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Clonidine

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Identification
Molecular formula
C9H9Cl2IN2
CAS number
4205-91-8
IUPAC name
N-(2,6-dichloro-4-iodo-phenyl)-4,5-dihydro-1H-imidazol-2-amine
State
State

At room temperature, clonidine exists in solid state as a powder.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
266.56g/mol
Molar mass
230.0920g/mol
Density
1.7000g/cm3
Appearence

Clonidine typically appears as a white or off-white crystalline powder. It is practically insoluble in water but soluble in alcohol and chloroform.

Comment on solubility

Solubility of N-(2,6-dichloro-4-iodo-phenyl)-4,5-dihydro-1H-imidazol-2-amine

The solubility of N-(2,6-dichloro-4-iodo-phenyl)-4,5-dihydro-1H-imidazol-2-amine (C9H9Cl2IN2) presents intriguing characteristics due to its complex molecular structure. Understanding its solubility is essential in various applications, including drug formulation and material science.

The compound's solubility can be influenced by several factors:

  • Polarity: The presence of chlorine and iodine substituents introduces significant polarity, which may affect water solubility.
  • Hydrogen Bonding: Imidazole groups can participate in hydrogen bonding, potentially increasing solubility in polar solvents.
  • Temperature: As with many chemical compounds, increasing the temperature may enhance solubility, particularly in organic solvents.
  • pH Levels: The ionization state of the amine group can be altered by pH, influencing solubility in aqueous solutions.

Research shows that such compounds often exhibit low solubility in water but may be more soluble in organic solvents such as DMSO or ethanol. Thus, it is crucial to carry out solubility testing under different conditions to identify suitable solvent systems for practical applications. As noted in solubility studies, "*The right solvent can make all the difference.*"

In summary, while N-(2,6-dichloro-4-iodo-phenyl)-4,5-dihydro-1H-imidazol-2-amine may not be highly soluble in water, its solubility profile can be optimized depending on the chosen solvent and environmental factors.

Interesting facts

Interesting Facts about N-(2,6-Dichloro-4-Iodo-Phenyl)-4,5-Dihydro-1H-Imidazol-2-Amine

N-(2,6-dichloro-4-iodo-phenyl)-4,5-dihydro-1H-imidazol-2-amine is a fascinating compound worth exploring due to its unique structural features and potential applications in various fields. Here are some interesting insights:

  • Biological Relevance: This compound is part of a class of molecules that have exhibited significant antimicrobial and antineoplastic properties. Researchers are keen on understanding its mechanism of action against certain pathogens and cancer cells.
  • Structural Attributes: The presence of multiple halogens, specifically chlorine and iodine, contributes to the compound's chemical reactivity and stability. Such substituents can modify the electronic distribution, enhancing its biological activity.
  • Imidazole Ring: The imidazole moiety in its structure is noteworthy. Imidazoles are essential in many biological systems, acting as biologically active agents. This particular compound's imidazole ring can play a critical role in drug design.
  • Synthetic Pathways: Synthesis of this compound may involve various organic reactions, including halogenation and amination processes. Understanding these pathways can be pivotal in developing more effective synthetic routes.
  • Potential Uses: Beyond its biological implications, compounds like these are being studied for their potential applications in pharmaceuticals, agrochemicals, and materials science.

As we delve deeper into this compound's chemistry, it is intriguing to ponder its role and efficacy in medicinal chemistry. The interaction of such intricate molecular structures with biological systems remains a rich field for investigation.

Synonyms
p-Iodoclonidine
4-iodoclonidine
JJ25E6L8H3
CHEMBL360803
n-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1h-imidazol-2-amine
1H-Imidazol-2-amine, N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-
Lopac-I-114
UNII-JJ25E6L8H3
Lopac0_000664
SCHEMBL563884
SCHEMBL10606433
BDBM50021809
PDSP1_000181
PDSP2_000180
CCG-204750
SDCCGSBI-0050643.P002
NCGC00015530-01
NCGC00015530-02
NCGC00015530-03
NCGC00162217-01
(2,6-Dichloro-4-iodo-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine
(2,6-Dichloro-4-iodo-phenyl)-imidazolidin-2-ylidene-amine (p-iodoclonidine)