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Brompheniramine

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Identification
Molecular formula
C16H19BrClN
CAS number
86-22-6
IUPAC name
N-[(2-bromophenyl)methyl]-2-chloro-N-ethyl-ethanamine
State
State

At room temperature, brompheniramine is a solid. It is commonly used as an antihistamine in medication formulations.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
309.30
Boiling point (Kelvin)
582.45
General information
Molecular weight
319.69g/mol
Molar mass
319.6560g/mol
Density
1.3300g/cm3
Appearence

Brompheniramine is typically found as a white to off-white crystalline powder. It is often odorless and has a slightly bitter taste.

Comment on solubility

Solubility of N-[(2-bromophenyl)methyl]-2-chloro-N-ethyl-ethanamine

The compound N-[(2-bromophenyl)methyl]-2-chloro-N-ethyl-ethanamine (C16H19BrClN) exhibits a solubility profile that can be influenced by several key factors. Understanding the solubility of such organic compounds is crucial for practical applications in pharmaceuticals, agrochemicals, and industrial chemistry. Here are important points to consider:

  • Polarity: The presence of multiple functional groups, including the halogen atoms (Br and Cl), contributes to the compound's polar characteristics. This results in a moderate solubility in polar solvents like water.
  • Hydrophobic interactions: The aromatic bromophenyl group tends to create hydrophobic interactions, making the compound more soluble in non-polar solvents, such as hexane or toluene.
  • Temperature dependence: Solubility can vary significantly with temperature changes; typically, higher temperatures increase solubility for solids.
  • pH effects: As an amine, the compound's solubility can be affected by the pH of the solution, with increased solubility in acidic conditions due to protonation.

In summary, understanding the solubility of N-[(2-bromophenyl)methyl]-2-chloro-N-ethyl-ethanamine necessitates a comprehensive analysis of its chemical structure and the interactions with various solvents. It is essential to conduct solubility tests under controlled conditions to obtain precise values for practical applications.

Interesting facts

Exploring N-[(2-bromophenyl)methyl]-2-chloro-N-ethyl-ethanamine

N-[(2-bromophenyl)methyl]-2-chloro-N-ethyl-ethanamine is a fascinating compound that showcases the intricate relationships between structure and function in organic chemistry. Here are some interesting facts about this compound:

  • Pharmacological Relevance: This compound belongs to a class of molecules that can exhibit significant biological activity. Research into compounds like this often seeks to understand their potential uses in pharmacology, particularly as drug candidates.
  • Structural Highlights: The presence of a bromine atom and a chlorine atom introduces unique reactivity patterns, making this compound an interesting subject for studies on substitution reactions and mechanisms.
  • Potential Applications: Compounds containing amine functionalities, like this one, are often utilized as intermediates in the synthesis of more complex drugs, agrochemicals, and other functional materials.
  • Physical Chemistry Considerations: The halogen substitutions (bromine and chlorine) may influence the compound’s electronic properties and hydrogen bonding capabilities, which can affect its interactions with biological targets.
  • Isomerism: The potential for stereoisomerism in such compounds can lead to different properties and biological effects. This points to the importance of chirality in medicinal chemistry.

In summary, N-[(2-bromophenyl)methyl]-2-chloro-N-ethyl-ethanamine is more than just a collection of atoms; it represents a gateway into the world of medicinal chemistry, reactivity, and the continuous exploration of chemical compounds in pursuit of new therapeutic agents. The insights gained from studying such compounds can significantly influence future developments in both chemistry and pharmaceuticals.

Synonyms
DSP 4
62078-98-2
az-Dsp 4
n-(2-bromobenzyl)-2-chloro-n-ethylethanamine
Benzenemethanamine, 2-bromo-N-(2-chloroethyl)-N-ethyl-
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine
UNII-PQ1P7JP5C1
2-Bromo-N-(2-chloroethyl)-N-ethylbenzenemethanamine
PQ1P7JP5C1
DTXSID50211124
N-(2-Bromobenzyl)-2-chloro-N-ethylethan-1-amine
N-[(2-bromophenyl)methyl]-2-chloro-N-ethylethanamine
starbld0002529
Lopac-C-8417
Lopac0_000299
SCHEMBL693529
CHEMBL1334976
DTXCID50133615
AKOS009158150
CCG-204394
SDCCGSBI-0050287.P002
NCGC00015276-01
NCGC00015276-02
NCGC00015276-03
NCGC00162121-01
NS00075455
Q5206163