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Fluorodifen

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Identification
Molecular formula
C18H18F6N2O3
CAS number
154-56-5
IUPAC name
N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
State
State

At room temperature, Fluorodifen is a solid, typically found in a crystalline form. It is stable under normal conditions.

Melting point (Celsius)
65.60
Melting point (Kelvin)
338.75
Boiling point (Celsius)
403.80
Boiling point (Kelvin)
676.95
General information
Molecular weight
425.34g/mol
Molar mass
425.3400g/mol
Density
1.3372g/cm3
Appearence

Fluorodifen appears as a white to off-white crystalline solid. It is characterized by its aromatic benzamide structure with functional groups from the trifluoroethoxy and piperidylmethyl components.

Comment on solubility

Solubility of N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide, with the chemical formula C18H18F6N2O3, exhibits interesting solubility characteristics.

In general, the solubility of a compound can be influenced by various factors, including:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents.
  • Hydrophobic Regions: Conversely, hydrophobic segments can lead to decreased solubility in water.
  • Temperature: Increased temperature often increases solubility for many solids and liquids.

For this compound:

  • It likely demonstrates low to moderate solubility in water due to the hydrophobic fluorinated segments.
  • It may be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol, which can solubilize both polar and nonpolar characteristics.

As chemists often note, "like dissolves like," suggesting that this compound's solubility profile is influenced heavily by its unique chemical structure. Understanding these solubility properties is essential, especially in applications such as drug formulation and environmental chemistry.

Interesting facts

Interesting Facts about N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide is a fascinating chemical compound with a complex structure that lends itself to various applications in medicinal chemistry and material science.

Key Features

  • Biological Relevance: This compound features a piperidine ring, which is known for its biological activity. Compounds containing piperidine are often studied for their potential as therapeutic agents in treating various conditions, such as neurodegenerative diseases and psychiatric disorders.
  • Fluorinated Properties: The presence of multiple trifluoroethoxy groups enhances the chemical stability and lipophilicity of this compound, making it a point of interest for drug design. Fluorinated compounds can exhibit improved pharmacokinetic properties, increasing their efficacy and bioavailability.
  • Structure-Activity Relationship: The unique combination of the benzamide structure and the trifluoroethoxy moieties provides a rich landscape for exploring the structure-activity relationship (SAR). Scientists can modify different components to optimize potency and selectivity for specific biological targets.

Applications and Implications

The exploration of N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide goes beyond mere academic interest. Consider the following:

  • Drug Development: This compound serves as a potential lead for developing new pharmaceuticals targeting central nervous system disorders.
  • Research Tool: Its distinctive properties might be used as a research tool to study the effects of fluorination on biological interactions.
  • Material Science: The fluorinated ethoxy groups make it desirable in creating advanced materials with specific surface properties in fields such as coatings and polymers.

In summary, N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide is an intriguing compound with significant implications in both biological and material sciences. Its multifaceted structure invites ongoing research and application in a variety of innovative fields.

Synonyms
flecainide
54143-55-4
Flecaine
N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Flecainida
Tambocor
Flecainidum
(+-)-Flecainide
Flecainidum [INN-Latin]
Flecainida [INN-Spanish]
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
CCRIS 313
Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-
Flecainide (INN)
NSC-719273
UNII-K94FTS1806
DTXSID8023054
CHEBI:75984
K94FTS1806
MFCD00864713
THN-102 COMPONENT FLECAINIDE
CHEMBL652
N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
DTXCID403054
THN102 COMPONENT FLECAINIDE
NSC 719273
NCGC00015443-06
FLECAINIDE [INN]
Flecainidum (INN-Latin)
N-[(piperidin-2-yl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Flecainida (INN-Spanish)
Flecainide [INN:BAN]
C17H20F6N2O3
CAS-54143-55-4
(+/-)-flecainide
NSC719273
rac-Flecainide
Flecainide (Standard)
FLECAINIDE [MI]
Prestwick0_000735
Prestwick1_000735
Prestwick2_000735
Prestwick3_000735
FLECAINIDE [VANDF]
FLECAINIDE [WHO-DD]
Lopac0_000546
SCHEMBL14970
BSPBio_000690
BSPBio_001317
KBioGR_000037
KBioSS_000037
SPBio_002629
BPBio1_000760
GTPL2560
BCBcMAP01_000189
KBio2_000037
KBio2_002605
KBio2_005173
KBio3_000073
KBio3_000074
C01BC04
Bio1_000375
Bio1_000864
Bio1_001353
Bio2_000037
Bio2_000517
HMS1791B19
HMS1989B19
HMS2089E17
BCP24373
HY-W010950R
Tox21_110151
BDBM50131434
N-(piperidin-2-ylmethyl)-2,5-bis[(2,2,2-trifluoroethyl)oxy]benzamide
NSC782306
AKOS015962192
Tox21_110151_1
CCG-204636
CS-W011666
DB01195
FF27520
HY-W010950
NSC-782306
SB19141
IDI1_033787
SMP1_000074
NCGC00015443-04
NCGC00015443-05
NCGC00015443-07
NCGC00015443-08
NCGC00015443-10
NCGC00015443-11
NCGC00015443-12
NCGC00015443-13
NCGC00015443-14
NCGC00015443-15
NCGC00015443-17
NCGC00025175-03
NCGC00025175-04
NCGC00025175-05
NCGC00025175-06
AC-16019
AC-31101
AS-71745
SY269348
DB-052496
DB-230917
AB00513907
NS00010512
C07001
D07962
EN300-144572
F18100
AB00384356-13
Q421381
BRD-A09472452-001-02-8
BRD-A09472452-015-03-6
BRD-A09472452-015-11-9
BRD-A09472452-015-22-6
BRD-A09472452-015-23-4
2,5-bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide
2,5-bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide #
N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide
N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide (Flecainide)
N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide(Flecainide)
N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide(Flecanide)