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Bumetanide

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Identification
Molecular formula
C17H20N2O5S
CAS number
28395-03-1
IUPAC name
N-[2-[2-[2-[(2-amino-3-phenyl-propanoyl)amino]ethoxy]ethoxy]ethyl]-4-sulfamoyl-benzamide
State
State
Bumetanide is typically a solid at room temperature.
Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
372.40
Boiling point (Kelvin)
645.55
General information
Molecular weight
364.42g/mol
Molar mass
364.4170g/mol
Density
1.0500g/cm3
Appearence
Bumetanide usually appears as a white to off-white crystalline powder.
Comment on solubility

Solubility of N-[2-[2-[2-[(2-amino-3-phenyl-propanoyl)amino]ethoxy]ethoxy]ethyl]-4-sulfamoyl-benzamide

The solubility of the compound N-[2-[2-[2-[(2-amino-3-phenyl-propanoyl)amino]ethoxy]ethoxy]ethyl]-4-sulfamoyl-benzamide, with the chemical formula C17H20N2O5S, can be quite intriguing, given its complex structure.

  • Hydrophilicity vs. Hydrophobicity: This compound contains multiple functional groups, including sulfamoyl and amino groups, which can enhance its solubility in polar solvents.
  • Polar Functional Groups: The presence of ethoxy chains and the sulfonamide moiety typically contribute to an increased affinity for water, promoting solubility in aqueous solutions.
  • Temperature Dependence: As with many compounds, solubility may vary significantly with temperature, often increasing at elevated temperatures.
  • pH Influence: The solubility may also be influenced by the pH of the solution, given the amino and sulfonamide groups' potential to ionize and interact with protons.

In summary, while the potential for solubility is high due to its various polar amine and sulfonamide groups, the exact solubility will depend on specific conditions such as temperature, pH, and solvent composition. Thus, experimental determination in relevant solvents is essential to ascertain the true solubility characteristics of this compound.

Interesting facts

N-[2-[2-[2-[(2-amino-3-phenyl-propanoyl)amino]ethoxy]ethoxy]ethyl]-4-sulfamoyl-benzamide

This compound is a fascinating example of a sulfonamide derivative, known for its ability to mimic natural substrates and its role in various biological systems. Here are some intriguing aspects to consider:

  • Medicinal Chemistry: Compounds like this are often studied for their potential therapeutic applications. Sulfonamides are commonly recognized for their antibiotic properties, paving the way for treatments against bacterial infections.
  • Structural Features: The presence of multiple ethoxy groups in the structure suggests intriguing interactions with biological membranes, which can enhance the compound's bioavailability.
  • Pharmacophore Innovations: The incorporation of an amino acid derivative (in this case, 2-amino-3-phenyl-propanoyl) highlights the compound's potential to act as a lead scaffold for the design of novel drugs targeting specific enzymes or receptors. This is crucial in drug design as it promotes selectivity and reduces side effects.
  • Biological Activities: Research suggests that such compounds can exhibit a range of pharmacological activities beyond antibacterial effects, including anti-inflammatory and antitumor properties. Their study remains vital in the search for multifunctional agents in modern medicine.

As we delve deeper into the world of medicinal chemistry, compounds like N-[2-[2-[2-[(2-amino-3-phenyl-propanoyl)amino]ethoxy]ethoxy]ethyl]-4-sulfamoyl-benzamide serve as reminders of the intricate relationship between structure and function. As the renowned chemist Linus Pauling once said, "The nature of a chemical bond is a topic which is both scientifically important and philosophically fascinating." Indeed, the study of such compounds continues to unveil the secrets of chemistry and its potential to impact human health.

Synonyms
PD038195