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Afatinib

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Identification
Molecular formula
C24H25ClFN5O3
CAS number
850140-73-7
IUPAC name
N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenyl-prop-2-enamide;hydrochloride
State
State

At room temperature, Afatinib hydrochloride is typically in a solid state, often supplied as a crystalline powder for medical or research purposes.

Melting point (Celsius)
142.90
Melting point (Kelvin)
416.00
Boiling point (Celsius)
431.80
Boiling point (Kelvin)
705.00
General information
Molecular weight
718.56g/mol
Molar mass
718.5590g/mol
Density
1.5093g/cm3
Appearence

Afatinib hydrochloride typically appears as a white to slightly yellowish or beige crystalline powder. It is often provided in a solid form for pharmaceutical applications.

Comment on solubility

Solubility of N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenyl-prop-2-enamide; hydrochloride

The solubility of the compound N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenyl-prop-2-enamide; hydrochloride (C24H25ClFN5O3) can be influenced by several factors. Understanding these factors is essential for applications in pharmaceuticals and materials chemistry.

  • Polarity: The presence of the hydrochloride salt form generally increases solubility in polar solvents, particularly water.
  • pH Level: The solubility may vary with the pH of the solution. Acidic environments can enhance solubility for compounds with basic groups.
  • Temperature: Typically, solubility increases with temperature. Therefore, heating the solution may improve dissolution rates.
  • Solvent Type: The choice of solvent impacts solubility. The compound may demonstrate higher solubility in organic solvents like ethanol compared to non-polar solvents.

In summary, while solubility is a complex property influenced by various physical and chemical factors, the hydrochloride salt of this compound is likely to exhibit favorable solubility characteristics in aqueous solutions. As with many pharmaceuticals, exploring different formulations can also affect its bioavailability.

Interesting facts

Interesting Facts about N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenyl-prop-2-enamide; hydrochloride

This compound, often referred to in the scientific community, showcases a fascinating blend of organic chemistry and medicinal applications. Here are some insightful facts about it:

  • Unique Structure: The compound features a complex molecular structure that includes a phenyl group, a prop-2-enamide moiety, and a sulfanyl group. This unique combination can contribute to various biological activities.
  • Biological Activity: Compounds with similar structural motifs are often studied for their potential therapeutic effects, particularly in fields such as pharmacology and medicinal chemistry.
  • Dimethylamino Group: The presence of a dimethylamino group is significant, as it can enhance the compound's solubility and permeability, traits crucial for drug design and delivery.
  • Research Applications: This compound may have implications in research areas focused on neuropharmacology and other domains where understanding the interaction of such compounds with biological systems is important.
  • Hydrochloride Salt Form: The hydrochloride form indicates improved stability and solubility properties, which are often advantageous for pharmaceutical formulations.

In summary, N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenyl-prop-2-enamide; hydrochloride is not just another chemical compound; it is a potential cornerstone for ongoing research in the realms of medicinal chemistry and drug development.

Synonyms
LXGJPDKYMJJWRB-UHFFFAOYSA-N
D80615
2'-(3-dimethylaminopropylthio) cinnamanilide hydrochloride
2'-(3-Dimethylaminopropylthio)cinnamanilide, hydrochloride