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Atorvastatin

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Identification
Molecular formula
C33H35FN2O5
CAS number
134523-00-5
IUPAC name
N-[1-benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-pentyl]-3-methyl-2-(2-oxohexahydropyrimidin-1-yl)butanamide
State
State

Atorvastatin is commonly encountered as a solid under standard conditions (room temperature). The solid state facilitates its distribution and packaging, primarily in the form of tablets or capsules.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
710.00
Boiling point (Kelvin)
983.15
General information
Molecular weight
558.64g/mol
Molar mass
1 209.4160g/mol
Density
1.0925g/cm3
Appearence

Atorvastatin is a white to off-white crystalline powder. The compound is odourless, and the powder form allows it to be easily processed into tablet form for medical applications.

Comment on solubility

Solubility of N-[1-benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-pentyl]-3-methyl-2-(2-oxohexahydropyrimidin-1-yl)butanamide

The solubility of N-[1-benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-pentyl]-3-methyl-2-(2-oxohexahydropyrimidin-1-yl)butanamide, with the chemical formula C33H35FN2O5, is an interesting topic due to its complex molecular structure. This compound contains multiple functional groups that influence its solubility in various solvents. Generally, the solubility can be assessed based on the following factors:

  • Polarity: The presence of polar groups or functional groups like amides and hydroxyl can enhance solubility in polar solvents like water.
  • Hydrophobic Character: The bulky aromatic and aliphatic hydrocarbon portions of the molecule may impart hydrophobic characteristics, making it less soluble in polar solvents.
  • Temperature Dependency: Like many organic compounds, solubility may increase with temperature, highlighting the importance of conducting studies at varying thermal conditions.
  • pH Effects: The ionization of certain functional groups can be influenced by the pH of the solvent, potentially affecting solubility significantly.

Although specific solubility data may not be readily available, compounds of similar structures often exhibit variable solubility. It is essential to conduct empirical testing to determine the exact solubility in practical applications. The complex nature of this compound suggests it may have limited solubility in aqueous solutions while potentially being more soluble in organic solvents.

Interesting facts

Interesting Facts about N-[1-benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-pentyl]-3-methyl-2-(2-oxohexahydropyrimidin-1-yl)butanamide

This compound represents a fascinating area of study in medicinal chemistry, given its complex structure and potential pharmacological applications. Here are some interesting insights:

  • Versatile Structure: The compound features a unique combination of multiple functional groups, including amides, phenyl rings, and hydroxyls, which may enable interactions with various biological targets.
  • Targeted Therapeutics: Compounds with such intricacies often find applications in drug development, particularly for targeting specific receptors or enzymes, thus providing a **potential pathway for therapeutic innovations**.
  • Synthetic Challenges: The synthesis of this compound could pose significant challenges due to its multi-step synthetic route. Such complexity can lead to fascinating *problems in stereochemistry and regioselectivity*, which are crucial in drug development.
  • Influence on Biological Activity: The presence of a dimethylphenoxy group suggests the possibility of enhanced lipophilicity, which might improve cellular penetration—an important factor for biological efficacy.
  • Research Opportunities: Ongoing research into related compounds could yield insights into new therapeutic agents, especially in areas such as oncology, where precision and targeting are paramount.

As you can see, this compound reflects the intriguing world of **chemical synthesis** and **biological interactions**. The potential implications for medicine make it a subject of great interest for scientists and students alike.

Synonyms
(2R,4S,5S)-Lopinavir
N-[5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
1217628-64-2
MFCD22628840
SCHEMBL8171504
HMS3654D21
BCP01395
XCC62554
NSC740137
AKOS032960319
NSC-740137
NCGC00389393-01
CID 71749833
LS-15397
SY073885
ABT-378;ABT 378;ABT378 pound>>A 157378.0 pound>>A-157378.0 pound>>A157378.0
(2s)-n-[(2s,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
2649902-54-3
N-(5-(2-(2,6-Dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
N-[1-benzyl-4-[2-(2,6-dimethylphenoxy)acetyl]amino-3-hydroxy-5-phenyl-pentyl]-3-methyl-2-(2-oxohexahydropyrimidin-1-yl)-butanamide