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Cytarabine Lipid Conjugate

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Identification
Molecular formula
C33H49N3O6
CAS number
93585-38-7
IUPAC name
N-[1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]docosanamide
State
State

This compound is typically a solid at room temperature. It is generally stable under normal temperatures and pressures.

Melting point (Celsius)
72.00
Melting point (Kelvin)
345.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
661.75g/mol
Molar mass
661.9530g/mol
Density
1.1400g/cm3
Appearence

The compound generally appears as a white or off-white solid. Its form is usually crystalline powder, which may have a slight sheen or gloss.

Comment on solubility

Solubility of N-[1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]docosanamide

The solubility of N-[1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]docosanamide (C33H49N3O6) is a key aspect of its behavior in various environments. Understanding its solubility properties can help predict how it behaves in biological systems and different solvents. Here are some insights into the compound's solubility characteristics:

  • Polar and Nonpolar Nature: Due to the presence of multiple functional groups including hydroxyl (-OH) and amide (-CONH2), the compound exhibits a combination of polarity. This dual nature suggests variable solubility in:
    • Polar Solvents: More likely to be soluble in water and alcohols due to the hydroxyl groups.
    • Nonpolar Solvents: Solubility in nonpolar solvents may be limited due to the hydrophilic nature of the functional groups.
  • Temperature Dependence: Solubility may also change with temperature. Generally, an increase in temperature can enhance the solubility of solids in liquids.
  • Concentration Effects: At lower concentrations, the compound might exhibit increased solubility; however, precipitation may occur at higher concentrations depending on saturation limits.

Overall, the solubility of this compound reflects a complex interplay of its molecular structure and the properties of the solvent. As with many chemical compounds, it is crucial to conduct experimental solubility tests to obtain precise data for practical applications.

Interesting facts

Exploring N-[1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]docosanamide

N-[1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]docosanamide is a compound of remarkable complexity and diversity, presenting a unique blend of functional groups that offer intriguing possibilities for scientific exploration. Below are some interesting facets of this compound:

  • Complex Structure: The molecule showcases a pyrimidine ring linked to a tetrahydrofuran unit. This combination is relatively rare and could allow for innovative interactions in biological systems.
  • Potential Biological Activity: The presence of hydroxyl groups on the sugar moiety hints at potential biodistribution and bioactivity, which could be valuable in pharmaceutical applications or molecular biology.
  • Surface Activity: Given its amphiphilic nature due to the long docosanamide chain, this compound might exhibit properties suitable for use in drug delivery systems, aiding in the solubilization of hydrophobic drugs.
  • Mode of Action: This compound may function through the modulation of metabolic pathways, drawing interest as a potential therapeutic agent for various conditions that involve the pyrimidine structure.

Furthermore, researchers can explore the implications of its high carbon content and the influence of its complex structure on both chemical reactivity and biological interactions. Each functional group provides a site for potential modification, allowing chemists to tailor the compound for specific applications. In essence, N-[1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]docosanamide stands as a testament to the creativity of organic synthesis, opening doors to further research in medicinal chemistry and materials science.

Synonyms
BEHENOYL-ARABINOFURANOSYL-CYTOSINE
N-[1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]docosanamide
BHAC
4-(docosanoylamino)-1-pentofuranosylpyrimidin-2(1h)-one
BH-AC
SCHEMBL7963
CHEMBL1965199
DTXSID00860686
DOCOSANAMIDE,NUCLEOSIDE DERIV
NSC239336
AKOS015895202
SB67389
NCGC00167964-01
NCI60_001919
N4-BEHENOYL-1-B-D-ARABINOSYLCYTOSINE
NS00125216
Docosanamide,2-dihydro-2-oxo-4-pyrimidinyl)-