately soluble in non-polar solvents due to its hydrophobic hydrocarbon structure.
  • Potentially insoluble in some organic solvents depending on their polarity and structure.

Overall, understanding the solubility of N-(3-chloro-1-isopropyl-2-oxo-propyl)-4-methyl-benzenesulfonamide is crucial for its practical applications, as solubility plays a key role in its bioavailability and reactivity in different environments.

Interesting facts

Interesting Facts about N-(3-Chloro-1-isopropyl-2-oxo-propyl)-4-methyl-benzenesulfonamide

N-(3-Chloro-1-isopropyl-2-oxo-propyl)-4-methyl-benzenesulfonamide is a compound that showcases the intriguing intersection of medicinal chemistry and organic synthesis. Here are some captivating facts about this compound:

  • Pharmaceutical Potential: This compound is part of a larger class of sulfonamide derivatives, which are known for their antibacterial properties. Its unique structure may contribute to potential applications in drug design.
  • Structural Complexity: The presence of various functional groups, including the chloro and sulfonamide moieties, illustrates the compound’s potential for reactivity and interaction with biological systems.
  • Research Interest: As a pharmaceutical candidate, the compound may spark interest in research focusing on the development of new therapeutics, particularly in combating antibiotic resistance.
  • Factors Influencing Activity: The spatial arrangement of the isopropyl group and the position of the chloro atom are significant, as they can enhance or inhibit biological activity through changes in interaction with target molecules.
  • Aromatic Sulfonamides: Compounds like this one that incorporate benzene derivatives are essential in the synthesis of dyes, pigments, and high-performance polymers, showcasing their versatility in both medicinal and industrial applications.

In summary, N-(3-Chloro-1-isopropyl-2-oxo-propyl)-4-methyl-benzenesulfonamide represents a fascinating compound within the realm of chemistry. Its complex structure combined with the potential for use in pharmaceutical applications highlights the importance of continual research into its properties and uses.

Synonyms
N-(3-Chloro-1-isopropylacetonyl)-p-toluenesulfonamide
26020-35-9
BRN 5573823
N-Tosyl-L-valine chloromethyl ketone
CHEMBL315893
p-Toluenesulfonamide, N-(3-chloro-1-isopropylacetonyl)-
DTXSID00948913
N-(1-Chloro-4-methyl-2-oxopentan-3-yl)-4-methylbenzene-1-sulfonamide