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Bleomycin

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Identification
Molecular formula
C55H84N17O21S2
CAS number
11056-06-7
IUPAC name
N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide
State
State

Bleomycin is administered as a solid powder, which is reconstituted into a solution form for intravenous injection.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
1415.55g/mol
Molar mass
1 415.5510g/mol
Density
1.2250g/cm3
Appearence

Bleomycin is typically available as a white to off-white powder. It is usually supplied in a sealed vial to protect it from moisture and light, as it is sensitive to degradation.

Comment on solubility

Solubility of N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide

The solubility of the compound C55H84N17O21S2 is influenced by several factors, which are worth noting:

  • Polarity: The large molecular structure with multiple functional groups, including amine and amide, tends to enhance solubility in polar solvents.
  • Hydrogen Bonding: The presence of numerous hydrogen bond donors and acceptors can facilitate interactions with water, often resulting in higher solubility.
  • Macromolecular Characteristics: The extensive polyfunctional nature and significant molecular weight may lead to increased viscosity in solutions, affecting overall solubility dynamics.
  • Solvent Choice: Likely solubility in organic solvents such as methanol or dimethyl sulfoxide (DMSO); however, lower solubility in nonpolar solvents may be expected due to the compound's polar groups.

In conclusion, while predictions about solubility can be made based on molecular structure and functional groups, empirical testing remains crucial for accurate solubility data. As stated, "The nature of solvents can greatly influence solubility, often unexpectedly." Always consider the specific conditions in which solubility is tested, including temperature and pH.

Interesting facts

Exploring the Complex Compound N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide

This impressive chemical compound is notable for its intricate structure and diverse functionality. Here are some fascinating aspects that highlight the significance of this molecule in medicinal chemistry:

  • Multifunctionality: The presence of multiple functional groups such as amino, carbamoyl, and hydroxy hints at its potential applications in drug development, particularly in creating multi-targeted therapies.
  • Complex Structure: The elaborate heptazacyclotricos framework not only contributes to its biological activity but also poses intriguing questions regarding its synthetic pathways and stability.
  • Biological Significance: Compounds with similar structural features have been investigated for their therapeutic roles, especially in cancer treatment, due to their ability to interact with biological macromolecules.
  • Drug Delivery Potential: The tailored architecture could lead to advancements in drug delivery systems, allowing for better solubility and bioavailability of therapeutic agents.
  • Synthesis Challenges: The synthesis of such large and complex molecules often requires innovative methodologies, making it a challenging yet rewarding endeavor for chemists.

As one delves deeper into the chemistry behind this compound, it becomes evident that each aspect of its design could lead to significant breakthroughs in various fields such as pharmaceutical science and biochemistry. The exploration of similar compounds can inspire novel research directions and technological advancements, illustrating the ever-evolving landscape of chemical science.

Synonyms
Aerosporin
1404-26-8
Polymyxin B1-d3
Spectrum_001117
Spectrum2_000490
Spectrum3_000549
Spectrum4_000481
Spectrum5_001331
BSPBio_002197
KBioGR_000961
KBioSS_001597
DivK1c_000732
SPBio_000359
CHEMBL241797
SCHEMBL7799155
GTPL10338
KBio1_000732
KBio2_001597
KBio2_004165
KBio2_006733
KBio3_001697
NINDS_000732
WQVJHHACXVLGBL-UHFFFAOYSA-N
EAA13511
IDI1_000732
NCGC00178768-01
NCGC00178768-03
SBI-0051486.P003
AB00053527_02
BRD-A08641215-065-04-8