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Paracetamol

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Identification
Molecular formula
C8H9NO2
CAS number
103-90-2
IUPAC name
N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
State
State

At room temperature, paracetamol is in a solid state. It is typically encountered in powdered form or as tablets for medicinal use.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
387.00
Boiling point (Kelvin)
660.15
General information
Molecular weight
151.17g/mol
Molar mass
151.1650g/mol
Density
1.2630g/cm3
Appearence

Paracetamol is typically in the form of a white, crystalline solid. It can also appear as a powder and is commonly available in tablet or capsule form for use as a medication.

Comment on solubility

Solubility of N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

The solubility of the compound N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide (C8H9NO2) presents interesting characteristics due to its unique structural features.

Factors Influencing Solubility

When considering the solubility of this compound, it's essential to take into account the following factors:

  • Hydrogen Bonding: The presence of hydroxyl groups can facilitate hydrogen bonding with solvents, particularly in polar solvents like water.
  • Polarity: The balance between polar and non-polar regions affects how well the compound dissolves in various solvents. Its nitrophenyl group adds some polarity, making it more soluble in organic solvents.
  • Temperature: Solubility typically increases with temperature, and this compound may demonstrate enhanced solubility in warmer conditions.

General Observations

In general, compounds similar to C8H9NO2 exhibit variable solubility:

  • Often soluble in dimethyl sulfoxide (DMSO) and other polar organic solvents.
  • Potential moderate solubility in water due to its hydroxyl groups.
  • May form stable solutions at various pH levels, depending on the ionization of functional groups.

Understanding the solubility of this compound is crucial for applications in pharmaceuticals and chemistry. A thoughtful consideration of these factors can guide researchers in effectively utilizing this compound in various formulations.

Interesting facts

Interesting Facts about N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide is a compelling compound with diverse implications in various scientific fields. Here are some insightful aspects worth noting:

  • Pharmaceutical Relevance: This compound has garnered attention in medicinal chemistry due to its potential as a drug candidate, particularly in the development of anti-cancer agents. The presence of the nitrophenyl group suggests potential interactions with biological targets.
  • Structure-Activity Relationship (SAR): The intricate structure combining hydroxymethyl and nitrophenyl moieties enables researchers to study SAR, leading to a deeper understanding of how chemical modifications influence biological activity.
  • Analytical Techniques: The compound can be characterized using various analytical techniques, including Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS), which are vital in verifying its structure and purity in research applications.
  • Environmental Impact: Understanding the stability and degradation of such compounds is crucial. Researchers often study their environmental impact to ensure that they do not pose risks when used in pharmaceuticals.
  • Research Potential: Ongoing studies are focusing on the modification of this compound to enhance its efficacy and reduce side effects, making it a fertile ground for advanced research.

As a student or enthusiast in chemistry, you might find the chemical synthesis of this compound fascinating, opening doors to creative approaches in molecular design. Exploring its properties and functionalities can lead to numerous discoveries, contributing to both academic learning and practical applications in health and safety.

Synonyms
n-acetyl-p-nitrophenylserinol
N-Acetyl-4-nitrophenylserinol
Corynecin I
15376-53-1
4618-99-9
n-[1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
NSC 48738
GNF-PF-3018
Acetamide, N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-
NCIOpen2_002798
Oprea1_779552
CBDivE_000863
CHEMBL280196
SCHEMBL8121625
DTXSID70864590
CHEBI:201511
D,L-2-ACETAMIDO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
NSC48738
NSC-48738
AKOS023249379
NS00047288
N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl] acetamide