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H-89

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Identification
Molecular formula
C20H24BrN3O3S
CAS number
130964-39-5
IUPAC name
N-[2-[3-(4-bromophenyl)allylamino]ethyl]isoquinoline-5-sulfonamide
State
State

At room temperature, H-89 is typically in a solid state. It is commonly provided in its hydrochloride salt form to enhance stability and solubility for laboratory use.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.20
Boiling point (Celsius)
506.40
Boiling point (Kelvin)
779.60
General information
Molecular weight
458.40g/mol
Molar mass
488.3540g/mol
Density
1.4500g/cm3
Appearence

H-89 typically appears as a yellowish to off-white powder. It should be handled in a dry environment and stored away from light to prevent any degradation that may affect its appearance and efficacy.

Comment on solubility

Solubility of N-[2-[3-(4-bromophenyl)allylamino]ethyl]isoquinoline-5-sulfonamide (C20H24BrN3O3S)

The solubility of N-[2-[3-(4-bromophenyl)allylamino]ethyl]isoquinoline-5-sulfonamide is influenced by various factors such as temperature, the solvent system used, and the chemical nature of the compound itself. This compound, being a sulfonamide, suggests certain solubility characteristics:

  • Polarity: With sulfonamide functional groups, this compound may exhibit moderate to high polarity, enhancing solubility in polar solvents like water and dimethyl sulfoxide (DMSO).
  • Hydrogen Bonding: The presence of nitrogen and sulfonyl groups can facilitate hydrogen bonding, which may improve its solubility in aqueous solutions.
  • Organic Solvents: It may show varied solubility in organic solvents, typically being more soluble in polar organic solvents compared to non-polar solvents.
  • Temperature Dependence: An increase in temperature generally enhances the solubility of organic compounds, hence this sulfonamide might dissolve better at elevated temperatures.

Overall, while the solubility of this compound can be expected to be relatively good in polar solvents, its behavior in non-polar environments may reflect limited solubility. As with all chemical compounds, specific experimental conditions should be explored to determine the solubility profile accurately.

Interesting facts

Interesting Facts about N-[2-[3-(4-bromophenyl)allylamino]ethyl]isoquinoline-5-sulfonamide

N-[2-[3-(4-bromophenyl)allylamino]ethyl]isoquinoline-5-sulfonamide is an intriguing compound within the field of organic chemistry, particularly in medicinal chemistry. Here are some fascinating insights about this compound:

  • Pharmaceutical Relevance: This compound belongs to a class of sulfonamides, which are known for their diverse therapeutic applications. They have been utilized as antibiotics and are being explored for their potential in cancer treatment.
  • Structural Complexity: The compound features a multi-functional structure that includes both isoquinoline and sulfonamide moieties. This complexity can enhance its biological activity and specificity.
  • Bridging Two Worlds: The presence of a bromophenyl group indicates potential for various substitution reactions, allowing chemists to modify the compound for improved efficacy.
  • Mechanism of Action: Sulfonamides generally work by inhibiting bacterial synthesis of folic acid, which is crucial for their growth. Understanding this mechanism is essential for developing new drugs with minimized resistance.
  • Research Applications: Ongoing studies often explore the potential of isoquinoline derivatives in treating conditions like neurodegenerative diseases, demonstrating the compound's importance beyond antibiotics.

In summary, N-[2-[3-(4-bromophenyl)allylamino]ethyl]isoquinoline-5-sulfonamide exemplifies the intersection of structure and function in medicinal chemistry. Its unique composition and potential therapeutic applications make it a subject of continuous interest and research in scientific communities.

Synonyms
N-[2-[3-(4-bromophenyl)prop-2-enylamino]ethyl]isoquinoline-5-sulfonamide
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
CHEBI:47495
Kinome_2783
CBiol_002015
KBioGR_000447
KBioSS_000447
CHEMBL1987756
KBio2_000447
KBio2_003015
KBio2_005583
KBio3_000833
KBio3_000834
N-(2-{[3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide
Bio1_000301
Bio1_000790
Bio1_001279
Bio2_000384
Bio2_000864
HMS3673M11
HMS3745E05
SB19596
NCGC00162073-05
n-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulphonamide