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Ambrisentan

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Identification
Molecular formula
C22H22N2O4S
CAS number
177036-94-1
IUPAC name
N-[1-[(4-carbamimidoylphenyl)methyl]-2-oxo-2-(1-piperidyl)ethyl]-2-(2-naphthylsulfonylamino)acetamide
State
State

At room temperature, Ambrisentan is typically found in a solid state.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.00
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.00
General information
Molecular weight
493.59g/mol
Molar mass
493.5850g/mol
Density
1.4300g/cm3
Appearence

Ambrisentan appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[1-[(4-carbamimidoylphenyl)methyl]-2-oxo-2-(1-piperidyl)ethyl]-2-(2-naphthylsulfonylamino)acetamide (C22H22N2O4S)

The solubility of this complex compound is influenced by several factors, given its unique functional groups and structure. Here are some insights:

  • Polarity: The presence of various functional groups such as the sulfonyl, amide, and amine can create a more polar environment, which may enhance solubility in polar solvents, particularly water.
  • Hydrophobic Areas: The naphthyl group indicates a hydrophobic region, suggesting that the compound may have limited solubility in polar solvents and might prefer non-polar organic solvents for dissolution.
  • pH Dependence: Being a compound with amine functionalities, solubility could also vary with changes in pH, influencing ionization and hence altering solubility characteristics.
  • Temperature Factor: Increased temperatures generally favor solubility; hence, this compound may exhibit better solubility at elevated temperatures.

In summary, while this compound showcases a potential for solubility in aqueous solutions due to its polar characteristics, its overall solubility profile is likely to be complex and variable depending on the solvent environment and external conditions. As a guiding principle: "A compound's solubility is a dance between its polar and non-polar characteristics, influenced by the surrounding milieu."
Further experimental data would be necessary to characterize the precise solubility in different solvents comprehensively.

Interesting facts

Interesting Facts about N-[1-[(4-carbamimidoylphenyl)methyl]-2-oxo-2-(1-piperidyl)ethyl]-2-(2-naphthylsulfonylamino)acetamide

This compound showcases a unique structure that combines a range of functional groups, which contribute to its intriguing properties and potential applications. Here are some compelling insights:

  • Pharmacological Significance: This compound has been studied for its potential as a pharmaceutical agent, particularly due to its interaction with biological targets.
  • Diverse Functional Groups: The structure features various functional moieties including sulfonamides and amides, which are known for their diverse biological activities.
  • Piperidine Structure: The presence of a piperidine ring introduces specific steric and electronic properties that can enhance the compound's reactivity and binding affinity in biological systems.
  • Research Potential: Compounds like this one are often subject to investigation in drug development, particularly for conditions requiring tailored medicinal chemistry approaches.
  • Structural Complexity: The complexity of the compound is impressive, making it a subject of interest for chemists studying synthesis and functionalization of multi-functional molecules.

As stated in a recent journal publication, “the intricate balance of hydrophilic and hydrophobic characteristics in such compounds fosters unique therapeutic applications.”
This highlights the importance of understanding each component of the molecular structure, as they often dictate the efficacy and safety of the potential drug.

In summary, N-[1-[(4-carbamimidoylphenyl)methyl]-2-oxo-2-(1-piperidyl)ethyl]-2-(2-naphthylsulfonylamino)acetamide stands as a promising compound in the field of medicinal chemistry, combining complexity with biological potential.

Synonyms
Thromstop
86125-48-6
Nas-gly-pam-phe-P
Nas-gly-phe-4-Am-pip
117091-16-4
CHEMBL23430
N(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide
N-alpha-(2-Naphthylsulfonyl-gly)-4-amindino-phe piperidide hydroiodide
N-(3-(4-Carbamimidoylphenyl)-1-oxo-1-(piperidin-1-yl)propan-2-yl)-2-(naphthalene-2-sulfonamido)acetamide
N-[3-(4-carbamimidoylphenyl)-1-oxo-1-piperidin-1-ylpropan-2-yl]-2-(naphthalen-2-ylsulfonylamino)acetamide
Acetamide, N-(1-((4-(aminoiminomethyl)phenyl)methyl)-2-oxo-2-(1-piperidinyl)ethyl)-2-((2-naphthalenylsulfonyl)amino)-, (S)-
A-NAPAP
N-alpha-(2-Naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide
N?-(2-Naphthalenesulfonylglycyl)-4-amidino-D,L-phenylalaninepiperidide
Nalpha-(2-Naphthalenesulfonylglycyl)-4-amidino-D,L-phenylalaninepiperidide
rac-1-[(R*)-N-[N-(2-Naphtylsulfonyl)glycyl]-2-[4-(aminoiminomethyl)benzyl]glycyl]piperidine
N-[3-(4-carbamimidoylphenyl)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-2-(naphthalene-2-sulfonamido)acetamide
ZN2007 Na
SCHEMBL8144360
DTXSID701006618
BCP20841
BDBM50457934
Na-(2-Naphthalenesulfonylglycyl)-4-amidino-DL-phenylalanine piperidide
(+/-)-N-[1-[[4-(Aminoiminomethyl)phenyl]methyl]-2-oxo-2-(1-piperidinyl)ethyl]-2-[(2-naphthalenylsulfonyl)amino]acetamide
PD119746
N alpha -(2-Naphthalenesulfonylglycyl)-4-amidino-D,L-phenylalaninepiperidide
N-[3-(4-Carbamimidoylphenyl)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-2-[(naphthalene-2-sulfonyl)amino]ethanimidato