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Acetamidine

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Identification
Molecular formula
C11H13NO3
CAS number
104-66-5
IUPAC name
N-(2-methoxyphenyl)-3-oxo-butanamide
State
State

At room temperature, this compound appears typically as a solid.

Melting point (Celsius)
24.50
Melting point (Kelvin)
297.65
Boiling point (Celsius)
362.00
Boiling point (Kelvin)
635.15
General information
Molecular weight
191.23g/mol
Molar mass
151.1730g/mol
Density
1.1445g/cm3
Appearence

The compound is typically a crystalline solid with a color that can range from white to off-white.

Comment on solubility

Solubility of N-(2-methoxyphenyl)-3-oxo-butanamide

N-(2-methoxyphenyl)-3-oxo-butanamide exhibits intriguing solubility characteristics, which are influenced by its molecular structure. Understanding its solubility can provide valuable insights into its behavior in various solvents, both polar and non-polar.

  • Polar Solvents: This compound is likely to be soluble in polar solvents such as water and dimethyl sulfoxide (DMSO), owing to the presence of the amide functional group that can engage in hydrogen bonding.
  • Non-Polar Solvents: Conversely, in non-polar solvents like hexane or toluene, the solubility may decrease significantly. This is primarily due to the limited interaction between the non-polar solvent molecules and the polar regions of the compound.

It is noteworthy to mention that solubility can also be affected by factors such as:

  1. Temperature: Increasing temperature can enhance solubility in many solvents.
  2. pH: Modifications in pH can change the ionization of the amide group, possibly altering solubility.
  3. Concentration: A saturated solution may exhibit different properties compared to dilute solutions.

In conclusion, while N-(2-methoxyphenyl)-3-oxo-butanamide may be soluble in a range of solvents, its solubility profile is largely dependent on environmental conditions and the nature of the solvent used. Understanding these interactions can help in effectively utilizing the compound in various applications.

Interesting facts

Interesting Facts about N-(2-methoxyphenyl)-3-oxo-butanamide

N-(2-methoxyphenyl)-3-oxo-butanamide, often referred to as a derivative of butanamide, is a compound that stands out in the field of organic chemistry. Here are some intriguing aspects of this chemical:

  • Versatile Functionality: This compound contains both an amide group and a ketone, making it a versatile intermediate for synthesizing other organic compounds. Its structure allows for a variety of reactions including acylation and condensation.
  • Applications in Pharmaceuticals: It is explored in pharmaceutical research due to its potential biological activity. Compounds with similar structural features have been investigated for their anti-inflammatory and analgesic properties.
  • Research Interest: Researchers are particularly interested in the effect of the methoxy group on the pharmacokinetics and pharmacodynamics of the compound, providing insights into how small structural changes can influence biological activity.
  • Synthetic Pathways: The synthesis of N-(2-methoxyphenyl)-3-oxo-butanamide typically involves the reaction of butyric acid derivatives with amines or phenols. This highlights its relevance in teaching synthetic organic chemistry in academic settings.
  • Analytical Techniques: This compound can be characterized by various analytical techniques such as NMR and IR spectroscopy, which are essential for confirming structure in organic chemistry labs.

In conclusion, N-(2-methoxyphenyl)-3-oxo-butanamide is not merely a compound; it serves as a gateway into understanding more complex chemical behaviors and applications in medicinal chemistry. As one researcher aptly put it, "The beauty of organic compounds lies in their ability to unveil the hidden potential of even the simplest structures."


Synonyms
N-(2-Methoxyphenyl)-3-oxobutanamide
92-15-9
O-ACETOACETANISIDIDE
o-Acetoacetaniside
Acetoacet-o-anisidide
N-Acetoacetyl-o-anisidine
Acetoacetyl-o-anisidine
2'-Methoxyacetoacetanilide
Acetoacetyl-o-anisidide
o-Methoxyacetoacetanilide
2-Acetoacetylaminoanisole
Acetoacetic acid o-anisidide
Butanamide, N-(2-methoxyphenyl)-3-oxo-
2-Methoxyacetoacetanilide
Acetoacet-o-anisidin
o-Anisidine, acetoactyl-
Acetoacetyl-o-aniside
1-Acetoacetylamino-2-methoxybenzene
o-Anisidine, acetoacetyl-
NSC 7563
Acetoacet-2-anisidide
Acetoacet-o-anisidin [Czech]
2-Methoxyanilid kyseliny acetoctove
EINECS 202-131-0
6VBR220ROM
BRN 1459707
acetoaceto-o-anisidide
DTXSID9026558
Acetoacetic acid 2-methoxyanilide
AI3-04822
2-Methoxyanilid kyseliny acetoctove [Czech]
NSC-7563
DTXCID306558
KYYRTDXOHQYZPO-UHFFFAOYSA-
EC 202-131-0
2-(ACETOACETYLAMINO)ANISOLE
ACETOACETIC ACID 2-ANISIDIDE
N-(2-METHOXYPHENYL)ACETOACETAMIDE
CAS-92-15-9
Acetoacetyl-o-acetanisidine
UNII-6VBR220ROM
N-Acetoacetyl-2-methoxyaniline
MFCD00008781
Acetoacetyl-o-anisine
o-Acetoacetanisidide (8CI)
WLN: 1V1VMR BO1
SCHEMBL54737
CHEMBL1873009
NSC7563
Tox21_201280
Tox21_303221
STK398095
AKOS000120109
CS-W015272
N-(2-Methoxy-phenyl)-3-oxo-butyramide
N-(2-Methoxyphenyl)-3-oxobutanamide #
NCGC00164212-01
NCGC00164212-02
NCGC00257148-01
NCGC00258832-01
AS-15272
DB-057292
A1306
NS00008374
EN300-17429
D78239
AB00079700-01
SR-01000203739
SR-01000203739-1
Q27265584
Z56931787
F3189-0142
202-131-0