Acarbose | Solubility of Things

Identification

Molecular formula

C₂₅H₄₃NO₁₈

CAS number

56180-94-0

IUPAC name

N-[2-[5-[3-acetamido-6-[4,5-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-6-[[17-(1,5-dimethyl-3-oxo-hex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-tetrahydropyran-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide

State

Solid at room temperature, typically in the form of a white to off-white powder.

Melting point (Celsius)

159.50

Melting point (Kelvin)

432.70

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

645.61g/mol

Molar mass

645.6080g/mol

Density

1.2800g/cm³

Appearence

Acarbose is typically a white to off-white powder. It is odorless or has a very faint characteristic smell.

Comment on solubility

Solubility of N-[2-[5-[3-acetamido-6-[4,5-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-6-[[17-(1,5-dimethyl-3-oxo-hex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-tetrahydropyran-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide

The solubility of N-[2-[5-[3-acetamido-6-[4,5-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-6-[[17-(1,5-dimethyl-3-oxo-hex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-tetrahydropyran-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (C₂₅H₄₃NO₁₈) is influenced by its complex structure, which incorporates multiple hydroxyl (-OH) groups. This characteristic typically enhances solubility in polar solvents such as water. Here are some general insights regarding its solubility:

Hydroxyl Groups: The presence of multiple hydroxyl groups increases hydrogen bonding with water, enhancing solubility.
Structural Complexity: The large molecular size and intricate structure may lead to variations in solubility based on solution concentration.
Polarity: As a polar compound, it likely exhibits significant solubility in aqueous environments compared to nonpolar solvents.
Temperature Dependence: Solubility may also vary with temperature; increased temperatures often promote greater solubility for many compounds.

In summary, while it is reasonable to expect N-[2-[5-[3-acetamido-6-[4,5-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-6-[[17-(1,5-dimethyl-3-oxo-hex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-tetrahydropyran-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide to be soluble in water, precise solubility characteristics should ideally be determined through experimental assessments for definitive conclusions.

Interesting facts

Interesting Facts about N-[2-[5-[3-Acetamido-6-[4,5-Dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-6-[[17-(1,5-Dimethyl-3-oxo-hex-4-enyl)-4,4,10,13,14-Pentamethyl-2,3,5,6,7,8,12,15,16,17-Decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-tetrahydropyran-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide

This compound is a fascinating example of complexity in organic chemistry, largely due to its intricate structure involving multiple functional groups and sugar moieties. Here are some interesting insights:

Structural Complexity: The compound contains multiple tetrahydropyran rings and hydroxyl groups, which enhance its potential bioactivity and solubility in biological environments.
Biological Significance: Compounds like this one are often investigated for their applications in medicinal chemistry, potentially serving as drugs or therapeutic agents due to their structural similarity to naturally occurring biomolecules.
Natural Source: The presence of sugar-like structures suggests that this compound might be involved in important biochemical pathways, possibly mimicking the action of polysaccharides found in nature.
Potential Research Applications: Its complexity makes it a subject of interest in various fields such as organic synthesis, pharmacology, and even materials science.

In summary, this compound exemplifies the beauty and complexity of chemical structures, reflecting ongoing efforts to understand how molecular architecture can influence biological activity. As scientists delve deeper into the study of such compounds, we may unlock new therapeutic potentials and enhance our understanding of molecular interactions in biological systems.